scholarly journals Construction of mammographic findings simulators to study the interference of silicone implants in the diagnosis of breast cancer

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Lucila Franz Bezerra ◽  
Lenita Franz Bezerra ◽  
Kaiser Kruger ◽  
Everton Granemann Souza ◽  
Chiara Das Dores do Nascimento
Keyword(s):  
Breast Cancer ◽  
Malignant Neoplasm ◽  
Density Variation ◽  
Silicone Implants ◽  
Augmentation Mammoplasty ◽  
Dimensionless Unit ◽  
Pvc Film ◽  
The Individual ◽  
Two Stages ◽  
Made In

Introduction: Breast cancer is the most prevalent malignant neoplasm among women, presenting itself, in 99% of cases, in females. Augmentation mammoplasty is the most performed aesthetic surgical intervention in the world. Objective: This study aims to improve the search for biomaterials compatible with mammographic findings suggestive of malignancy, to further study the interference of silicone implants in mammography exams. Methods: To make the simulators of mammographic findings, a bibliographic study of possible biomaterials that presented compatibility with the breast tissue and with possible neoplastic findings was carried out. The validation process of the simulators made in this work was carried out in two stages. Results: The result found was a density variation between 2.54 and 2.57 (dimensionless unit). For the second plate, the individual optical density of each material was analyzed. The results found for fiberglass ranged between 1.95 and 2.63. For chicken eggshells between 0.59 and 0.80. For the glycerin suppository, values between 1.43 and 2.29 were found. And for plastic PVC film 1.78 to 2.53. Conclusion: Given the above, it is observed that the first plate as a whole is compatible with mammographic studies. However, on the second plate, when the materials were analyzed separately, it was observed that fiberglass and plastic PVC film were the closest to compatibility with the commercial phantom, being compatible materials to simulate breast neoplasms in possible further studies.

scholarly journals Project of an application to facilitate access to breast cancer diagnosis in Ceará

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
Luiz Gonzaga Porto Pinheiro ◽  
Márcio Marcondes Vieira ◽  
Paulo H D Vasques
Keyword(s):  
Breast Cancer ◽  
Early Diagnosis ◽  
Mammography Screening ◽  
Malignant Neoplasm ◽  
Breast Cancer Diagnosis ◽  
Target Population ◽  
Raising Awareness ◽  
Specialized Care ◽  
Advanced Stages ◽  
Made In

Breast cancer (BC) is the malignant neoplasm most associated with mortality among women in Ceará. Its survival rate is directly related to early diagnosis. Traditionally, this diagnosis is made after the self-detection of a nodule by the patient. Mammography screening covers 43% of the target population. The diagnosis is almost exclusively made in advanced stages, leading to high mortality (3735 deaths from 2013 to 2018). Raising awareness of the population is crucial to increase mammography coverage. The development of an application to refer suspected cases to a specialized care unit may increase the early diagnosis of the disease and improve its prognosis. The project consists of developing an application that directs women to get mammographies, increasing the care coverage, informing them about risk factors, helping them find reference centers, collecting data, and generating reports and predictions.

scholarly journals Breast cancer in patients after augmentation with implants

2021 ◽  
Vol 67 (4) ◽  
pp. 518-524
Author(s):  
Olga Khodorovich ◽  
Vladimir Solodkii ◽  
Alena Kalinina-Masri ◽  
Karen Sarkisian ◽  
Tatiana Sherstneva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Malignant Neoplasm ◽  
Aesthetic Surgery ◽  
Augmentation Mammoplasty ◽  
Morphological Examination ◽  
Definite Answer ◽  
Sufficient Detail ◽  
Cytogenetic Studies ◽  
Entire Complex ◽  
Mammographic Examination

Relevance. Currently, there is no definite answer to the question of the cause of breast cancer, since it is a systemic and multifactorial disease. Given that the number of aesthetic operations on the mammary glands using endoprostheses only increases every year, new cases of detection of malignant diseases do not decrease. Some researchers are beginning to speak out about the possible connection of augmentation mammoplasty in the anamnesis with the subsequent occurrence of breast cancer due to inadequate clinical and instrumental examination and ignoring some of its components (for example, the mammographic examination). Introduction. Taking into account the analysis of the literature and the presented clinical examples, the possible reasons for the connection of augmentation mammoplasty in the anamnesis with the subsequent detection of a malignant neoplasm are analyzed. Materials and methods. We analyzed domestic and foreign literature and described two clinical examples with authentic documentation based on the results of the examination and treatment. The article describes in detail the schemes of drug treatment and descriptions of the results of morphological examination of the surgical material. The types and results of surgical treatment with reliable photos are also presented. Results. Given the complexity of the diagnostic stage in patients with breast endoprosthesis in the described clinical examples, family history collected in sufficient detail, cytogenetic studies conducted, we should talk about the likely underdiagnosis during preventive examinations. Conclusion. The multifactorial and systematic nature of such a disease as breast cancer suggests that perhaps an intensive increase in the detectability of the above-mentioned against the background of previously performed aesthetic surgery would be the simplest solution to the problem. In this category of patients, anamnesis should be collected in more detail and carefully, and the entire complex of clinical and instrumental examinations, including mammography, magnetic resonance and ultrasound examinations, should be performed in order to fully diagnose and develop further patient management tactics.

BREAST CANCER AFTER AUGMENTATION MAMMOPLASTY. SURGICAL TACTICS

2018 ◽  
Vol 64 (6) ◽  
pp. 768-773
Author(s):  
Aziz Zikiryakhodzhaev ◽  
Erik Saribekyan ◽  
Natalya Ablitsova ◽  
Mariya Yermoshchenkova ◽  
Gadzhimurad Zapirov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Reconstruction ◽  
Surgical Approach ◽  
Silicone Implants ◽  
Augmentation Mammoplasty ◽  
Surgical Tactics

In recent years, an increasing number of cases of breast cancer in women after an earlier augmentation of the breast with the use of silicone implants. Diagnosis of tumors on the background of the implants and surgical approach are its essential features. Presents the experience on diagnosis and choice of adequate volume of removed tissues, and breast reconstruction in 10 patients is described.

An Information-theoretical Model for Breast Cancer Detection

2008 ◽  
Vol 47 (04) ◽  
pp. 322-327 ◽  
Author(s):  
D. Blokh ◽  
N. Zurgil ◽  
I. Stambler ◽  
E. Afrimzon ◽  
Y. Shafran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Detection ◽  
Hamming Distance ◽  
Formal Model ◽  
Methodological Approach ◽  
Breast Cancer Detection ◽  
Receptor Expression ◽  
Diagnostic Model ◽  
Model Parameters ◽  
Two Stages

Summary Objectives: Formal diagnostic modeling is an important line of modern biological and medical research. The construction of a formal diagnostic model consists of two stages: first, the estimation of correlation between model parameters and the disease under consideration; and second, the construction of a diagnostic decision rule using these correlation estimates. A serious drawback of current diagnostic models is the absence of a unified mathematical methodological approach to implementing these two stages. The absence of aunified approach makesthe theoretical/biomedical substantiation of diagnostic rules difficult and reduces the efficacyofactual diagnostic model application. Methods: The present study constructs a formal model for breast cancer detection. The diagnostic model is based on information theory. Normalized mutual information is chosen as the measure of relevance between parameters and the patterns studied. The “nearest neighbor” rule is utilized for diagnosis, while the distance between elements is the weighted Hamming distance. The model concomitantly employs cellular fluorescence polarization as the quantitative input parameter and cell receptor expression as qualitative parameters. Results: Twenty-four healthy individuals and 34 patients (not including the subjects analyzed for the model construction) were tested by the model. Twenty-three healthy subjects and 34 patients were correctly diagnosed. Conclusions: The proposed diagnostic model is an open one,i.e.it can accommodate new additional parameters, which may increase its effectiveness.

A Handbook to Eddic Poetry: Myths and Legends of Early Scandinavia, ed. Carolyne Larrington, Judy Quinn, and Brittany Schorn. Cambridge: Cambridge University Press, 2016, xii, 413 pp., 12 b/w ill.

Mediaevistik ◽  
2018 ◽  
Vol 31 (1) ◽  
pp. 366-366
Author(s):  
Albrecht Classen
Keyword(s):  
Old Norse ◽  
Entire Volume ◽  
Cambridge University ◽  
Critical Studies ◽  
Individual Contributions ◽  
The Many ◽  
The Individual ◽  
Made In ◽  
Scandinavian Literature

Eddic poetry constitutes one of the most important genres in Old Norse or Scandinavian literature and has been studied since the earliest time of modern-day philology. The progress we have made in that field is impressive, considering the many excellent editions and translations, not to mention the countless critical studies in monographs and articles. Nevertheless, there is always a great need to revisit, to summarize, to review, and to digest the knowledge gained so far. The present handbook intends to address all those goals and does so, to spell it out right away, exceedingly well. But in contrast to traditional concepts, the individual contributions constitute fully developed critical article, each with a specialized topic elucidating it as comprehensively as possible, and concluding with a section of notes. Those are kept very brief, but the volume rounds it all off with an inclusive, comprehensive bibliography. And there is also a very useful index at the end. At the beginning, we find, following the table of contents, a list of the contributors, unfortunately without emails, a list of translations and abbreviations of the titles of Eddic poems in the Codex Regius and then elsewhere, and a very insightful and pleasant introduction by Carolyne Larrington. She briefly introduces the genre and then summarizes the essential points made by the individual authors. The entire volume is based on the Eddic Network established by the three editors in 2012, and on two workshops held at St. John’s College, Oxford in 2013 and 2014.

The Chemical Effect in Medicine Interaction Determining the Form and Speed of Psychical Involution in the Prosthetic Restauration in the Edentulous

2018 ◽  
Vol 69 (8) ◽  
pp. 2306-2310
Author(s):  
Aureliana Caraiane ◽  
Razvan Leata ◽  
Veronica Toba ◽  
Doina Vesa ◽  
Luana Andreea Macovei ◽  
...  
Keyword(s):  
Practical Importance ◽  
Psychosocial Problems ◽  
Well Being ◽  
The Elderly ◽  
Chemical Effect ◽  
Special Importance ◽  
Dramatic Form ◽  
Specific Disorders ◽  
The Individual ◽  
Made In

The progress made in dentistry during the latest decades is due, conceptually, to the new, systemic vision of man, which has also taken place in this field of medicine. In this context, the link between organic and psychic is indestructible. Thus illness is understood as a drama in which the somatic process has a psychic value, and the mental one has a body value. It is known that the morphological and functional integrity of the dental system, health and vigorousness, gives the individual a state of well-being that affects his somatic and psychic health, as any disturbance at this level entails repercussions in psychological and social behavior. Such a disruption is the total edification that seriously alters not only the dental system but the whole organism, putting various biological and psychosocial problems to the practitioner. The total expression represents not only a physical disability but also a psychological one. A special importance in studying psychological changes at total edentulous presents the psychological aspects of senile involution. This is not only a theoretical but also a practical importance due to the increase in the number of elderly people. Through the researches of the present paper we intend to present the reality of the psychological manifestations in the total edentation, which is objectified on different methods of psychodiagnosis in the first part, in order for the second part to be addressed to problems of prosthetic psychotherapy.The study comprises a group of 43 patients, of whom 24 were men and 19 women with total uni or bimaxilar edentation. Total edentation can be and is responsible for somatopsychic alterations, along with other pathogens, general, local, social, which sometimes can take a dramatic form, converting, where the area is also favorable, a pure somatic disease, for those who are not in psychopathy or even psychosis, although these latter cases are extremely rare and especially in youngsters, which would disrupt not only the person�s behavior as an individual, but also their status, function and social integrity. The treatment of dental and psychological complex is mandatory for any patient, but especially for the elderly, where recovery is more difficult, with disease-specific disorders adding to those of senescence.

scholarly journals Combined Luteolin and Indole-3-Carbinol Synergistically Constrains ERα-Positive Breast Cancer by Dual Inhibiting Estrogen Receptor Alpha and Cyclin-Dependent Kinase 4/6 Pathway in Cultured Cells and Xenograft Mice

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2116
Author(s):  
Xiaoyong Wang ◽  
Lijuan Zhang ◽  
Qi Dai ◽  
Hongzong Si ◽  
Longyun Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cell ◽  
Breast Cancer Cells ◽  
Cultured Cells ◽  
Inhibitory Effect ◽  
Cyclin Dependent Kinase ◽  
Xenograft Mice ◽  
The Individual

The high concentrations of individual phytochemicals in vitro studies cannot be physiologically achieved in humans. Our solution for this concentration gap between in vitro and human studies is to combine two or more phytochemicals. We screened 12 phytochemicals by pairwise combining two compounds at a low level to select combinations exerting the synergistic inhibitory effect of breast cancer cell proliferation. A novel combination of luteolin at 30 μM (LUT30) and indole-3-carbinol 40 μM (I3C40) identified that this combination (L30I40) synergistically constrains ERα+ breast cancer cell (MCF7 and T47D) proliferation only, but not triple-negative breast cancer cells. At the same time, the individual LUT30 and I3C40 do not have this anti-proliferative effect in ERα+ breast cancer cells. Moreover, this combination L30I40 does not have toxicity on endothelial cells compared to the current commercial drugs. Similarly, the combination of LUT and I3C (LUT10 mg + I3C10 mg/kg/day) (IP injection) synergistically suppresses tumor growth in MCF7 cells-derived xenograft mice, but the individual LUT (10 mg/kg/day) and I3C (20 mg/kg/day) do not show an inhibitory effect. This combination synergistically downregulates two major therapeutic targets ERα and cyclin dependent kinase (CDK) 4/6/retinoblastoma (Rb) pathway, both in cultured cells and xenograft tumors. These results provide a solid foundation that a combination of LUT and I3C may be a practical approach to treat ERα+ breast cancer cells after clinical trials.

scholarly journals Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2978
Author(s):  
Chia-Jung Li ◽  
Yen-Dun Tony Tzeng ◽  
Yi-Han Chiu ◽  
Hung-Yu Lin ◽  
Ming-Feng Hou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
High Efficiency ◽  
Early Recurrence ◽  
New Developments ◽  
Great Progress ◽  
Low Toxicity ◽  
Made In

Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.

scholarly journals Proteomic Analysis of Zeb1 Interactome in Breast Carcinoma Cells

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3143
Author(s):  
Sergey E. Parfenyev ◽  
Sergey V. Shabelnikov ◽  
Danila Y. Pozdnyakov ◽  
Olga O. Gnedina ◽  
Leonid S. Adonin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Critical Role ◽  
Malignant Neoplasm ◽  
Malignant Neoplasms ◽  
Breast Cancer Patients ◽  
Survival Prognosis ◽  
Mesenchymal Transition ◽  
Wide Range

Breast cancer is the most frequently diagnosed malignant neoplasm and the second leading cause of cancer death among women. Epithelial-to-mesenchymal Transition (EMT) plays a critical role in the organism development, providing cell migration and tissue formation. However, its erroneous activation in malignancies can serve as the basis for the dissemination of cancer cells and metastasis. The Zeb1 transcription factor, which regulates the EMT activation, has been shown to play an essential role in malignant transformation. This factor is involved in many signaling pathways that influence a wide range of cellular functions via interacting with many proteins that affect its transcriptional functions. Importantly, the interactome of Zeb1 depends on the cellular context. Here, using the inducible expression of Zeb1 in epithelial breast cancer cells, we identified a substantial list of novel potential Zeb1 interaction partners, including proteins involved in the formation of malignant neoplasms, such as ATP-dependent RNA helicase DDX17and a component of the NURD repressor complex, CTBP2. We confirmed the presence of the selected interactors by immunoblotting with specific antibodies. Further, we demonstrated that co-expression of Zeb1 and CTBP2 in breast cancer patients correlated with the poor survival prognosis, thus signifying the functionality of the Zeb1–CTBP2 interaction.

scholarly journals Considerations for the Management of Women with Breast Cancer during the COVID-19 Pandemic

2020 ◽  
Vol 5 (03) ◽  
pp. 260-263
Author(s):  
Monica Irukulla ◽  
Palwai Vinitha Reddy
Keyword(s):  
Breast Cancer ◽  
Resource Allocation ◽  
Patient Care ◽  
Cancer Patients ◽  
Cancer Care ◽  
Clinical Care ◽  
Current Availability ◽  
The Individual

AbstractOutcomes in cancer patients are strongly influenced by timeliness and quality of multidisciplinary interventions. The COVID-19 pandemic has led to severe disruption in cancer care in many countries. This has necessitated several changes in clinical care and workflow, including resource allocation, team segregation and deferment of many elective procedures. Several international oncological societies have proposed guidelines for the care of patients afflicted with breast cancer during the pandemic with a view to optimize resource allocation and maximize risk versus benefit for the individual and society. Clinicians may utilize these recommendations to adapt patient care, based on the current availability of resources and severity of the COVID-19 pandemic in each region. This article discusses the guidelines for care of patients afflicted with breast cancer during the pandemic.

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