scholarly journals Extended curettage and reconstruction with proximal fibula for treating giant cell tumor of lateral femoral condyle: A prospective study

2017 ◽  
Vol 6 (4) ◽  
pp. 1
Author(s):  
Kuriakku Dominic ◽  
Davis Dijoe ◽  
Reghunathannair Aravind
Keyword(s):  
Prospective Study ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Femoral Condyle ◽  
Cell Tumor ◽  
Lateral Femoral Condyle ◽  
Proximal Fibula ◽  
Extended Curettage ◽  
A Prospective Study

scholarly journals Femoral Giant Cell Tumor in a Patient with Surgically Treated Femoral Condyle Fracture: Misdiagnosis or Coincidence?

2018 ◽  
Vol 1 (Supplement) ◽  
pp. 11
Author(s):  
I.M. Japie ◽  
A. Bădilă ◽  
T. Ciobanu ◽  
R. Manolescu ◽  
D. Rădulescu ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Bone Tumors ◽  
Femoral Condyle ◽  
Cell Tumor ◽  
Lateral Femoral Condyle ◽  
Musculoskeletal Tumor Society ◽  
Osteosynthesis Material ◽  
The Right ◽  
Condyle Fracture

Abstract Introduction. Giant-cell tumor of bone (GCTB) is a benign tumor with an unpredictable evolution, representing 4-5% of all primary bone tumors and 15% of benign bone tumors usually affecting 20-45 years old adults. The predilect location is the distal femur, proximal tibia, and distal radius. Case presentation. We report the case of a 31-year-old male, regardless of medical history, admitted in the emergency department (ED) for significant pain and functional impairment of the right knee, after suffering a traumatic event. Clinical examination and imaging tests established the diagnosis of lateral femoral condyle fracture. Therefore, osteosynthesis with 4 screws was performed. Postoperative evolution was uneventful until one year later when the patient presented to the ED for pain and inflammatory aspect of the right knee, but with no history of trauma during this time. The imagistic exams of the right knee (X-ray, magnetic resonance imaging and scintigraphy) detected a tumor of the lateral femoral condyle that also affected the osteosynthesis material. Thus, the removal of screws and histopathological exam were performed, the latter establishing the diagnosis of GCTB. Taking into consideration radiological and histological aspects of the tumor and relating them to the clinical findings, the GCTB was classified in stage III Enneking. The patient underwent surgery, segmental resection of the tumor in oncological limits and arthroplasty with modular tumoral prosthesis was performed. Postoperative results at 6 and 12 months according to Musculoskeletal Tumor Society Scoring System were very good. The key feature of this case consists of post-osteosynthesis appearance of the GCTB given the fact that only 3 cases of GCTB affecting the screw site were reported in literature.

scholarly journals A Case Report of Giant Cell Tumor of Proximal Fibula in Children

2020 ◽  
Vol 4 (1) ◽  
pp. 64-67
Author(s):  
Sushil Adhikari ◽  
Arun Sigdel ◽  
Rajesh Kumar Sah ◽  
Luna Devkota
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Long Bone ◽  
Lytic Lesion ◽  
Radiographic Appearance ◽  
X Ray ◽  
Proximal Fibula ◽  
Aggressive Tumor

Giant cell tumour (GCT) is histopathologically benign tumor of long bone particularly in distal femur and the proximal tibia. It commonly occurs in adults of age 20-40 years but rare in children. GCT is considered to be locally aggressive tumor and tendency of recurrence is higher even after surgery. The clinical features are nonspecific, the principle symptoms are pain, swelling and limiting adjacent joint movements. Diagnosis is based on the radiographic appearance and histopathological findings .In our case X-ray showed ill defined lytic lesion on proximal fibula with cortical thinning and MRI finding revealed expansile lyticlesion in meta-epiphysis of right fibula 16×16×28mm adjacent to growth plate with fluid level. The sclerotic rim appears hypo intense on T1 & hyper intense on T2. Core needle biopsy showed giant cell tumor on proximal fibula. Considering the risk of recurrence wide local excision was done. Management of GCT of proximal fibula in young patient is critical for preventing recurrence and enhancing functional outcomes by saving adjacent anatomical structure. No evidence of local recurrence and metastasis was found in 24 months of follow up.

Giant cell tumor of the proximal fibula: Surgical management

1996 ◽  
Vol 61 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Hosein Faezypour ◽  
Aileen M. Davis ◽  
Anthony M. Griffin ◽  
Robert S. Bell
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Surgical Management ◽  
Cell Tumor ◽  
Proximal Fibula

scholarly journals A posterior approach for curettage in giant cell tumor of bone in the proximal fibula

2019 ◽  
Vol 2019 (9) ◽  
Author(s):  
Akio Sakamoto ◽  
Takeshi Okamoto ◽  
Shuichi Matsuda
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Peroneal Nerve ◽  
Posterior Approach ◽  
En Bloc Resection ◽  
Cell Tumor ◽  
Knee Instability ◽  
En Bloc ◽  
Nerve Paralysis ◽  
Proximal Fibula

Abstract Giant cell tumor of bone (GCTB) is a locally aggressive tumor. En bloc resection to reduce the recurrence rate has a high risk of peroneal nerve paralysis and knee instability associated with collateral ligament resection. In the current report, the posterior approach to curettage is introduced in a 55-year-old male with GCTB in the proximal fibula. The approach makes a wide operative field for curettage of GCTB in the proximal fibula without dissecting the peroneal nerve. The approach would prevent postoperative peroneal nerve palsy and knee instability and possibly reduce recurrences.

scholarly journals Comparative Analysis of Two Surgical Treatment Options for Giant Cell Tumor of the Proximal Femur: Extended Curettage and Segmental Resection

2021 ◽  
Vol 11 ◽  
Author(s):  
Yuhao Yuan ◽  
Qing Liu ◽  
Yupeng Liu ◽  
Ziyi Wu ◽  
Wei Zhong ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Local Recurrence ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Recurrence Rate ◽  
Proximal Femur ◽  
Cell Tumor ◽  
Evaluation Standard ◽  
Msts Score ◽  
Extended Curettage

AimAs a locally destructive intermediate bone tumor with low incidence, high recurrence rate, and difficulty in reconstruction, giant cell tumor of bone (GCTB) in the proximal femur has no unified surgical treatment standard. This study aimed to compare the differences in local recurrence, reconstruction durability, and postoperative function after treatment with either extended curettage (EC) or segmental resection (SR) for GCTB in the proximal femur so as to provide constructive suggestions for the rational selection of EC or SR operation scheme.Patients and Methods29 patients (15 men and 14 women) were included in this retrospective study, with a mean age of 32.1 years. According to the division method of proximal femur of International Society Of Limb Salvage (ISOLS), there was 1 case in the H1 area, 17 cases in the H2 area, 10 cases in the H1+H2 area, and 1 case in the H1+H2+H3 area. Among them were 11 cases of Campanacci grade II GCTB, 18 cases of Campanacci grade III GCTB, and 7 cases with pathological fractures. All patients underwent either EC or SR surgery. The Musculoskeletal Tumor Society (MSTS) score was used for patient evaluation. The operation effectiveness was analyzed according to the Mankin evaluation standard. Regular follow-up was performed to evaluate the recurrence rate, limb function, and long-term complications of the two surgical methods.ResultsAll patients were followed up for a mean of 60.4 months. Local recurrence occurred in one of 19 patients treated with EC (5.3%) and one of 10 patients treated with SR (10%). The MSTS score of lower limb function in patients in the EC group was better compared to patients in the SR group (P = 0.002). Complications occurred in 2 cases (10.5%) and 5 cases (50%) in the EC group (osteoarthritis, osteonecrosis) and SR group (joint stiffness, infection, prosthesis loosening), respectively, with significant differences between the two groups (P = 0.03). The operation effectiveness was analyzed according to the Mankin evaluation standard. The EC group showed an optimal rate of 94.7% (18/19) as opposed to 80% (8/10) in the SR group.ConclusionsFor GCTB in the proximal femur, when the tumor does not extensively involves the surrounding soft tissues, the articular surface was not damaged, and there is no pathological fracture with apparent displacement, EC surgery should be fully considered.

scholarly journals Giant Cell Tumor Arising from Fibular Head in Immature Skeleton Treated with Marginal Excision

2018 ◽  
Vol 14 (3) ◽  
pp. 165-167
Author(s):  
Suresh Pandey
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Lateral Collateral Ligament ◽  
Cell Tumor ◽  
Proximal Fibula ◽  
Marginal Excision ◽  
Fourth Decade ◽  
Rare Site ◽  
Bony Lesion ◽  
Immature Skeleton

ABSTRACTGiant Cell tumor (GCT) is the benign tumor commonly found in second to fourth decade of life. Proximal fibula is very rare site and its occurrence in immature skeleton is still rare with very limited case report. We present a case of painful bony lesion arising from proximal fibula diagnosed as GCT in 15 year boy which was managed successfully with marginal excision and lateral collateral ligament anchorage in proximal tibia. There is no evidence of local recurrence,  lung metastasis, knee pain and instability till 24 months of follow up. Keywords: giant cell tumor; proximal fibula; marginal excision . 

scholarly journals Neoadjuvant and Adjuvant Treatment with Denosumab in Aggressive Giant-cell Tumor of Bone in the Proximal Fibula: a Case Report

Folia Medica ◽  
2018 ◽  
Vol 60 (4) ◽  
pp. 637-640 ◽  
Author(s):  
Violeta V. Marinova ◽  
Svetoslav A. Slavchev ◽  
Kircho D. Patrikov ◽  
Petya M. Tsenova ◽  
Georgi P. Georgiev
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Target Therapy ◽  
Osteolytic Lesion ◽  
Therapy Response ◽  
Surgical Excision ◽  
Cell Tumor ◽  
Treatment Modalities ◽  
Histological Changes ◽  
Proximal Fibula

Abstract Giant cell tumor of bone is a histologically benign but locally aggressive osteolytic lesion, capable of spreading ‘benign’ metastases mainly to the lungs. Since its description as a separate entity, surgery has been the mainstay of treatment. Recently, target therapy has been introduced using denosumab – an inhibitor antibody for the receptor activator of nuclear factor kappa B ligand with dramatic eff ect on the natural course of the tumor. Herein, we report a rare case of an aggressive stage 3 giant cell tumor of bone of the proximal fibula that was successfully downstaged using neoadjuvant denosumab treatment and then treated by surgical excision followed by adjuvant target therapy. The clinical characteristics and treatment modalities of giant cell tumor of bone, the indications for target therapy, therapy response, and histological changes are also briefly discussed.

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