scholarly journals Assessment of booster vaccination with hepatitis B vaccine using predominant usage of TCR Vbeta genes

2021 ◽  
Vol 10 (1) ◽  
pp. 1
Author(s):  
Jianwei Zhou ◽  
Yizhao Li ◽  
Yu Li
Keyword(s):  
Hepatitis B ◽  
Booster Vaccination ◽  
Hepatitis B Vaccine

scholarly journals Effects of hepatitis B vaccine boosters in different levels of epidemic areas on anti-HBs-negative children after primary vaccination

2020 ◽  
Author(s):  
Lu Zhu ◽  
Kangli Ye ◽  
Yuanyuan Zheng ◽  
Yan Qiu ◽  
Zikang Wu ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Booster Vaccination ◽  
Primary Vaccination ◽  
Hepatitis B Vaccine ◽  
Booster Immunization ◽  
Group Iii ◽  
Group I ◽  
Epidemic Area ◽  
High Prevalence ◽  
Different Levels

Introduction. The widespread of hepatitis B virus is a severe global public problem, and the infant hepatitis B vaccine has been proved effective. But the failure of the immune response was reported in studies, and boosters were recommended. There were few studies about the effect of hepatitis B vaccine boosters in different levels of the epidemic area. Hypothesis. Booster immunization is recommended because there may be a lack of immunization in infants vaccinated with the hepatitis B vaccine. In order to verify the effectiveness of booster immunization, this study hypothesized that it worked well in different levels of endemic areas. Aim. To evaluate the effects of hepatitis B vaccine boosters on children from the areas with different prevalence of hepatitis B whose hepatitis B surface antibody (anti-HBs) were negative (<10 mIU ml−1). Methodology. A total of 940 children were initially enrolled in screening; however, 421 were excluded. The participants were divided into three groups according to the different areas they come from: group I, low epidemic area; group II, middle epidemic area; and group III, high epidemic area. In total, 519 subjects were administered three doses of booster hepatitis B vaccine (0–1–6 months, 10 µg). The antibody titre changes were examined at four time points: 1 month after dose 1, 1 month, 1 year and 5 years after dose 3. Results. The protective seroconversion rates in three groups were 96.30, 97.16, 96.63% at 1 month after dose 1, and 100.00, 100.00, 100.00% at 1 month after dose 3, and 97.79, 100.00, 98.50% at 1 year after dose 3, and 90.77, 93.67, 93.59% at 5 years after dose 3 (P>0.05). Conclusions. This study demonstrates that three doses of booster vaccination have a longtime effect, no matter whether it is in low, middle or high prevalence areas in which subjects live.

Booster vaccination with recombinant hepatitis B vaccine four years after priming with one single dose

Vaccine ◽  
1999 ◽  
Vol 17 (17) ◽  
pp. 2162-2165 ◽  
Author(s):  
Johan Wiström ◽  
Clas Ahlm ◽  
Sonia Lundberg ◽  
Bo Settergren ◽  
Arne Tärnvik
Keyword(s):  
Single Dose ◽  
Hepatitis B ◽  
Booster Vaccination ◽  
Hepatitis B Vaccine ◽  
Recombinant Hepatitis

scholarly journals Hepatitis B Vaccine Non-Responders Show Higher Frequencies of CD24highCD38high Regulatory B Cells and Lower Levels of IL-10 Expression Compared to Responders

2021 ◽  
Vol 12 ◽  
Author(s):  
Nina Körber ◽  
Laureen Pohl ◽  
Birgit Weinberger ◽  
Beatrix Grubeck-Loebenstein ◽  
Andrea Wawer ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
B Cells ◽  
Hepatitis B ◽  
Booster Vaccination ◽  
Hepatitis B Vaccine ◽  
Third Generation ◽  
Regulatory B Cells ◽  
Expression Levels ◽  
Booster Immunization ◽  
Hepatitis B Vaccines

BackgroundThe cellular mechanisms involved in the lack of protective antibody response after hepatitis B vaccination are still rather unclear. Regulatory B cells (Breg) known as modulators of B-and T-cell responses may contribute to poor vaccine responsiveness. The current study aimed to investigate the role of regulatory B cells (Breg) in hepatitis B vaccine non-responsiveness after immunization with second- or third-generation hepatitis B vaccines.MethodWe performed comparative phenotypic and frequency analysis of Breg subsets (CD24+CD27+ and CD24highCD38high Breg) in second-generation hepatitis B vaccine non-responders (2nd HBvac NR, n = 11) and responders (2nd HBvac R, n = 8) before (d0), on day 7 (d7), and 28 (d28) after booster vaccination. Cryopreserved peripheral blood mononuclear cells were stimulated ex vivo with a combination of CpG, PMA, and Ionomycin (CpG+P/I) and analyzed for numbers and IL-10 expression levels of Breg by flow cytometry-based analyses.ResultsFlow cytometry-based analyses revealed elevated frequencies of CD24+CD27+ Breg at all time points and significantly higher frequencies of CD24highCD38high Breg on d0 (p = 0.004) and 28 (p = 0.012) in 2nd HBvac NR compared to 2nd HBvac R. In parallel, we observed significantly lower levels of CpG+P/I-induced IL-10 expression levels of CD24+CD27+ and CD24highCD38high Breg (d0: p &lt; 0.0001; d7: p = 0.0004; d28: p = 0.0003 and d0: p = 0.016; d7: p = 0.016, respectively) in 2nd HBvac NR compared to 2nd HBvac R before and after booster immunization. Frequencies of CD24+CD27+ and CD24highCD38high Breg significantly decreased after third-generation hepatitis B booster vaccination (d7: p = 0.014; d28: p = 0.032 and d7: p = 0.045, respectively), whereas IL-10 expression levels of both Breg subsets remained stable.ConclusionHere we report significantly higher frequencies of CD24highCD38high Breg in parallel with significantly lower IL-10 expression levels of CD24+CD27+ and CD24highCD38high Breg in 2nd HBvac NR compared to 2nd HBvac R. Anti-HBs seroconversion accompanied by a decrease of Breg numbers after booster immunization with a third-generation hepatitis B vaccine could indicate a positive effect of third-generation hepatitis B vaccines on Breg-mediated immunomodulation in hepatitis B vaccine non-responders.

Long-term antibody persistence after booster vaccination with combined tetravalent diphtheria, tetanus, whole-cellBordetella pertussisand hepatitis B vaccine in healthy infants

1997 ◽  
Vol 17 (4) ◽  
pp. 301-308 ◽  
Author(s):  
Yong Poovorawan ◽  
Apiradee Theamboonlers ◽  
Suvimol Sanpavat ◽  
Saowani Chumdermpadetsuk ◽  
Assad Safary ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Booster Vaccination ◽  
Hepatitis B Vaccine ◽  
Antibody Persistence ◽  
Healthy Infants

The effects of booster vaccination of hepatitis B Vaccine on anti-HBV surface antigen negative children 11-15 years after primary vaccination

2011 ◽  
Vol 7 (10) ◽  
pp. 1055-1059 ◽  
Author(s):  
Jun Yao ◽  
Jingjing Ren ◽  
Lingzhi Shen ◽  
Yongdi Chen ◽  
Xiaofeng Liang ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Booster Vaccination ◽  
Primary Vaccination ◽  
Hepatitis B Vaccine
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