scholarly journals Robotic single-site staging operation for early-stage endometrial cancer: initial experience at a single institution

2019 ◽  
Vol 62 (3) ◽  
pp. 149 ◽  
Author(s):  
Hyewon Chung ◽  
Tae-Kyu Jang ◽  
Seung Hyub Nam ◽  
Sang-Hoon Kwon ◽  
So-Jin Shin ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Single Site ◽  
Initial Experience ◽  
Single Institution ◽  
Early Stage Endometrial Cancer ◽  
Staging Operation

Adjuvant Vaginal Cuff Brachytherapy for High-Risk, Early Stage Endometrial Cancer: A Single-Institution Experience

Brachytherapy ◽  
2014 ◽  
Vol 13 ◽  
pp. S77-S78
Author(s):  
Harriet B. Eldredge-Hindy ◽  
Rani Pramila Anne ◽  
Gary Eastwick ◽  
Norman Rosenblum ◽  
Russell J. Schilder ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
High Risk ◽  
Early Stage ◽  
Single Institution ◽  
Vaginal Cuff ◽  
Early Stage Endometrial Cancer

Robotic Single-Site Surgery in Management of Obese Patients With Early-Stage Endometrial Cancer

2015 ◽  
Vol 22 (4) ◽  
pp. 697-699 ◽  
Author(s):  
Stefano Bogliolo ◽  
Chiara Cassani ◽  
Valentina Musacchi ◽  
Luciana Babilonti ◽  
Barbara Gardella ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Single Site ◽  
Obese Patients ◽  
Early Stage Endometrial Cancer ◽  
Single Site Surgery

scholarly journals Prognosis Stratification Tools in Early-Stage Endometrial Cancer: Could We Improve Their Accuracy?

2021 ◽  
Author(s):  
Jorge Luis Ramon-Patino ◽  
Ignacio Ruz-Caracuel ◽  
Victoria Heredia-Soto ◽  
Luis Eduardo Garcia de la Calle ◽  
Bulat Zagidullin ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Molecular Classification ◽  
Single Institution ◽  
Free Survival ◽  
Prognostic Groups ◽  
Prognostic Stratification ◽  
Stage Ia ◽  
Improved Accuracy ◽  
Early Stage Endometrial Cancer

Abstract BackgroundThere are 3 prognostic stratification tools used in clinics for endometrial cancer: ESMO-ESGO-ESTRO 2016, ProMisE, and ESGO-ESTRO-ESP 2020. However, these methods are not sufficiently accurate to address the prognosis and adjuvant therapy. Some other previously explored biomarkers have also shown prognostic relevance. The aim of this study was to investigate whether the integration of molecular classification and other biomarkers could be used to refine the prognosis in early-stage endometrial cancer. MethodsThis was a retrospective single-institution cohort of patients with early-stage endometrial cancer to evaluate these stratification tools. Relapse-free survival (RFS) and overall survival of each classifier were analysed, and the c-index was employed to assess accuracy. Other biomarkers were explored to improve the precision of risk classifiers.ResultsWe analysed 294 patients: 88% had endometrioid histology, 69% stage Ia, and 15% had a relapse. A comparison between the 3 classifiers showed a slightly improved accuracy in ESGO-ESTRO-ESP 2020 when RFS was evaluated (c-index = 0.79), although we did not find differences between intermediate prognostic groups. However, the inclusion of CTNNB1 status to stratify patients of intermediate groups allowed a better discrimination between the intermediate prognostic groups, resulting in a c-index of 0.82. Therefore, we propose a novel classifier based on ESGO-ESTRO-ESP 2020 and CTNNB1, which achieved statistically significant and clinically relevant differences in 5-year RFS: 93.4% for low risk, 79.6% for intermediate merged group/CTNNB1 wild type, and 37.3% for high risk (including patients from the merged intermediate groups with CTNNB1 mutation).ConclusionsThe incorporation of molecular classification in risk stratification of endometrial cancer resulted in better discriminatory capability, which was improved even further with the addition of CTNNB1 mutational evaluation.

Laparoendoscopic Single-Site Versus Conventional Laparoscopic Surgical Staging for Early-Stage Endometrial Cancer

2014 ◽  
Vol 24 (2) ◽  
pp. 358-363 ◽  
Author(s):  
Jeong-Yeol Park ◽  
Dae-Yeon Kim ◽  
Dae-Shik Suh ◽  
Jong-Hyeok Kim ◽  
Joo-Hyun Nam
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Early Stage ◽  
Pelvic Lymph Node Dissection ◽  
Single Site ◽  
Surgical Staging ◽  
Node Dissection ◽  
Conventional Laparoscopic ◽  
Laparoendoscopic Single Site ◽  
Early Stage Endometrial Cancer

ObjectiveThis study aims to compare the feasibility, safety, and efficacy of laparoendoscopic single-site (LESS) surgical staging for early-stage endometrial cancer with conventional laparoscopic surgical staging.Materials and MethodsThe prospective study group consisted of 37 consecutive patients who underwent LESS surgical staging including hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection. The historical control group consisted of 74 consecutive patients who underwent 4-port laparoscopic surgical staging including hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection. Surgical outcomes were compared between the 2 groups.ResultsNo patient in the LESS or conventional laparoscopic surgery group required an additional trocar or conversion to laparotomy. There were no intergroup differences in mean age, menopause status, body mass index, and previous history of abdominal surgery. Further, there were no inter-group differences in the number of total (LESS vs. conventional, 25.9 ± 10.6 vs. 24.6 ± 9.0, P = 0.497), pelvic (24.6 ± 0.497 vs. 23.3 ± 7.7, P = 0.459), and para-aortic (4.9 ± 2.5 vs. 6.9 ± 7.3, P = 0.494) lymph nodes retrieved; the operating time (183 ± 50 min vs. 173 ± 106, P = 0.388); estimated blood loss (194 ± 149 mL vs. 173 ± 106 mL, P = 0.394); number of patients requiring transfusion (5.4% vs. 8.1%, P = 0.717); postoperative hospital stay (5.0 ± 1.8 days vs. 5.1 ± 1.8 days, P = 0.911); intraoperative complications (2.7% vs. 0%, P = 0.333); and postoperative complications (0% vs. 1.4%, P > 0.999). The postoperative pain scores and analgesic requirements were significantly lower in the LESS surgical staging group.ConclusionsLaparoendoscopic single-site surgical staging was a feasible, safe, and efficacious procedure for surgical management of early-stage endometrial cancer. It was associated with less postoperative pain and analgesic requirements and was comparable to conventional laparoscopic surgical staging in perioperative outcomes.

The Patient and Observer Scar Assessment Scale to Evaluate the Cosmetic Outcomes of the Robotic Single-Site Hysterectomy in Endometrial Cancer

2018 ◽  
Vol 28 (1) ◽  
pp. 194-199 ◽  
Author(s):  
Giacomo Corrado ◽  
Gloria Calagna ◽  
Giuseppe Cutillo ◽  
Salvatore Insinga ◽  
Emanuela Mancini ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Intraoperative Complications ◽  
Pelvic Lymphadenectomy ◽  
Cosmetic Outcome ◽  
Assessment Scale ◽  
Single Site ◽  
Oncologic Surgery ◽  
Scar Assessment ◽  
Early Stage Endometrial Cancer

ObjectiveThe objective of this study was to evaluate the cosmetic outcome of robotic single-site hysterectomy (RSSH) in early-stage endometrial cancer.MethodsWe prospectively collected patient demographics, operative times, complications, pathologic results, and length of stay on all patients who underwent RSSH for early-stage endometrial cancer. The Patient and Observer Scar Assessment Scale (POSAS) was used for the evaluation of the cosmetic outcome.ResultsForty-five patients were included in our study from January 2012 to October 2015. The median age of patients was 63 years (range, 35–84 years), and the median body mass index was 26.5 kg/m2 (range, 18–39 kg/m2). No laparoscopic/laparotomic conversion was registered. The median docking time, console time, and total operative time were 7 minutes (range, 4–14 minutes), 46 minutes (range, 20–100 minutes), and 90 minutes (range, 45–150 minutes), respectively. The median blood loss was 50 mL (range, 10–150 mL). Nine patients underwent pelvic lymphadenectomy, and the median number of pelvic lymph nodes was 13 (range, 10–32). The median time to discharge was 3 days (range, 2–6 days). No intraoperative complications occurred, whereas we did observe 1 early postoperative complication. The oncological outcome was directly comparable to the literature. Patients reported low pain scores and high satisfaction in terms of postoperative scarring. The POSAS scores confirmed excellent cosmetic outcome of RSSH.ConclusionRobotic single-site hysterectomy provided an efficient option for gynecologic oncologic surgery. The POSAS revealed high objective and patient-evaluated outcome, and patients were highly satisfied with the overall outcome of the appearance of their scars.

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