scholarly journals Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455)

2011 ◽  
Vol 27 (3) ◽  
pp. 181-184 ◽  
Author(s):  
Tae-Sung Kim ◽  
Chang-Yeong Kim ◽  
Hae-Kyung Lee ◽  
Il-Hyun Kang ◽  
Mi-Gyeong Kim ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Transcriptional Activation ◽  
Estrogenic Activity ◽  
Estrogen Receptor Α ◽  
Activation Assay ◽  
Human Estrogen Receptor

Oxysterol Regulation of Estrogen Receptor α-Mediated Gene Expression in a Transcriptional Activation Assay System Using HeLa Cells

2004 ◽  
Vol 68 (8) ◽  
pp. 1790-1793 ◽  
Author(s):  
Hiroyoshi SATO ◽  
Satoko NISHIDA ◽  
Hiroko TOMOYORI ◽  
Masao SATO ◽  
Ikuo IKEDA ◽  
...  
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Hela Cells ◽  
Transcriptional Activation ◽  
Estrogen Receptor Α ◽  
Assay System ◽  
Activation Assay

scholarly journals Functional characterization of somatic point mutations of the human estrogen receptor α (hERα) in adenomyosis uteri

2004 ◽  
Vol 10 (12) ◽  
pp. 853-860 ◽  
Author(s):  
Martin K. Oehler ◽  
Holger Greschik ◽  
Dagmar-C. Fischer ◽  
Xiaowen Tong ◽  
Roland Schuele ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Functional Characterization ◽  
Point Mutations ◽  
Estrogen Receptor Α ◽  
Human Estrogen Receptor

Biophysical studies of the interaction between calmodulin and the R287-T311 region of human estrogen receptor α reveals an atypical binding process

2012 ◽  
Vol 419 (2) ◽  
pp. 356-361 ◽  
Author(s):  
Ludovic Carlier ◽  
Cillian Byrne ◽  
Emeric Miclet ◽  
Sandrine Bourgoin-Voillard ◽  
Magali Nicaise ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Binding Process ◽  
Biophysical Studies ◽  
Human Estrogen Receptor

scholarly journals Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

2020 ◽  
Author(s):  
Shivani N. Mann ◽  
Niran Hadad ◽  
Molly Nelson-Holte ◽  
Alicia R. Rothman ◽  
Roshini Sathiaseelan ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Chronic Diseases ◽  
Transcriptional Activation ◽  
Estrogen Receptor Α ◽  
Metabolic Parameters ◽  
Metabolic Effects ◽  
Male Rats ◽  
Male Mice ◽  
Dietary Interventions ◽  
Estradiol Treatment

ABSTRACTMetabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves metabolic parameters and slows aging in male mice. The mechanisms by which 17α-estradiol elicits these benefits remain unresolved. Herein, we show that 17α-estradiol elicits similar genomic binding and transcriptional activation through estrogen receptor α (ERα) to that of 17β-estradiol. In addition, we show that the ablation of ERα completely attenuates the beneficial metabolic effects of 17α-E2 in male mice. Our findings suggest that 17α-E2 acts primarily through the liver and hypothalamus to improve metabolic parameters in male mice. Lastly, we also determined that 17α-E2 improves metabolic parameters in male rats, thereby proving that the beneficial effects of 17α-E2 are not limited to mice. Collectively, these studies suggest ERα may be a drug target for mitigating chronic diseases in male mammals.

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