Positive Pharmacological Effects of Methanolic Leaf Extract of Moringa oleifera on Some Liver and Kidney Functions and Oxidative Stress Markers in Sea Bream Sparus auratus L Exposed to Sodium Fluoride toxicity

2019 ◽  
Vol 63 (2) ◽  
pp. 142 ◽  
Author(s):  
Nasser Sabbagh ◽  
Medhat Shakweer ◽  
Hanan Ghetas
Keyword(s):  
Leaf Extract ◽  
Moringa Oleifera ◽  
Sea Bream ◽  
Pharmacological Effects ◽  
Fluoride Toxicity ◽  
Stress Markers ◽  
Liver And Kidney ◽  
Sparus Auratus ◽  
Kidney Functions ◽  
And Oxidative Stress

scholarly journals Ameliorative effects of Moringa oleifera on copper nanoparticle induced toxicity in Cyprinus carpio assessed by histology and oxidative stress markers

2018 ◽  
Vol 29 (46) ◽  
pp. 464003 ◽  
Author(s):  
Aasma Noureen ◽  
Farhat Jabeen ◽  
Tanveer A Tabish ◽  
Muhammad Kashif Zahoor ◽  
Muhammad Ali ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cyprinus Carpio ◽  
Moringa Oleifera ◽  
Copper Nanoparticle ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals Effect of Moringa oleifera aqueous leaf extract on hepato-renal changes of albino rats induced with Salmonella typhimurium

2017 ◽  
Vol 6 (4) ◽  
pp. 734
Author(s):  
Nasiru Suleiman ◽  
Bulama Ibrahim ◽  
Bagudo Ibrahim Ahmed ◽  
Attahiru Zayyanu
Keyword(s):  
Salmonella Typhimurium ◽  
Kidney Function ◽  
Total Protein ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Serum Alkaline Phosphatase ◽  
Albino Rats ◽  
Liver And Kidney ◽  
Group A ◽  
Aqueous Leaf Extract

Background: This study was designed to evaluate the effect of Moringa oleifera against Salmonella typhimurium infected changes in liver and kidney function parameters in albino rats.Methods: Twenty acclimatized albino rats were divided into four groups of five rats each (groups A-D). Groups B, C and D were exposed to 0.1ml (3.0x104 CFU) of Salmonella typhimurium. Six hours post- infection, Groups B and C were treated with 50 and 100mg/kg of Moringa oleifera aqueous leaf extract respectively and continued for 21 days. Group D was not treated while group A was neither infected nor treated. Serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), bilirubin, albumin, total protein, urea and creatinine were estimated using standard methods. All data were collected and analyzed in October 2015.Results: S. typhimurium infection significantly (p<0.05) increased the levels of ALP, ALT, AST, bilirubin, urea and creatinine when compared with control levels (Group A). Total protein and albumin concentrations were significantly (p<0.05) reduced following the infection. However, Moringa oleifera supplementation was associated with significant (p<0.05) decrease in the levels of ALP, ALT, AST, bilirubin, urea and creatinine. It is also associated with decrease in concentrations of total protein and albumin.Conclusions: This study showed S. typhimurium infection induced changes in liver and kidney function parameters and also revealed possible amelioratory effects to these changes after Moringa oleifera supplementation.

TOXICOLOGICAL IMPLICATIONS OF COMBINED CONSUMPTION OF HIGH FAT DIET AND ALCOHOL IN RATS

2018 ◽  
Vol 24 (2) ◽  
Author(s):  
HEMESHWER KUMAR CHANDRA ◽  
GITA MISHRA ◽  
NISHA SAHU ◽  
SATENDRA KUMAR NIRALA ◽  
MONIKA BHADAURIA
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Biochemical Parameters ◽  
Renal Toxicity ◽  
Control Group ◽  
High Fat ◽  
Stress Markers ◽  
Liver And Kidney ◽  
Serum Transaminases ◽  
And Oxidative Stress

The aim of the present study was to study the combined toxic effect of high fat diet and alcohol consumption on serological and oxidative stress markers in rats. Rats in control group received regular diet and water for 8 weeks, toxicant group were administered with 30% HFD and 10% alcohol for 2, 4, 6 and 8 weeks respectively.Combined consumption of high fat diet along with alcohol induced hepato-renal toxicity as evident by elevation of serum transaminases, alkaline phosphatase, bilirubin, cholesterol and triglycerides with significant decrease in glucose and albumin. Increased urea and uric acid was also seen in serum. Boosted lipid peroxidation and tissue biochemical parameters and decline in glutathione contents confirmed oxidative stress induced hepatorenal toxicity. Present study showed that 2, 4, 6 and 8 weeks administration of high fat diet along with alcohol significantly disturbed physiological integrity of liver and kidney.

scholarly journals Therapeutic Potential of Saffron (Crocus sativus L.) in Ischemia Stroke

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Shakiba Azami ◽  
Zahra Shahriari ◽  
Samira Asgharzade ◽  
Tahereh Farkhondeh ◽  
Mahmood Sadeghi ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Crocus Sativus ◽  
Pharmacological Effects ◽  
Oxidative Stress Markers ◽  
Neuroprotective Effects ◽  
Beneficial Effects ◽  
Stress Markers ◽  
Ancient Times ◽  
And Oxidative Stress ◽  
Crocus Sativus L

Stroke is the second leading cause of death and a main cause of disability worldwide. The majority (approximately 80%) of strokes are ischemic. Saffron (Crocus sativus L.) has been considered for medicinal purposes since ancient times. Pharmacological effects of saffron are attributed to the presence of crocin, crocetin, picrocrocin, and safranal. In the present review, we summarized the reported neuroprotective effects of saffron and its active constituents against cerebral ischemia stroke. Saffron and its components exert its beneficial effects as an antioxidant, anti-inflammatory, and antiapoptotic agent though inhibition of biochemical, inflammatory, and oxidative stress markers. Taken together, this review indicates that saffron and its ingredients could be a potent candidate in the process of new drug production for the treatment of ischemia stroke.

scholarly journals Ameliorative effect of vitamin C on cypermethrin-induced hepatotoxicity and renal malfunction of adult male rats.

2021 ◽  
Vol 14 ◽  
pp. 1-15
Author(s):  
Nessrin Kheirallah ◽  
Hussein K. Hussein ◽  
Horeya Abd El Gawad ◽  
Basma Youssef
Keyword(s):  
Vitamin C ◽  
Protective Role ◽  
Male Rats ◽  
Glucose Levels ◽  
Stress Markers ◽  
Ameliorative Effect ◽  
Liver And Kidney ◽  
Kidney Functions ◽  
Positive Effect

Cypermethrin is a widely used insecticide belongs to type II pyrethroids. It is highly used in developing countries to control many species of insects as it plays an important role in pest control. Vitamin C is an important intracellular antioxidant against insecticides. The aim of the present study is to analyze the toxic effects of cypermethrin (CYP) and the positive effect of vitamin C (VC) with graded doses (0 CYP, 200 VC, 12 CYP and 12 CYP+200 VC mg/kg body weight of male rats/day) for 30 days on liver and kidney functions. Moreover, antioxidant enzymes, oxidative stress markers, glycogen and glucose levels and also serum lipid profile were studied. Also, this study aimed to evaluate the possible protective role of vitamin C against cypermethrin toxicity

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