scholarly journals Predictors of improvement in semen parameters after varicocelectomy for male subfertility: A prospective study

2015 ◽  
Vol 9 (9-10) ◽  
pp. 579 ◽  
Author(s):  
Waleed Shabana ◽  
Mohamed Teleb ◽  
Tamer Dawod ◽  
Ehab Elsayed ◽  
Esam Desoky ◽  
...  
Keyword(s):  
Prospective Study ◽  
Clinical Laboratory ◽  
The Other ◽  
Semen Parameters ◽  
Successful Outcome ◽  
Total Testosterone ◽  
Progressive Motility ◽  
Sperm Density ◽  
Logistic Analysis ◽  
Grade Ii

Introduction: We aim to predict results of varicocelectomy on sperm density and progressive motility using preoperative clinical, laboratory and radiological data and to propose cut-off values for significant parameters.Methods: This prospective study was carried out between July 2011 and June 2014. We included 123 patients in our study. They were diagnosed with primary infertility with varicocele, were scheduled for varicocelectomy, and completed their follow-up. We excluded patients with azoospermia, total necrospermia, recurrent varicocele, and pituitary hormonal abnormalities. Varicocele was diagnosed and graded by physical examination and colour Doppler ultrasound. Semen analyses were completed preoperatively and 6 months postoperatively. Microscopic subinguinal varicocelectomy was done in all cases. Patient demographics, pre- and postoperative clinical data (varicocele grade and semen parameters) were statistically analyzed.Results: The mean ± standard deviation of age, body mass index, and subfertility duration was 28.3 ± 7.4 years, 29.1 ± 2.7 kg/m2, and 21.9 ± 7.1 months, respectively. About 53% of our patients (n = 66) had bilateral varicocele, and unilateral disease was found in the other 57 (46.3%) cases. Varicocele grade I was diagnosed in 42 (34.1%) patients, while the other 81 (65.9%) patients had grade II or III. Higher grades of varicocele, preoperative total testosterone level, sperm density, and progressive motility had a statistically significant impact on the outcome of varicocelectomy in univariate testing. Multivariate logistic analysis revealed that grade of preoperative varicocele (95% confidence interval [CI] 5.6–6.3, p = 0.007) and sperm density (95% CI 2.7–1.6, p = 0.0035), and progressive motility (95% CI 1.1–2.3, p = 0.0123) are independent predictors of semen parameters improvement after varicocelectomy.Conclusion: The grade of the varicocele, sperm density, and progressive motility are major predictors of outcome in varicocelectomy. Cut-off values of >8 million/mL and >18% for sperm density and progressive motility, respectively, in men with varicocele grade II or III, indicate a successful outcome.

scholarly journals The relationship between serum hormone levels (follicle-stimulating hormone, luteinizing hormone, total testosterone) and semen parameters

2015 ◽  
Vol 87 (3) ◽  
pp. 194 ◽  
Author(s):  
Mehmet Zeynel Keskin ◽  
Salih Budak ◽  
Tuǧba Zeyrek ◽  
Orçun Çelik ◽  
Oguz Mertoglu ◽  
...  
Keyword(s):  
Sperm Concentration ◽  
Reference Value ◽  
Semen Parameters ◽  
Total Testosterone ◽  
Testosterone Levels ◽  
Progressive Motility ◽  
Semen Volume ◽  
Significant Difference ◽  
Serum Hormone ◽  
Serum Gonadotropin

Objective: The aim of this study was to investigate the effect of serum gonadotropin and total testosterone levels on semen parameters. Materials and Methods: Three hundred and eighty-two patients that applied to a male infertility polyclinic were included in our study. Serum gonadotropin and total testosterone levels and semen parameters of the patients were analyzed during the first visit to the clinic. The reference FSH value was 1.5-12.4 mIU/mL, that of LH was 1.7-8.6 mIU/mL and the reference value for total testosterone was 249-836 ng/dL. Results: While there was no statistically significant difference between the patients with low gonadotropin levels and the controls regarding any of the semen parameters (p > 0.05), there was a strong statistically significant difference between the patients with high gonadotropin levels and the controls regarding sperm concentration (p = 0.000), total motility (p = 0.000), progressive motility (p = 0.000), and morphology (p = 0.000). There was a strong statistically significant difference between the patients with low testosterone levels and the controls regarding total motility (p = 0.012) and progressive motility (p = 0.010), and a weak statistically significant difference in morphology (p = 0.042). There was no statistically significant difference in semen volume or sperm concentration (p > 0.05). There was no statistically significant difference in any of the semen parameters between the patients with high testosterone levels and the controls (p > 0.05). Conclusions: Our findings especially regarding LH and T levels are not in agreement with previous reports. In this regard, there is a need for larger-scale and randomized trials to resolve this discrepancy.

scholarly journals Comparison of three different media for freezing of epididymal sperm from the African buffalo (Syncerus caffer) and influence of equilibration time on the post-thaw sperm quality

2004 ◽  
Vol 71 (3) ◽  
Author(s):  
F.C. Herold ◽  
K. De Haas ◽  
D. Cooper ◽  
B. Colenbrander ◽  
J.O. Nothling ◽  
...  
Keyword(s):  
South Africa ◽  
Sperm Quality ◽  
The Other ◽  
Semen Parameters ◽  
Equilibration Time ◽  
African Buffalo ◽  
Epididymal Sperm ◽  
Progressive Motility ◽  
Reproductive Techniques ◽  
Buffalo Semen

Assisted reproductive techniques might prove themselves useful tools in producing buffaloes free of specific diseases (BFSD), which are in demand in South Africa. Freezing protocols for African buffalo semen must not only result in good post-thaw qualities, but must also be practical. Epididymal sperm from six mature African buffalo bulls was collected, diluted with three different semen extenders and frozen. Pre-freezing equilibration times between 2 and 9 h were tested. Total and progressive motility, longevity and acrosomal integrity were measured and compared. The use of TriladylTM proved to result in better post-thaw parameters than the other two diluents. Equilibration times of between 4 and 9 h did not influence post-thaw sperm qualities significantly. For some of the treatments, exposure to semen extenders before freezing for less than 4 h resulted in inferior post-thaw semen parameters.

Effect of Bioxcell® and Triladyl® Extenders and Removal of Seminal Plasma on Equilibrated and Cryopreserved Semen from South African Unimproved Indigenous Bucks

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Nethenzheni LP ◽  
◽  
Mphaphathi ML ◽  
Madzhie LR ◽  
Negota NC ◽  
...  
Keyword(s):  
Seminal Plasma ◽  
Membrane Integrity ◽  
The Other ◽  
Semen Parameters ◽  
Lower Percentage ◽  
Mean Values ◽  
Sperm Analysis ◽  
Progressive Motility ◽  
Frozen Semen ◽  
Motility Rate

The objectives of the study were to evaluate the effect of two extenders (Triladyl® and Bioxcell®) and the removal of seminal plasma on indigenous buck’s semen. Semen was collected from six indigenous bucks using an electro-ejaculator. Raw semen was pooled and randomly allocated into six groups as follows: (i) Raw non-washed, (ii) Raw washed, (iii) Triladyl®-washed, (iv) Triladyl®-non-washed, (v) Bioxcell®-washed and (vi) Bioxcell®-non-washed. Both the Triladyl® and Bioxcell® washed semen samples groups were diluted (1:4 v/v) with Phosphate Buffered Saline (PBS) then centrifuged at 1500x g for ten min and seminal plasma was removed. The groups were analysed for spermatozoa motility rates using Computer-Aided Sperm Analysis (CASA). The spermatozoa viability was assessed using Eosin-Nigrosin, acrosome integrity using Spermac, chromatin structure using Acridine Orange, and mitochondria using JC-1 staining solutions. Semen samples were diluted (1:4 v/v) as follows: Triladyl® (washed and non-washed) or Bioxcell® (washed and non-washed) and then equilibrated at 5°C for 2 hours. Equilibrated semen samples in 0.25 mL French straws were placed 5 cm above a Liquid Nitrogen (LN2) vapour for 10 min, and stored for one month. Frozen semen straws per treatment group were thawed at 37°C for 30 seconds. Significant differences among the mean values of semen parameters were determined by Tukey’s test using ANOVA, GLM procedure of SAS version 12.1 of 2010. The spermatozoa progressive motility rate in non-washed semen extended with Bioxcell® was significantly higher (89.6±7.5a) compared with that of non-washed Triladyl®, washed Bioxcell® and Triladyl® (P<0.05). Live spermatozoa percentage in washed semen extended with Triladyl® extender was reduced (27.7±17.1) significantly compared with the other groups (P<0.05). There was a lower percentage of spermatozoa with high mitochondrial membrane potential in non-washed and washed semen extended with Bioxcell® (39.5±23.2 and 37.9±28.6, respectively) compared with that of non-washed and washed semen extended with Triladyl® (P>0.05). The spermatozoa progressive motility rate in non-washed semen extended with Bioxcell® (58.5±10.0) extender was significantly higher compared with that of the other groups (P<0.05). There was a higher live and normal spermatozoa percentage in non-washed semen extended with Bioxcell® (45.7±21.2) compared with that of the other groups (P<0.05). In conclusion, Washing of seminal plasma in semen extended with Triladyl® was not essential, as it lowered viability, progressive motility and chromatin membrane integrity prior and post-cryopreservation. However, Bioxcell® extender was found to be more suitable for preserving spermatozoa during equilibration and freezing/thawing process of non-washed and washed buck semen.

Agni - Key factor for Shodhananga Snehapana.

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Pavithra. S. ◽  
H. G. Gouda ◽  
Rajalakshmi M. G.
Keyword(s):  
Operative Procedure ◽  
The Other ◽  
Successful Outcome ◽  
Other Hand ◽  
Key Factor ◽  
Health And Disease

Agni is termed as Vaishwanara as it takes the person from Mruthyuloka to Swargaloka. It is an important factor and is equitant to Prana; is one among Dashaprana Ayatana. Agni in Shareera is present in different forms with different actions. It is the responsible factor for both health and disease; on the other hand the successful outcome of treatment is also dependant on Agni. Chikitsa (treatment) is the process of bestowing normalcy which is either brought by Shodhana (purificatory) or Shamana (palliative) Karma. Snehapana is a pre-operative procedure for Shodhana Chikitsa where in Sneha Dravya (medicated fat) is administered for attainment of Upasthita Dosha Avastha and further ease in elimination of the vitiated Doshas. Assessment of Dosha, Dushya, Vyadhi Avastha, Roga Bala, Rogi Bala, Agni, Koshta etc. factors are essential for the attainment of Chikitsa Phala. Assessment of Agni not only helps in understanding Vyadhi but also enables to plan the dosage of Sneha to be administered. Thus this paper is an attempt to throw light on the importance of Agni, assessment of Agni and Agni Bala prior to Shodhananga Snehapana.

Lifespan of peripheral intravenous short catheters in hospitalized children: A prospective study

2021 ◽  
pp. 112972982110052
Author(s):  
Maria Elizabeth Gómez-Neva ◽  
Martin Alonso Rondon Sepulveda ◽  
Adriana Buitrago-Lopez
Keyword(s):  
Cohort Study ◽  
Prospective Study ◽  
The Other ◽  
Hospitalized Children ◽  
Intravenous Catheter ◽  
Survival Analyses ◽  
Median Lifespan ◽  
Pediatric Services ◽  
A Prospective Study ◽  
Intravenous Catheters

Objective: To estimate the recommended lifespan of 223 peripheral intravenous accesses in pediatric services. Method: In this cohort study, we monitored the time of intravenous catheter between insertion and removal in children aged up to 15 years old in a Hospital from Bogotá-Colombia. The routine catheter observations was registered in questionnaires during nursing shifts. Survival analyses were performed to analyze the lifespan of the catheter free of complications. Results: The median lifespan of peripheral intravenous catheters without complications was 129 h (IQR 73.6–393.4 h). This median time free from complications was much lower for children ⩽1 year 98.3 h (IQR 63–141 h), than for participants aged >1 year 207.4 h (IQR 100–393 h). Catheters of 24 G (gauge) caliber had a median complication free time of 128 h (IQR 69–207 h) and 22 G calibers 144 h (IQR 103–393 h). Conclusions: In this study, 75% of peripheral indwell catheters remained free from complications for 74 h, the other extreme 25% of these patients could remain up to 393 h.

scholarly journals Parenchymal Guidewire Perforation during ERCP: An Unappreciated Injury

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
M. Ezzedien Rabie ◽  
Saad Al Faris ◽  
Ali Nasser ◽  
Abdul Aziz Shahir ◽  
Yasser Al Mahdi ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Emergency Surgery ◽  
Clinical Course ◽  
The Other ◽  
Clinical Deterioration ◽  
Medical Community ◽  
Successful Outcome ◽  
Hepatic Parenchyma ◽  
Pancreatic Parenchyma ◽  
Intraperitoneal Drainage

ERCP is attended with certain complications, the majority of which are well known to the medical community. Other less-known complications also exist. Guidewire injury to the hepatic or pancreatic parenchyma represents one of the much less appreciated, albeit preventable, complications. In this report, we present the clinical course of three patients who sustained guidewire perforation of the pancreatic or hepatic parenchyma. In one patient, the clinical deterioration was confidently attributed to guidewire perforation of the pancreatic parenchyma. Conservative treatment was successful and unnecessary emergency surgery was thus avoided. In the other two, in whom the cause of the clinical deterioration was unclear, an emergency surgery was performed. Guidewire injury to the hepatic parenchyma was then confirmed which needed only intraperitoneal drainage, with successful outcome.

THE AGE OF ATTAINING BLADDER CONTROL

PEDIATRICS ◽  
1968 ◽  
Vol 42 (4) ◽  
pp. 614-626
Author(s):  
Wallace C. Oppel ◽  
Paul A. Harper ◽  
Rowland V. Rider
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Prospective Study ◽  
Life Table ◽  
Median Duration ◽  
The Other ◽  
Large Contribution ◽  
Median Length ◽  
Bladder Control ◽  
Study Population

Data in life table form are presented from a 12-year prospective study of 859 children on the age of attaining bladder control for waking and sleeping hours by three indices: (1) age of initial dryness, (2) age of final dryness, and (3) the prevalence of dryness. By use of these indices the large contribution of relapsers to enuresis is seen. The prevalence of bedwetting in the study population was greater than that reported in other studies; the validity of this finding is defended. A larger proportion of female than male children attained both day and night dryness during the first 2 years of life. The percentage of Negro boys who first attained dryness was less than that of the other three race-sex groups after 2 years of age and was significantly less than that of Negro girls until 9 years of age. One quarter of the 817 children who attained initial nighttime dryness by age 12 relapsed; these relapsing episodes had a median duration of 2.5 years. One tenth of 855 children who attained initial daytime dryness had relapses, and the median length of these was 1.2 years. Relapsing occurred much more frequently in Negro than Caucasian children; it also was seen more often in Caucasian males than in Caucasian females. Low birth weight children had a higher percentage of children wet for both waking and sleeping hours than did full birth weight children.

scholarly journals Bridge-therapy with enoxaparin in the preoperative period of endarterectomy

2010 ◽  
Vol 68 (5) ◽  
pp. 775-777
Author(s):  
Jair Leopoldo Raso ◽  
Rogério Zenóbio Darwich ◽  
Francisco de Lucca Jr ◽  
Romeu Valle Santana ◽  
Marco Túlio Tanure ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Mortality Rate ◽  
Prospective Study ◽  
Low Molecular Weight Heparin ◽  
The Other ◽  
Low Molecular Weight ◽  
Preoperative Period ◽  
Safe Strategy ◽  
A Prospective Study ◽  
Bridge Therapy

Cervical clot is one of the complications of endarterectomy. This risk may be higher in patients using aspirin or clopidogrel. On the other hand, stroke may occur if the medication is interrupted before surgery. We carried out a prospective study of 124 endarterectomies in 119 patients in which aspirin or clopidogrel was stopped and a bridge-therapy with enoxaparin was administered preoperatively. There was no case of stroke during the period of the bridge-therapy. One patient developed cervical clot (0.8%) in the fifth postoperative day. Mortality rate in this series was 0.8%. There was no complication directly related to the use of enoxaparin. Bridge-therapy with low molecular weight heparin is a safe strategy for patients elected for endarterectomy

scholarly journals Dosages of androgenic hormones in adolescent patients with severe acne

2020 ◽  
Vol 66 (1) ◽  
pp. 36-41
Author(s):  
Marisa Gonzaga da Cunha ◽  
Caio Moraes ◽  
Giovana Cebrian ◽  
Rafaela Ferreira da Silva ◽  
Sônia Isabel Friedlaender Reple ◽  
...  
Keyword(s):  
Acne Vulgaris ◽  
Adult Life ◽  
Dehydroepiandrosterone Sulfate ◽  
Female Adolescents ◽  
Total Testosterone ◽  
Hormonal Changes ◽  
Cross Sectional ◽  
Severe Acne ◽  
Grade Ii ◽  
Antiandrogen Therapy

SUMMARY OBJECTIVE Acne vulgaris in female adolescents, when severe or accompanied by other signs of androgenization, may represent a sign of hyperandrogenemia often underdiagnosed, which will have harmful consequences for adult life. The objective of this cross-sectional and retrospective study was to demonstrate the incidence of hormonal changes in the cases of female adolescents with severe or extensive acne, with or without other signs of hyperandrogenism, and propose a hormonal research pattern which should be indicated in order to detect early hyperandrogenemia. METHODS The medical records of 38 female patients aged between 9 and 15 years old with grade II and/or III acne were analyzed. The dehydroepiandrosterone sulfate, dehydroepiandrostenedione, and androstenedione, total testosterone, and dihydrotestosterone sulfate hormones were required prior to initiation of treatment. The hormonal dosages were performed in the serum after at least 3 hours of fasting by means of radioimmunoassay tests. RESULTS Of the 38 patients included, 44.7% presented changes in androgen levels (hyperandrogenemia), and the two most frequently altered hormones were DHEA and androstenedione, with the same incidence (23.6%). CONCLUSIONS The correct and early diagnosis provides an effective and agile approach, including antiandrogen therapy, with the purpose of avoiding the reproductive and metabolic repercussions, besides controlling the inflammatory picture and avoid aesthetic complications.

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