scholarly journals Metabolic features of clear-cell renal cell carcinoma: mechanisms and clinical implications

2011 ◽  
Vol 5 (4) ◽  
pp. 274-282 ◽  
Author(s):  
Jehonathan H. Pinthus ◽  
Kaitlyn F. Whelan ◽  
Daniel Gallino ◽  
Jian-Ping Lu ◽  
Nathan Rothschild
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Clinical Implications ◽  
Cell Renal Cell Carcinoma

JAK3 in clear cell renal cell carcinoma: Mutational screening and clinical implications

2013 ◽  
Vol 31 (6) ◽  
pp. 930-937 ◽  
Author(s):  
Michela de Martino ◽  
Maddalena Gigante ◽  
Luigi Cormio ◽  
Clelia Prattichizzo ◽  
Elisabetta Cavalcanti ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Clinical Implications ◽  
Cell Renal Cell Carcinoma ◽  
Mutational Screening

scholarly journals Metabolic features of clear-cell renal cell carcinoma: mechanisms and clinical implications

2013 ◽  
Vol 5 (4) ◽  
pp. 274
Author(s):  
Jehonathan H. Pinthus H. Pinthus ◽  
Kaitlyn F. Whelan ◽  
Daniel Gallino ◽  
Jian-Ping Lu ◽  
Nathan Rothschild
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Renal Cell ◽  
Clear Cell ◽  
Response To Therapy ◽  
Clinical Implications ◽  
Cell Renal Cell Carcinoma ◽  
Normal Cells ◽  
Dietary Nutrients

Central to the malignant behaviour that endows cancer cells withgrowth advantage is their unique metabolism. Cancer cells canprocess nutrient molecules differently from normal cells and useit to overcome stress imposed on them by various therapies. Thismetabolic conversion is controlled by specific genetic mutationsthat are associated with activation of oncogenes and loss of tumoursuppressor proteins. Understanding these processes is importantas it can lead to the discovery of biomarkers that can predict theaggressiveness of the disease and its response to therapy, and evenmore importantly, to the development of novel therapeutics. A classictumour in this respect is clear-cell renal cell carcinoma (RCC). Inthis review, we will begin with a brief summary of normal cellularbioenergetic pathways, which will be followed by a descriptionof the characteristic metabolism of glucose and lipids in clear-cellRCC cells and its clinical implications. Data relating to the potentialeffect of dietary nutrients on RCC will also be reviewed alongwith potential therapies targeted at interrupting specific metabolicpathways in clear-cell RCC.Le métabolisme unique des cellules cancéreuses est au coeur ducomportement malin qui leur confère un avantage sur le plan de lacroissance. Les cellules cancéreuses peuvent traiter les moléculesde nutriment différemment des cellules normales et utilisent cesmolécules pour surmonter le stress imposé par les différents traitements.La conversion métabolique est contrôlée par des mutationsgénétiques précises associées à l’activation d’oncogènes et à laperte de protéines de suppression tumorale. Il est important debien saisir ces processus, car leur élucidation peut mener à ladécouverte de biomarqueurs permettant de prédire l’agressivité dela maladie et la réponse au traitement et, fait encore plus important,elle peut mener à la mise au point de nouveaux médicaments. À cetégard, l’hypernéphrome à cellules claires représente une tumeurclassique. Dans cet article, nous commençons par résumer brièvementles voies bioénergétiques cellulaires normales, puis nouspoursuivons avec une description du métabolisme caractéristiquedu glucose et des lipides dans les cellules de l’hypernéphrome àcellules claires et ses répercussions cliniques. Les données associéesà l’effet potentiel des nutriments sur l’hypernéphrome à cellulesclaires seront aussi passées en revue, ainsi que les thérapiesciblées potentielles visant l’interruption de voies métaboliquesparticulières dans l’hypernéphrome à cellules claires.

scholarly journals Clinical Implications of HSC70 Expression in Clear Cell Renal Cell Carcinoma

2021 ◽  
Vol 18 (1) ◽  
pp. 239-244
Author(s):  
Yixiao Zhang ◽  
Xudong Zhu ◽  
Xinbo Qiao ◽  
Lisha Sun ◽  
Tianhui Xia ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Clinical Implications ◽  
Cell Renal Cell Carcinoma

Clinical Implications of Preoperative Serum Total Cholesterol in Patients With Clear Cell Renal Cell Carcinoma

Urology ◽  
2014 ◽  
Vol 83 (1) ◽  
pp. 154-158 ◽  
Author(s):  
Yoshio Ohno ◽  
Jun Nakashima ◽  
Yoshihiro Nakagami ◽  
Tatsuo Gondo ◽  
Makoto Ohori ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Total Cholesterol ◽  
Renal Cell ◽  
Clear Cell ◽  
Serum Total Cholesterol ◽  
Clinical Implications ◽  
Cell Renal Cell Carcinoma ◽  
Preoperative Serum

638: Macroscopic Tumor Necrosis is a Prognostic Indicator for Non-Metastatic Clear Cell Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 214-214
Author(s):  
Sung Kyu Hong ◽  
Byung Kyu Han ◽  
In Ho Chang ◽  
June Hyun Han ◽  
Ji Hyung Yu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Necrosis ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Cell Renal Cell Carcinoma ◽  
Macroscopic Tumor

Rare localization of renal cell carcinoma metastases in the paranasal sinuses and breast: a case report

2019 ◽  
Vol 22 (6) ◽  
pp. 13-22
Author(s):  
E. V. Kryaneva ◽  
N. A. Rubtsova ◽  
A. V. Levshakova ◽  
A. I. Khalimon ◽  
A. V. Leontyev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Paranasal Sinuses ◽  
Renal Cell ◽  
Clinical Case ◽  
Clear Cell ◽  
Malignant Tumors ◽  
Metastatic Potential ◽  
Cell Renal Cell Carcinoma ◽  
Metastatic Lesions

This article presents a clinical case demonsratinga high metastatic potential of clear cell renal cell carcinoma combined with atypical metastases to breast and paranasal sinuses. The prevalence of metastatic lesions to the breast and paranasal sinuses in various malignant tumors depending on their morphological forms is analyzed. The authors present an analysis of data published for the last 30 years. The optimal diagnostic algorithms to detect the progression of renal cell carcinoma and to evaluate the effectiveness of the treatment are considered.

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