Comparison of the efficacy of Clove (Syzygium aromaticum) oil with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycemia in albino rats

2015 ◽  
Vol 3 (1) ◽  
pp. 169
Author(s):  
Chandralekha Netharakere ◽  
Nagendra Nayak ◽  
Vinodraj Kundapur ◽  
Nitasha Bhat ◽  
Paul Mathai ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Albino Rats ◽  
Syzygium Aromaticum

Protective effects of Syzygium aromaticum oil (Clove) against acrylamide induced hepatic, renal, and testicular toxicity in rats

2018 ◽  
Vol 6 (1) ◽  
pp. 12 ◽  
Author(s):  
Ashraf Elkomy ◽  
Mohamed Aboubakr ◽  
Samar Ibrahim ◽  
Yasmine Abdelhamid
Keyword(s):  
Oxidative Damage ◽  
Antioxidant Activities ◽  
Protective Role ◽  
Albino Rats ◽  
Syzygium Aromaticum ◽  
Testicular Toxicity ◽  
Protective Effects ◽  
Clove Oil ◽  
Organ Protection ◽  
Testicular Dysfunction

This study aimed to investigate the possible protective role of clove oil against acrylamide induced oxidative damage and impairment of liver, kidney, and testicular functions in albino rats. The apparent oxidative damage was associated with evident hepatic, renal, and testicular dysfunction, which was confirmed in histopathological lesions, and increased serum aspartate aminotransferase and alanine aminotransferase activities. Acrylamide decreased serum total protein and albumin contents; increased urea and creatinine contents. Acrylamide also reduced testosterone concentration. Treatment of acrylamide intoxicated rats with clove oil minimized liver, kidney, and testicular histopathological changes and normalized their functions. Our findings demonstrate that acrylamide is not only associated with hepatotoxicity but also nephrotoxicity and testicular toxicity. Clove oil administration provided substantial organ protection against hepatic, renal, and testicular dysfunction induced by acrylamide, which was possibly mediated through their antioxidant activities.   

Effect of Canagliflozin, an SGLT2 Inhibitor, in Comparison with Atorvastatin on Dexamethasone-Induced Hepatic Steatosis in Albino Rats

2020 ◽  
Vol 15 (3) ◽  
pp. 274-282
Author(s):  
Eman I. Ahmed ◽  
Amany M. Shaaban ◽  
Abdel Karim M. Abdel Latif
Keyword(s):  
Liver Disease ◽  
Hepatic Steatosis ◽  
Sglt2 Inhibitor ◽  
Fatty Degeneration ◽  
Treated Group ◽  
Control Group ◽  
Albino Rats ◽  
Alcoholic Fatty Liver ◽  
Beneficial Effects ◽  
Preventive Effects

Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that is considered the most common liver disease all over the world. It causes metabolic and hepatic damage that can progress to cirrhosis and hepatocellular carcinoma. Objective: Our research pointed to study the preventive effects of canagliflozin (CANA) or atorvastatin (ATO) on dexamethasone-induced hepatic steatosis and dyslipidemia. Methods: Animals were grouped as; control group; DEX group; ATO/DEX-treated group; CANA/DE-treated group and ATO+CANA/DEX-treated group. Results: Significant elevations in GSH, SOD and CAT activities, while high significant decreases in serum GOT, GPT, ALP, urea, blood glucose, CK-MB, LDH, T.G, T.C, MDA and P.C levels were demonstrated in treated groups as compared to DEX group in the experimental periods. Also, significant reductions in SGPT, SGPT, ALP, CK-MB, LDH, T.C and T.G levels were detected in CANA/DEX group as compared to ATO/DEX group. All these results were confirmed with histopathological findings where the severe damages and fatty degeneration in both kidney and liver tissues developed by dexamethasone administration resolved by administration of atorvastatin alone or better with Canagliflozin. Conclusion: These results indicate that canagliflozin was as effective as atorvastatin or combination of both in reducing dyslipidemia and hepatic steatosis. The antioxidant and hypolipidemic effects of canagliflozin may be responsible for the beneficial effects.

scholarly journals TOXICOLOGICAL SCREENING OF A NOVEL SIDDHA POLYHERBAL FORMULATION “SIRINGIPAERATHI CHOORANAM”

2019 ◽  
pp. 18-24
Author(s):  
VIJAYANIRMALA R. ◽  
ABINAYA R. ◽  
VELPANDIAN V.
Keyword(s):  
Acute Toxicity ◽  
Test Group ◽  
Saccharum Officinarum ◽  
The Body ◽  
Piper Nigrum ◽  
Albino Rats ◽  
Syzygium Aromaticum ◽  
Santalum Album ◽  
Piper Longum ◽  
Wistar Albino Rats

Objective: The aim of the present study is to validate the safety efficacy of “Siringipaerathi Chooranam” (SPC) in acute and sub-acute studies in the animal model. Methods: Siddha system of medicine is the one of the earliest systems of medicine, which was practiced by our spiritual scientists. It constitutes plants, animals, metals and mineral formulations. Chooranam are fine to dry powders of drugs. Hence I have preferred to choose “Siringipaerathi Chooranam” (SPC) which is indicated for hepatoprotective activity and it was prepared as per the classical Siddha literature. The adult wistar albino rats were used for acute toxicity for 14 d and sub-acute studies for 28 d as per OECD guidelines 423 and 407. The test drug was made Suspension with 2% CMC with uniform mixing and was administered to the groups of Wistar albino rats. The drugs were orally administered to the dosage in the levels of 100, 200 and 2000 mg/dose in acute and subacute studies. The ingredients of SPC are Inji (Zingiber officinalis), Milagu (Piper nigrum), Thippili (Piper longum), Thipili moolam (Root of Piper longum), Lavanga pathiri (Cinnamomum tamala),Elam (Elettaria cardamomum), Kodiveli ver (Plumbago zeylanica), Lavanga pattai (Cinnamomum zeylanicum), Moongil uppu (Bambusa arundinaceae), Sandhana thool (Santalum album), Vilamichu-ver (Plectranthus vettiveroides), Sathikkai (Myristica fragrans), Seeragam (Cuminum cyminum), Kirambu (Syzygium aromaticum), Sugar (Saccharum officinarum), Nei (Ghee). Results: The present investigation shows that there were no significant toxicity changes seen during the study. The body weight, food, water intake, behavioral, CNS, ANS, CVS, Vitals, Hematology, Biochemical and Histopathology of kidney, liver, spleen were observed both in control and test group animals were appears to be normal range. Conclusion: Thus the authors conclude from the results that the safety efficacy of SPC through acute and sub-acute toxicity studies in rodents.

Effectiveness of canagliflozin with atorvastatin on dexamethasone-induced dyslipidemia and hepatic steatosis in albino rats

2018 ◽  
Vol 13 (1) ◽  
pp. 246-258
Author(s):  
Amany M Shaaban ◽  
Eman I Ahmed ◽  
Abdel Karim M Abdel Latif
Keyword(s):  
Hepatic Steatosis ◽  
Albino Rats

scholarly journals Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycaemia in albino rats

2015 ◽  
Vol 47 (2) ◽  
pp. 181 ◽  
Author(s):  
K Vinodraj ◽  
IM Nagendra Nayak ◽  
JVikram Rao ◽  
Paul Mathai ◽  
N Chandralekha ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Albino Rats

Effects of renovascular hypertension on rat adrenal zona glomerulosa

1978 ◽  
Vol 36 (2) ◽  
pp. 582-583
Author(s):  
G. Mazzocchi ◽  
P. Rebuffat ◽  
C. Robba ◽  
P. Vassanelli ◽  
G. G. Nussdorfer
Keyword(s):  
Renovascular Hypertension ◽  
Left Kidney ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Zona Glomerulosa ◽  
Ultrastructural Changes ◽  
Albino Rats ◽  
Left Renal Artery ◽  
Angiotensin System ◽  
And Control

It is well known that the rat adrenal zona glomerulosa steroidogenic activity is controlled by the renin-angiotensin system. The ultrastructural changes in the rat zona glomerulosa cells induced by renovascular hypertension were described previously, but as far as we are aware no correlated biochemical and morphometric investigations were performed.Twenty adult male albino rats were divided into 2 experimental groups. One group was subjected to restriction of blood flow to the left kidney by the application of a silver clip about the left renal artery. The other group was sham-operated and served as a control. Renovascular hypertension developed in about 10 days: sistolic blood pressure averaged 165 ± 6. 4 mmHg, whereas it was about 110 ± 3. 8 mmHg in the control animals. The hypertensive and control rats were sacrificed 20 days after the operation. The blood was collected and plasma renin activity was determined by radioimmunological methods. The aldosterone concentration was radioimmunologically assayed both in the plasma and in the homogenate of the left capsular adrenal gland.

Further Studies on the Ultrastructure of Harderian Gland in Adult Rats

1974 ◽  
Vol 32 ◽  
pp. 288-289
Author(s):  
Alfredo Feria-Velasco ◽  
Guadalupe Tapia-Arizmendi
Keyword(s):  
Fine Structure ◽  
Domestic Fowl ◽  
Animal Species ◽  
Acinar Cells ◽  
Harderian Gland ◽  
Myoepithelial Cells ◽  
The Other ◽  
Albino Rats ◽  
Adult Rats ◽  
Cell Components

The fine structure of the Harderian gland has been described in some animal species (hamster, rabbit, mouse, domestic fowl and albino rats). There are only two reports in the literature dealing on the ultrastructure of rat Harderian gland in adult animals. In one of them the author describes the myoepithelial cells in methacrylate-embbeded tissue, and the other deals with the maturation of the acinar cells and the formation of the secretory droplets. The aim of the present work is to analize the relationships among the acinar cell components and to describe the two types of cells located at the perifery of the acini.

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