Comparison of levels of serum nitric oxide and asymmetric dimethylarginine levels in manic episodes in bipolar affective disorder before and after the treatment

2017 ◽  
pp. 1
Author(s):  
Ahmet Tiryaki ◽  
Demet Aykut ◽  
Evrim Karaguzel ◽  
Suleyman Karahan
Keyword(s):  
Nitric Oxide ◽  
Affective Disorder ◽  
Asymmetric Dimethylarginine ◽  
Bipolar Affective Disorder ◽  
Before And After

The role of the arginine-nitric oxide pathway in the pathogenesis of bipolar affective disorder

2004 ◽  
Vol 254 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Medaim Yanik ◽  
H�seyin Vural ◽  
Hamdi Tutkun ◽  
S�leyman Salih Zoroglu ◽  
Haluk Asuman Savas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Nitric Oxide Pathway

Possible Role of Nitric Oxide and Adrenomedullin in Bipolar Affective Disorder

2002 ◽  
Vol 45 (2) ◽  
pp. 57-61 ◽  
Author(s):  
Haluk A. Savaş ◽  
Hasan Herken ◽  
Muhittin Yürekli ◽  
Efkan Uz ◽  
Hamdi Tutkun ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Affective Disorder ◽  
Bipolar Affective Disorder

Nitric Oxide and Neopterin in Bipolar Affective Disorder

2006 ◽  
Vol 54 (1) ◽  
pp. 75-81 ◽  
Author(s):  
R. Hoekstra ◽  
D. Fekkes ◽  
L. Pepplinkhuizen ◽  
A.J.M. Loonen ◽  
S. Tuinier ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Affective Disorder ◽  
Bipolar Affective Disorder

scholarly journals Helicobacter pyloriEradication Lowers Serum Asymmetric Dimethylarginine Levels

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Selim Aydemir ◽  
Hacı Eren ◽  
Ishak Ozel Tekin ◽  
Ferda Akbay Harmandar ◽  
Nejat Demircan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vascular Tone ◽  
Asymmetric Dimethylarginine ◽  
Microbial Pathogens ◽  
Before And After ◽  
Nos Inhibitor ◽  
The Mean ◽  
H Pylori ◽  
Oxide Synthase ◽  
Regulation Of Vascular Tone

Introduction. Microbial pathogens, one of them isHelicobacter pylori(H. pylori), have frequently been implicated in the atherogenesis. Endothelium-derived nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS) and plays a pivotal role in the regulation of vascular tone. Asymmetric dimethylarginine (ADMA) is the most potent endogenous NOS inhibitor. Elevated levels of ADMA have been reported in many circumstances associated with a high cardiovascular risk. The aim of the present study was to investigate whether the eradication ofH. pyloriinfection affects serum ADMA levels.Materials and Methods. Forty-twoH. pylori-positive patients were enrolled in the study. Triple therapy for 14 days were given to all patients. Serum ADMA levels were measured at baseline and 2 months after therapy.Results. Eradication was achieved in 34 (81%) patients. The mean serum ADMA levels before and after therapy were and  ng/mL in the group withH. pylorieradicated and and  ng/mL in the noneradicated, respectively. We detected statistically significant decreased serum ADMA levels after therapy inH. pylorieradicated group.Conclusion. These findings have indicated that eradication ofH. pyloriinfection may decrease the risk of atherosclerosis and cardiovascular events.

scholarly journals Excessive Ultrafiltration During Hemodialysis Plays a Role in Intradialytic Hypertension Through Decreased Serum Nitric Oxide (NO) Level

2018 ◽  
Vol 11 (1) ◽  
pp. 60-71
Author(s):  
Yenny Kandarini ◽  
Ketut Suwitra ◽  
Raka Widiana
Keyword(s):  
Nitric Oxide ◽  
Significant Relationship ◽  
Direct Relationship ◽  
Asymmetric Dimethylarginine ◽  
Control Design ◽  
Serum Levels ◽  
Case Control ◽  
Adma Level ◽  
Before And After

Background: Intradialytic hypertension is one of many complications during Hemodialysis (HD). The mechanism of intradialytic hypertension is currently unclear. Objective: This research aims to understand the association between excessive Ultrafiltration (UF) and intradialytic hypertension episode and its relationship with changes in endothelin-1 level (ET-1), Asymmetric Dimethylarginine (ADMA) level and Nitric Oxide (NO) level during HD. Methods: This study utilized a case-control design. A sample of one hundred and eleven patients who were already undergoing maintenance HD for more than three months was included. Serum levels of NO, ET-1, and ADMA were examined before and after HD; samples were followed by as much as six times consecutive HD session, in which ultrafiltration and blood pressure during HD were noted. Results: From 112 samples obtained, 32.1% (36/112) had intradialytic hypertension. Using regression analysis, we found a significant association between changes in NO levels and intradialytic hypertension. We found a significant association between excessive UF and intradialytic hypertension (p=0.001), adjusted OR=5.17. Path analysis showed the existence of a significant relationship between UF volume during HD and intradialytic hypertension (CR 5.74; p<0.01), as well as a significant relationship between UF volume during HD and NO levels (CR -3.70: p<0.01). There was a direct relationship between NO serum levels with intradialytic hypertension (CR -7.08: p<0.01). Conclusion: Excessive UF during HD plays a role in intradialytic hypertension episode through decreased NO serum levels. There was no clear role of ADMA and ET-1 serum levels on intradialytic hypertension episode.

scholarly journals Local and Systemic Alterations of the L-Arginine/Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and Effects of Antibiotic Treatment

2020 ◽  
Vol 9 (12) ◽  
pp. 3802
Author(s):  
Beatrice Hanusch ◽  
Folke Brinkmann ◽  
Sebene Mayorandan ◽  
Kristine Chobanyan-Jürgens ◽  
Anna Wiemers ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cystic Fibrosis ◽  
Antibiotic Therapy ◽  
Acute Exacerbation ◽  
Antibiotic Treatment ◽  
Asymmetric Dimethylarginine ◽  
Lower Plasma ◽  
Lung Functions ◽  
Before And After ◽  
Lung Impairment

Alterations in the L-arginine (Arg)/nitric oxide (NO) pathway have been reported in cystic fibrosis (CF; OMIM 219700) as the result of various factors including systemic and local inflammatory activity in the airways. The aim of the present study was to evaluate the Arg/NO metabolism in pediatric CF patients with special emphasis on lung impairment and antibiotic treatment. Seventy CF patients and 78 healthy controls were included in the study. CF patients (43% male, median age 11.8 years) showed moderately impaired lung functions (FEV1 90.5 ± 19.1% (mean ± SD); 21 (30%) had a chronic Pseudomonas aeruginosa (PSA) infection, and 24 (33%) had an acute exacerbation). Plasma, urinary, and sputum concentrations of the main Arg/NO metabolites, nitrate, nitrite, Arg, homoarginine (hArg), and asymmetric dimethylarginine (ADMA) were determined in pediatric CF patients and in healthy age-matched controls. Clinical parameters in CF patients included lung function and infection with PSA. Additionally, the Arg/NO pathway in sputum samples of five CF patients was analyzed before and after routine antibiotic therapy. CF patients with low fractionally exhaled NO (FENO) showed lower plasma Arg and nitrate concentrations. During acute exacerbation, sputum Arg and hArg levels were high and dropped after antibiotic treatment: Arg: pre-antibiotics: 4.14 nmol/25 mg sputum vs. post-antibiotics: 2.33 nmol/25 mg sputum, p = 0.008; hArg: pre-antibiotics: 0.042 nmol/25 mg sputum vs. post-antibiotics: 0.029 nmol/25 mg sputum, p = 0.035. The activated Arg/NO metabolism in stable CF patients may be a result of chronic inflammation. PSA infection did not play a major role regarding these differences. Exacerbation increased and antibiotic therapy decreased sputum Arg concentrations.

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