scholarly journals Exercise effects on adipokines and the IGF axis in men with prostate cancer treated with androgen deprivation: A randomized study

2013 ◽  
Vol 7 (11-12) ◽  
pp. 692 ◽  
Author(s):  
Daniel Santa Mina ◽  
Michael K. Connor ◽  
Shabbir M.H. Alibhai ◽  
Paul Toren ◽  
Crissa Guglietti ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Composition ◽  
Growth Factor ◽  
Resistance Training ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Insulin Like Growth Factor ◽  
Home Based ◽  
Igfbp 3

Background: Androgen deprivation therapy (ADT) has significant deleterious effects on body composition that may be accompanied by unfavourable changes in adipokine levels. While exercise has been shown to improve a number of side effects associated with ADT for prostate cancer, no studies have assessed the effect of exercise on adiponectin and leptin levels, which have been shown to alter the mitogenic environment.Methods: Twenty-six men with prostate cancer treated with ADT were randomized to home-based aerobic exercise training or resistance exercise training for 24 weeks. Adiponectin, leptin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3) were analyzed by ELISA (enzyme-linked immunosorbent assay), in addition to physical activity volume, peak aerobic capacity, and anthropometric measurements, at baseline, 3 months and 6 months.Results: Resistance exercise significantly reduced IGF-1 after 3 months (p = 0.019); however, this change was not maintained at 6 months. At 6 months, IGFBP-3 was significantly increased compared to baseline for the resistance training group (p = 0.044). In an exploratory analysis of all exercisers, favourable changes in body composition and aerobic fitness were correlated with favourable levels of leptin, and favourable leptin:adiponectin and IGF-1:IGFBP-3 ratios at 3 and 6 months.Conclusions: Home-based exercise is correlated with positive changes in adipokine levels and the IGF-axis that may be related to healthy changes in physical fitness and body composition. While the improvements of adipokine markers appear to be more apparent with resistance training compared to aerobic exercise, these findings must be considered cautiously and require replication from larger randomized controlled trials to clarify the role of exercise on adipokines and IGF-axis proteins for men with prostate cancer.

scholarly journals Changes levels of myokines after aerobic training and resistance training in post-menopausal females with obesity

2020 ◽  
Author(s):  
Sunghwun Kang ◽  
Il Bong Park ◽  
Seung-Taek Lim
Keyword(s):  
Body Composition ◽  
Resistance Training ◽  
Exercise Training ◽  
Physical Fitness ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Exercise Group ◽  
Muscle Endurance ◽  
Post Menopausal

Abstract Background To investigate changes in levels of myokines after regular aerobic training and resistance training in post- menopausal females with obesity. Methods Among 41 post- menopausal obese females volunteered to participate in this study performed regular physical exercise training (aerobic exercise and resistance exercise). These participants were randomly assigned to one aerobic exercise group (n = 21) and one resistance exercise group (n = 20). The experimental group performed three days of aerobic exercise and resistance exercise per week (i.e., Monday, Wednesday, and Friday) each group. Body composition, physical fitness, and myokines were measured at baseline, 6 weeks, and 12 weeks. Results Two-way within-factor ANOVA revealed group × time interaction for body mass index (BMI, p < 0.05). In the resistance exercise group, muscle endurance, power, and agility were significantly increased at 12 weeks than those at 6 weeks and baseline. In the aerobic exercise group, muscle strength, flexibility, muscle endurance, and agility were greater at 12 weeks than those at 6 weeks and baseline. Levels of IL-6, IL15, and BDNF were greater at 12 weeks than those at 6 weeks and baseline in both exercise groups. Conclusions Aerobic exercise training and resistance exercise training can change levels of myokines and improve body composition and physical fitness of obese females. These findings provide preliminary evidence that obese females need to exercise or perform physical activity to improve their levels of myokines and physical fitness.

Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4

1993 ◽  
Vol 136 (1) ◽  
pp. 91-104 ◽  
Author(s):  
L. R. Donahue ◽  
W. G. Beamer
Keyword(s):  
Body Composition ◽  
Growth Factor ◽  
Gh Deficiency ◽  
Body Water ◽  
Insulin Like Growth Factor ◽  
Gh Therapy ◽  
Factor I ◽  
Igf I ◽  
Body Compartments ◽  
Igfbp 3

ABSTRACT Although GH is known to regulate somatic growth during development, its role in regulating adult body composition is less well defined. The effects of GH on individual body compartments – water, fat, protein and mineral – are achieved both by the action of GH and by a GH-induced hormone, insulin-like growth factor-I (IGF-I). We used a genetic model of GH deficiency, the 'little' (gene symbol lit) mouse, to determine the GH regulation of IGF-I and its insulin-like growth factor-binding proteins (IGFBPs) and to define the interaction between these hormones and each body compartment in adults. Our results showed that GH-deficient lit/lit mice had reduced levels of serum IGF-I (range 38–130 μg/l) compared with normal lit/+ littermates (range 432–567 μg/l) between 2 and 52 weeks of age. The lit/lit mice did not experience the fivefold increase in IGF-I between 2 and 4 weeks of age that was seen in lit/+ mice. In lit/lit serum, overall binding of 125I-labelled IGF-I to the four IGFBPs was reduced, solely in response to a reduced amount of IGFBP-3. No overall differences were found between lit/lit and lit/+ mice in the binding of 125I-labelled IGF-I to IGFBP-2, -1 or -4. Age-related declines in IGF-I and IGFBPs were seen in lit/lit mice. However, adult levels of IGF-I were maintained in lit/+ mice to at least 52 weeks of age, as were levels of IGFBP-1 and -4, while IGFBP-3 and -2 declined with age. With respect to body composition, comparison of lit/lit with lit/+ mice showed that the lit/lit mice were characterized by abnormally large adipose tissue stores and reduced body water, protein and mineral from 2 weeks onward. These changes occurred despite normal energy intake in lit/lit mice up to 52 weeks of age, indicating that neither undernutrition nor hyperphagia is characteristic of this GH-induced model of obesity. Furthermore, lit/lit males accrued more body fat beginning at an earlier age than lit/lit females. With advancing age, the per cent body fat increased in both lit/lit and lit/+ mice, while the per cent body water and mineral declined. In lit/lit but not lit/+ mice, per cent protein also declined with age. The changes in body water and fat are attributable to lack of adequate GH in the genetically GH-deficient lit/lit mouse. On the other hand, the changes in body protein are more likely to be effects of IGF-I. Changes in mineral observed in lit/lit mice could be the result of action by GH, IGF-I or both hormones. Therefore, when GH is chronically manipulated by GH deficiency as in lit/lit mice, by GH excess as in acromegaly, or by GH therapy, all four body compartments are affected, suggesting that GH therapy is most valuable when the treatment goal is to alter overall body composition. Journal of Endocrinology (1993) 136, 91–104

A Randomized Trial of Aerobic versus Resistance Exercise in Prostate Cancer Survivors

2013 ◽  
Vol 21 (4) ◽  
pp. 455-478 ◽  
Author(s):  
Daniel Santa Mina ◽  
Shabbir M.H. Alibhai ◽  
Andrew G. Matthew ◽  
Crissa L. Guglietti ◽  
Meysam Pirbaglou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Side Effects ◽  
Resistance Training ◽  
Physical Fitness ◽  
Resistance Exercise ◽  
Cancer Survivors ◽  
Training Group ◽  
Well Being ◽  
Time Points ◽  
Home Based

Androgen-deprivation therapy (ADT) for prostate cancer (PCa) has side effects that significantly impair health-related quality of life (HRQOL). Exercise ameliorates many side effects of ADT, but different modalities, particularly in the home-based setting, have not been well studied. In this study the authors randomly assigned 66 PCa survivors receiving ADT to 6 mo of home-based aerobic or resistance training. Psychosocial well-being and physical fitness were measured at baseline, 3 and 6 mo, and then 6 mo postintervention. Intention-to-treat analyses showed that fatigue and HRQOL were not significantly different between groups; however, in a per-protocol analysis the resistance-exercise training group demonstrated clinically significant improvements in HRQOL. Differential within-group effects on physical fitness were also observed at various time points. At all time points, the aerobic-training group engaged in significantly more physical activity than the resistance-training group, a finding that should be further examined given evidence-based guidelines for activity volume in cancer survivors.

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