scholarly journals Tubeimoside-1 suppresses breast cancer metastasis through downregulation of CXCR4 chemokine receptor expression

BMB Reports ◽  
2016 ◽  
Vol 49 (9) ◽  
pp. 502-507 ◽  
Author(s):  
Yaojin Peng ◽  
Yan Zhong ◽  
Gao Li
Keyword(s):  
Breast Cancer ◽  
Chemokine Receptor ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Receptor Expression ◽  
Chemokine Receptor Expression

Effect of pro-inflammatory cytokine stimulation on human breast cancer: Implications of chemokine receptor expression in cancer metastasis

2009 ◽  
Vol 283 (2) ◽  
pp. 176-185 ◽  
Author(s):  
Julio E. Valdivia-Silva ◽  
Janusz Franco-Barraza ◽  
Ana Luisa Esparza Silva ◽  
Gisela Du Pont ◽  
Gloria Soldevila ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chemokine Receptor ◽  
Human Breast Cancer ◽  
Inflammatory Cytokine ◽  
Cancer Metastasis ◽  
Receptor Expression ◽  
Human Breast ◽  
Chemokine Receptor Expression ◽  
Cytokine Stimulation

scholarly journals The Role of CCL21/CCR7 Chemokine Axis in Breast Cancer Progression

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1036 ◽  
Author(s):  
Balsam Rizeq ◽  
Mohammed Imad Malki
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Chemokine Receptor ◽  
Chemokine Receptors ◽  
Cancer Metastasis ◽  
Cellular Proliferation ◽  
Inflammatory Diseases ◽  
Breast Cancer Metastasis ◽  
Breast Cancer Progression ◽  
Cellular Interactions

Breast cancer is a leading cause of cancer-related deaths worldwide, predominantly caused by metastasis. It is generally accepted that the pattern of breast cancer metastasis is largely determined by the interaction between the chemokine receptors on cancer cells and the chemokines expressed at the sites of metastatic disease. Chemokine receptors belong to the G-protein-coupled receptors (GPCRs) family that appear to be implicated in inflammatory diseases, tumor growth and metastasis. One of its members, C-C Chemokine receptor 7 (CCR7), binds chemokines CCL19 and CCL21, which are important for tissue homeostasis, immune surveillance and tumorigenesis. These receptors have been shown to induce the pathobiology of breast cancer due to their ability to induce cellular proliferation and migration upon the binding of the cognate chemokine receptors. The underlying signaling pathways and exact cellular interactions within this biological system are not fully understood and need further insights. Thus, in this review, we summarize the essential roles of CCR7 and its receptors in breast cancer progression. Furthermore, we discuss the mechanisms of regulation that may lead to novel opportunities for therapeutic intervention. Despite the enormous advances in our knowledge of the nature of the chemokines in breast cancer metastasis, research about the involvement of CCR7 in cancer progression is still limited. Therefore, further studies are essential to illustrate the distinct roles of CCR7 in cancer progression and validate its potential as a preventive bio-factor for human breast cancer metastasis by targeting chemokine receptor genes.

O-98 Role of the chemokine receptor CXCR4 in breast cancer metastasis

2007 ◽  
Vol 5 (3) ◽  
pp. 30
Author(s):  
M.I. Ahmed ◽  
J.R. Harvey ◽  
J. Kirby ◽  
S. Ali ◽  
T.W.J. Lennard
Keyword(s):  
Breast Cancer ◽  
Chemokine Receptor ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Chemokine Receptor Cxcr4

scholarly journals Forkhead box C1 boosts triple‐negative breast cancer metastasis through activating the transcription of chemokine receptor‐4

2018 ◽  
Vol 109 (12) ◽  
pp. 3794-3804 ◽  
Author(s):  
Hongchao Pan ◽  
Zhilan Peng ◽  
Jiediao Lin ◽  
Xiaosha Ren ◽  
Guojun Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Chemokine Receptor ◽  
Cancer Metastasis ◽  
Triple Negative ◽  
Breast Cancer Metastasis ◽  
Forkhead Box ◽  
Chemokine Receptor 4

scholarly journals Curcumae Radix Extract Decreases Mammary Tumor-Derived Lung Metastasis via Suppression of C-C Chemokine Receptor Type 7 Expression

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 410 ◽  
Author(s):  
Pelin Kaya ◽  
Sang Lee ◽  
Young Lee ◽  
Sun Kwon ◽  
Hyun Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Mammary Tumor ◽  
Chemokine Receptor ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Receptor Type ◽  
Primary Breast Tumor ◽  
Mcf7 Cells ◽  
Metastatic Activity

Curcumae radix is the dry root of Curcuma longa L. (turmeric) that can be used either as a spice or traditional medicine. The aim of this study was to investigate the survival benefits and the anti-metastatic activity of curcumae radix extract (CRE) in MCF7 cells and in MMTV-PyMT transgenic mice—a mouse model of breast cancer metastasis. In vitro wound scratch assay revealed that CRE treatment inhibited cell motility and cell migration in a dose-dependent manner. To investigate the effect of CRE in breast cancer metastasis, MMTV-PyMT transgenic female virgin mice were used and randomly divided into two groups. For survival curve analysis, CRE was administered in a dose of 50 mg/kg to 8–20-week-old mice. Interestingly, CRE treatment significantly increased the median and prolonged survival of MMTV-PyMT mice. Furthermore, CRE treatment decreased tumor burden and inhibited cell proliferation in primary breast tumor, and also suppressed mammary tumor-derived lung metastasis. The size of the lung metastases substantially decreased in the CRE-treated group compared with the ones in the control group. Curcumae radix extract showed anti-metastatic activity through regulating the expression of metastasis markers including C-C Chemokine Receptor Type 7, Matrix Metalloproteinase 9 and the proto-oncogenes c-fos and c-jun. We demonstrated that these metastatic regulators were decreased when CCR7 expression was suppressed in MCF7 cells transfected with CCR7 siRNA. The results of this study show that curcumae radix exerts antitumor and anti-metastatic activities, and we suggest that curcumae radix might be a potential supplement for the treatment and prevention of breast cancer metastasis.

scholarly journals Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Gardiyawasam Kalpana ◽  
Christopher Figy ◽  
Miranda Yeung ◽  
Kam C. Yeung
Keyword(s):  
Breast Cancer ◽  
Primary Tumor ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Tumor Formation ◽  
Receptor Expression ◽  
Mechanistic Study ◽  
Metastasis Suppressor ◽  
Primary Tumors

Abstract The role of RhoA GTPases in breast cancer tumorigenesis and metastasis is unclear. Early studies within which mutations in RhoA were designed based on cancer-associated mutations in Ras supported an oncogene role for RhoA. However, recent whole-genome sequencing studies of cancers raised the possibility that RhoA may have a tumor suppression function. Here, using a syngeneic triple negative breast cancer murine model we investigated the physiological effects of reduced RhoA expression on breast cancer tumorigenesis and metastasis. RhoA knockdown had no effect on primary tumor formation and tumor proliferation, concurring with our in vitro findings where reduced RhoA had no effect on breast cancer cell proliferation and clonogenic growth. In contrast, primary tumors with RhoA knockdown efficiently invaded sentinel lymph nodes and significantly metastasized to lungs compared to control tumors. Mechanistically, the current study demonstrated that this is achieved by promoting a pro-tumor microenvironment, with increased cancer-associated fibroblasts and macrophage infiltration, and by modulating the CCL5-CCR5 and CXCL12-CXCR4 chemokine axes in the primary tumor. To our knowledge, this is the first such mechanistic study in breast cancer showing the ability of RhoA to suppress chemokine receptor expression in breast tumor cells. Our work suggests a physiological lung and lymph node metastasis suppressor role for RhoA GTPase in breast cancer.

Sign in / Sign up

Export Citation Format

Share Document