Evaluation of the effects of Aqueous Extract of Parkinsonia aculeata Leaves on Kidney and Liver Function Indices in Albino Rats

2018 ◽  
Vol 26 (2) ◽  
pp. 76
Author(s):  
Shaayau Shehu ◽  
Hassan Ahmed ◽  
Abubakar Sani
Keyword(s):  
Liver Function ◽  
Aqueous Extract ◽  
Albino Rats ◽  
Parkinsonia Aculeata

Parkinsonia aculeata L. aqueous extract alleviated the hepatotoxicity induced by acetaminophen in albino rats

2020 ◽  
Vol 29 (3) ◽  
pp. 653-659
Author(s):  
Shimaa A. Elgaml ◽  
Wafaa H. B. Hassan ◽  
Sahar Abdelaziz ◽  
Emad A. Hashish
Keyword(s):  
Aqueous Extract ◽  
Albino Rats ◽  
Parkinsonia Aculeata

Impact of cefepime on hematological, immunological and oxidant/antioxidant parameters in rats experimentally infected with E. coli ATCC 25922

2020 ◽  
Vol 21 (1) ◽  
pp. 36-45
Author(s):  
Huda Elbaz ◽  
Mohamed Hamed ◽  
Fatma Abdelhamid ◽  
Osama Abdalla
Keyword(s):  
Liver Function ◽  
Oxidative Damage ◽  
Hemoglobin Concentration ◽  
Treated Group ◽  
Serum Glucose ◽  
Infected Group ◽  
Fixed Dose ◽  
Albino Rats ◽  
Immunological Parameters ◽  
Antioxidant Parameters

Objective: To evaluate the effect of cefepime on hematological changes, immunological disorders and hepatic oxidative damage in rats experimentally infected with E.coli ATCC 25922. Design: Randomized controlled experimental study. Animals: Thirty-two adult male albino rats weighting150-200 g. Procedures: Rats used for this study were randomly assigned into 4 equal groups: the control one, E.coli infected group (1×108CFU/I/P/once), the cefepime treated group (45 mg/kg bw/I/M/day) for 5 days and the E.coli infected group that treated with cefepime 24h after bacterial inoculation as previously described. Hematological and immunological parameters, liver function biomarkers and hepatic oxidative stress and antioxidant markers were determined. Results: Our result revealed that E.coli infection induced a significant elevation in the erythrocytes count, hemoglobin concentration, PCV% and total leukocytic count (TLC) (P < 0.05). In the same respect, liver function biomarkers, serum glucose, total cholesterol, and triglyceride levels as well hepatic malondialdehyde (MDA), nitric oxide (NO), TNF-α, IL-10, and lysozyme activity were significantly increased compared to the control rats (P < 0.05). In contrast, hepatic reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were decreased significantly (P < 0.05). Cefepime treatment in E.coli + CFPM group reduced the elevated eythrogram, TLC and liver function biomarkers. Cefepime also ameliorated the oxidative damage and inflammatory response induced by E.coli infection. Conclusion and clinical relevance: Cefepime is safe when administered in a fixed-dose and possess antioxidant that contributes to improve efficacy against adverse effect induced by E.coli ATCC 25922 infection.

Effect of cefepime on hematological, immunological and oxidant/antioxidant parameters in rats experimentally infected with E. coli ATCC 25922

2020 ◽  
Vol 21 (1) ◽  
pp. 36-45
Author(s):  
Huda Elbaz
Keyword(s):  
Liver Function ◽  
Oxidative Damage ◽  
Hemoglobin Concentration ◽  
Treated Group ◽  
Serum Glucose ◽  
Infected Group ◽  
Fixed Dose ◽  
Albino Rats ◽  
Immunological Parameters ◽  
Antioxidant Parameters

Objective: To evaluate the effect of cefepime on hematological changes, immunological disorders and hepatic oxidative damage in rats experimentally infected with E.coli ATCC 25922. Design: Randomized controlled experimental study. Animals: Thirty-two adult male albino rats weighting150-200 g. Procedures: Rats used for this study were randomly assigned into 4 equal groups: the control one, E.coli infected group (1×108CFU/I/P/once), the cefepime treated group (45 mg/kg bw/I/M/day) for 5 days and the E.coli infected group that treated with cefepime 24h after bacterial inoculation as previously described. Hematological and immunological parameters, liver function biomarkers and hepatic oxidative stress and antioxidant markers were determined. Results: Our result revealed that E.coli infection induced a significant elevation in the erythrocytes count, hemoglobin concentration, PCV% and total leukocytic count (TLC) (P < 0.05). In the same respect, liver function biomarkers, serum glucose, total cholesterol, and triglyceride levels as well hepatic malondialdehyde (MDA), nitric oxide (NO), TNF-α, IL-10, and lysozyme activity were significantly increased compared to the control rats (P < 0.05). In contrast, hepatic reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were decreased significantly (P < 0.05). Cefepime treatment in E.coli + CFPM group reduced the elevated eythrogram, TLC and liver function biomarkers. Cefepime also ameliorated the oxidative damage and inflammatory response induced by E.coli infection. Conclusion and clinical relevance: Cefepime is safe when administered in a fixed-dose and possess antioxidant that contributes to improve efficacy against adverse effect induced by E.coli ATCC 25922 infection.

scholarly journals Prevention of peptic ulcer by aqueous extract of Aegle marmelos leaf in rats

2018 ◽  
Vol 12 (1) ◽  
pp. 11-14
Author(s):  
Sharmin Rahman ◽  
Mohammad Rezaul Quader ◽  
Md Ismail Khan
Keyword(s):  
Body Weight ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Aqueous Extract ◽  
Protective Efficacy ◽  
Albino Rats ◽  
Ulcer Formation ◽  
Aegle Marmelos ◽  
Rat Stomach ◽  
Dose Dependent

Background and objectives: Aegle marmelos (Bael), a medicinal plant, has been widely used indigenously to treat many diseases in Bangladesh and other countries. The present study was carried out to evaluate the efficacy of A. marmelos leaf to prevent ethanol induced gastric ulcer in a rat model.Methods: Thirty two Wister albino rats of either sex, weighing between 100-150g, were fed 200 mg/kg or 400 mg/kg aqueous extract of A. marmelos leaves one hour prior to oral administration of 90% ethanol (1 ml/200 gm body weight) to induce gastric ulcer. The animals were sacrificed after one hour and ulcer scores and index were determined. The protective efficacy of A. marmelos aqueous extract was expressed as percentage protection of ulcer.Results: Aqueous extract exhibited significant (p<0.05) dose dependent protection against gastric ulcer formation by ethanol in rat stomach. Percentage protection of ulcer with 200 mg/kg and 400 mg/kg of aqueous extract of A. marmelos leave were 19.3% and 37.2% respectively compared to standard anti-peptic ulcer drug omeprazole (50.4%).Conclusion: Thus, crude extracts of A. marmelos leave have been shown to have potential ability to prevent experimentally induced peptic ulcer formation in animal model.IMC J Med Sci 2018; 12(1): 11-14

scholarly journals A STUDY OF THE EFFECT OF THE PHYTOCHEMICAL CONTENT OF P. AMERICANALEAF ON HEMATOLOGICAL SYSTEM OF ALBINO RATS

2021 ◽  
Vol 9 (04) ◽  
pp. 464-467
Author(s):  
Ngozi a ◽  
◽  
N. Omeke ◽  
Haruna M. Ndahi ◽  
◽  
...  
Keyword(s):  
Adverse Effect ◽  
Experimental Study ◽  
Aqueous Extract ◽  
Leaf Extract ◽  
Control Group ◽  
Albino Rats ◽  
Phytochemical Content ◽  
Other Substances ◽  
And Control ◽  
Experimental Group

Given the medicinal importance of the avocado plant in alternative medicine,the present study aimed to study the effect of the phytochemical content of P. americana leaf extract on the hematological system of albino rats. Albino rats were obtained andclustered into sixgroups,with five rats per groupsimultaneously were assigned experimental and control. The rats in the experimental group were administered with varying doses of the prepared aqueous extract of P. americanawithin the period of the study. The rats in the control group were administered with other substances such as water and feed for the study period.The hematological system of the experimental animal was assessed after the administration of the extract, and it was observed that the aqueous extract of P. americana leaf recorded no significant adverse effect on the hematology system of the experimental study animal.

Sign in / Sign up

Export Citation Format

Share Document