scholarly journals Renal cell carcinoma seeding of a percutaneous biopsy tract

2013 ◽  
Vol 7 (3-4) ◽  
pp. E176-179 ◽  
Author(s):  
Jeffrey K. Mullins ◽  
Ronald Rodriguez
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Cyst ◽  
Percutaneous Biopsy ◽  
Papillary Renal Cell Carcinoma ◽  
Intravenous Contrast ◽  
Fuhrman Grade ◽  
To Receive ◽  
Tumour Seeding

We report the case of a 68-year-old male with extension of papillary renal cell carcinoma (Fuhrman grade III) along a percutanous biopsy tract detected at the time of partial nephrectomy. Biopsy was performed to a obtain tissue diagnosis of a complex renal cyst as the patient was unable to receive intravenous contrast for imaging due to a severe allergy. Although biopsy of indeterminate renal lesions can provide valuable diagnostic information, there are inherent risks associated with this procedure. The rare occurrence of tumour seeding should be considered when recommending percutaneous biopsy to a patient with a renal mass.

scholarly journals Papillary Renal Cell Carcinoma Seeding along a Percutaneous Biopsy Tract

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Deanne Soares ◽  
Nariman Ahmadi ◽  
Oana Crainic ◽  
John Boulas
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Rare Complication ◽  
Percutaneous Biopsy ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Masses ◽  
Renal Lesions ◽  
Tumour Seeding ◽  
Pathological Assessment

We report a case of tumour seeding caused by percutaneous biopsy of a papillary renal cell carcinoma detected on pathological assessment of the partial nephrectomy specimen in a 50-year-old male. Whilst percutaneous biopsy of renal masses is considered to be safe and can be a valuable tool in the assessment of certain renal lesions, it is not without risks. This rare complication should be taken into consideration before contemplating its use in a patient.

scholarly journals Clear Cell Papillary Renal Cell Carcinoma: A Potential Mimic of Conventional Clear Cell Renal Carcinoma on Core Biopsy

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Heath Liddell ◽  
Anton Mare ◽  
Sean Heywood ◽  
Genevieve Bennett ◽  
Hin Fan Chan
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Core Biopsy ◽  
Clear Cell ◽  
Incidental Finding ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Cell Carcinomas ◽  
Fuhrman Grade ◽  
Stage Renal Disease

Clear cell papillary renal cell carcinoma (CCP-RCC) is a recently described, relatively uncommon variant of renal cell carcinoma (RCC) with a reported incidence of 4.1%. Thought to only arise in those with end stage renal disease, CCP-RCC is increasingly identified in those without renal impairment. CCP-RCCs have unique morphologic, genetic, and immunohistochemical features distinguishing them from both conventional clear cell renal cell carcinomas and papillary renal cell carcinomas. Immunohistochemically, these tumors are positive for CK7 and negative for CD10 and racemase. This is in contrast to conventional cell renal cell carcinomas (CK7 negative, CD10 positive) and papillary cell carcinomas (CK7, CD10, and racemase positive). These tumours appear to be indolent in nature, with no current documented cases of metastatic spread. We present the case of a 42-year-old female who presented with an incidental finding of a renal mass that on a core biopsy was reported as clear cell carcinoma, Fuhrman grade 1. She subsequently underwent a radical nephrectomy and further histological examination revealed the tumor to be a clear cell papillary renal cell carcinoma, Fuhrman grade 1.

Re: Fuhrman Grade Provides Higher Prognostic Accuracy Than Nucleolar Grade for Papillary Renal Cell Carcinoma

2011 ◽  
Vol 185 (1) ◽  
pp. 356-358 ◽  
Author(s):  
Brett Delahunt ◽  
Peter B. Bethwaite ◽  
Rose J. Miller ◽  
Dianne Sika-Paotonu ◽  
John R. Srigley
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Fuhrman Grade ◽  
Prognostic Accuracy

scholarly journals Approach to Complex Renal Cysts: A Single Center Experience

2021 ◽  
Author(s):  
Nadir Kalfazade ◽  
Ekrem Güner
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Cyst ◽  
Renal Cysts ◽  
Papillary Renal Cell Carcinoma ◽  
Lesion Size ◽  
Cell Renal Cell Carcinoma ◽  
Study Results ◽  
The Mean

Objective: Our objective in this study was to present the data for patients followed-up and underwent surgery due to complex renal cyst using Bosniak classification system. Method: Data of all patients followed-up or underwent surgery via open / minimal invasive methods due to complex renal cyst in our clinic between 2016 and 2019 were retrospectively evaluated. Bosniak category IIF and higher lesions were included in the study. Results: A total of 83 patients were included in the study. The mean age of the patients was 52 ±10.1 years and 40 (48.2%) were male and 43 (51.8%) were female. 53 (63.9%) patients had Bosniak IIF, 18 (21.7%) patients had Bosniak III and 12 (14.5%) patients had Bosniak IV lesions. Mean lesion size was 54±27.4 mm. Surgery was performed in a total of 41 (49.4%) patients. Based on final pathology result, while benign pathologies were detected in 13 (31.7%) patients, clear cell renal cell carcinoma was detected in 22 (53.7%) patients and papillary renal cell carcinoma in 6 (14.6%) patients. Malignity rates were detected as 18.9%, 44.4% and 83.3% in Bosniak IIF, III and IV lesions respectively. While the mean lesion size of patients who had benign pathology were 64.6±18.4 mm, mean lesion size of patients with malign pathology were 58.3±29.7 mm (p =.41). Conclusion: Progression is an important malignity finding in Bosniak IIF lesions. An important amount of especially Bosniak III lesions is overtreated. Thus, active surveillance is a treatment which should be considered in these patients. More comprehensive prospective randomized studies are needed.

scholarly journals A Case Report of Papillary Renal Cell Carcinoma Seeding along a Percutaneous Biopsy Tract

2018 ◽  
Vol 08 (04) ◽  
pp. 139-146
Author(s):  
Christine Busset ◽  
Sandrine Vijgen ◽  
Benoît Lhermitte ◽  
Pu Yan
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Percutaneous Biopsy ◽  
Papillary Renal Cell Carcinoma

scholarly journals A Rare Finding of Clear Cell Papillary Renal Cell Carcinoma in a Complex Renal Cyst

2019 ◽  
Vol 4 (09) ◽  
Author(s):  
Dr Suneetha K. P. ◽  
Dr Dilip Javali ◽  
Dr Gayathri J.
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Renal Cyst ◽  
Histopathological Examination ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Cell Carcinoma Patient ◽  
Low Grade ◽  
Polar Regions

Multilocular cystic renal cell carcinomas (RCC’s), Unilocular cystic RCC’s and RCC’s with extensive cystic necrosis and unilocular cysts with mural tumor nodules forms a wide category of RCC’s. Cystic RCC’s represent upto 3-14% of all RCC’s.[1] Here we present a case of 68 year old female who is a known case of DM, hypothyroidism, bronchial asthma presenting with complains of pain abdomen since 1 year. She has been a case of renal TB and on ATT 30 years ago. Further the patient was evaluatedand foundto have a small partly exophytic cortical cyst measuring 13x12mm noted in the inter polar region posteriorly along with multiple well defined hyper dense non enhancing cortical and exohytic cysts notes in upper / lower and inter polar regions, largest measuring 1.8x1.7cms in upper pole suggestive of hemorrhagic cysts. A diagnosis of left renal complex cyst was made. Alaporoscopic left partial cystectectomy was done and sent for histopathological examination. Microscopy revealed Cystic clear cell fgv Renal cell carcinoma, Furhman Grade 1(Low grade) within a 0.1cm thickening which was further confirmed with IHC expressing strongly for CK7,PAX8 and CAIXand confirmed the diagnosis as Clear cell Papillary Renal cell carcinoma. Patient is being followed up and no recurrence / metastasis has been reported. This provides us an opportunity to consider an unusual finding of Clear Cell Papillary RCC in a complex renal cyst and to look into the cystic lesion with more importance helping us in avoiding missing a carcinoma as found in the present case.

Classification of oncocytic papillary renal cell carcinoma.

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 467-467
Author(s):  
Stephen Hembree Culp ◽  
Yunchuan Delores Mo ◽  
Mairo Diolombi ◽  
Helen P Cathro
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Cox Proportional Hazards ◽  
Fuhrman Grade ◽  
Female Ratio

467 Background: Over the past decade, genitourinary pathologists have increasingly recognized an oncocytic variant of papillary renal cell carcinoma (PRC) that can complicate classification as Type 1 or Type 2 PRC. The International Society of Urological Pathology recently proposed reclassifying oncocytic papillary renal cell carcinoma (OPRC) as a separate subtype. We set out to test the validity of separating oncocytic tumors from other PRC. Methods: 70 consecutive cases of PRC with sufficient tissue for analysis were reviewed from patients undergoing surgery at The University of Virginia (1992 to 2007). All cases were classified by type, including those with oncocytic features. Histologic, clinical, and outcomes data were analyzed based on type and the presence of oncocytic features. Results: A total of 15 (21.4%) tumors displayed oncocytic differentiation, the majority of which were Type 2 tumors (11 or 73.3%) (p < 0.001). The male to female ratio of OPRC cases was nearly 1:1 in contrast to a significant male bias historically seen in PRC. The presence of oncocytic features was significantly associated with higher Fuhrman grade (p < 0.001) and no OPRC tumors were multifocal as opposed to 13 (23.6%) of non-OPRC tumors. At a median follow-up of 79.9 months for the entire cohort, 5-yr disease specific survival (DSS) for OPRC patients was 79.0% which was intermediate between patients with Type 1 (93.4%) and Type 2 (44.4%) tumors. By Cox proportional hazards regression analysis, DSS of OPRC patients was significantly better than Type 2 patients (HR 0.12; 95% CI 0.03, 0.52, p = 0.004), but tended to be worse than Type 1 patients (HR 2.58; 95% CI 0.78, 8.50, p = 0.12). Conclusions: We report the largest cohort of OPRC patients to date. Patients with OPRC demonstrate a survival rate intermediate between that of patients with non-oncocytic Type 1 and Type 2 PRC. Though the majority of OPRC tumors were classified as Type 2 PRC, oncocytic features complicate histomorphologic typing. Therefore, classification of OPRC separately would clarify typing of PRC and improve the validity of Fuhrman nuclear grading for PRC. Our results support separation of OPRC from Type 1 and Type 2 PRC, based on both histomorphologic typing and patient survival.

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