scholarly journals Bleeding breast mass in a prepubertal child: Benign or malignant? An unusual case of bleeding juvenile fibroadenoma

2017 ◽  
Vol 3 (3) ◽  
pp. 19
Author(s):  
Johann Paulo S. Guzman ◽  
Leandro L. Resurreccion ◽  
Marcus Lester R. Suntay ◽  
Alvin B. Caballes
Keyword(s):  
Unusual Case ◽  
Malignant Tumors ◽  
Pediatric Population ◽  
Breast Mass ◽  
Benign Condition ◽  
Pediatric Age Group ◽  
Clinical Presentations ◽  
Giant Fibroadenoma ◽  
Benign Nature ◽  
Malignant Condition

Malignancy is often suspected in a rapidly growing bleeding breast mass. In the pediatric population, where the majority of tumors are benign, these masses can have clinical presentations that mimic malignant tumors. This is a case of an eleven year old prepubertal female with a huge bleeding breast mass who underwent mastectomy with final histopathology showing giant fibroadenoma. The patient and her relatives were reassured of the benign nature of her disease. We report an uncommon benign condition in children which can be mistaken for a malignant condition often seen in adults. We also present a review on different breast conditions in the pediatric age group and its management.

scholarly journals The Epidemiology of Primary Central Nervous System Tumors at the National Neurologic Institute in Saudi Arabia: A Ten-Year Single-Institution Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Amna Almutrafi ◽  
Yara Bashawry ◽  
Wafaa AlShakweer ◽  
Musa Al-Harbi ◽  
Abdullah Altwairgi ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Malignant Tumors ◽  
Pediatric Population ◽  
Adult Population ◽  
Cns Tumors ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group ◽  
Tumor Entity ◽  
Single Tumor

Objectives. This study is aimed at describing the epidemiological trends of primary CNS tumors in children and adults at the National Neurologic Institute in Saudi Arabia. Methods. A retrospective epidemiological approach was used where data was obtained from the department of pathology registry files and pathology reports. The records of all patients registered from January 2005 to December 2014 with a diagnosis of primary CNS tumor (brain and spinal cord) were selected. Data about sex, age, tumor location, and histologic type were collected. The classification was based on the International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3). Results. Nine hundred and ninety-two (992) cases of primary CNS tumors throughout the ten years (2005 to 2014) were reviewed. There were 714 (71.97%) adults and 278 (28.02%) in the pediatric age group. Nonmalignant tumors dominated the adult population (60.08%) while malignant tumors were more frequent in the pediatric population. Gliomas constituted the most common neoplastic category in children and adults. The most common single tumor entity was meningioma (26.99%, ICD-O-3 histology codes 9530/0, 9539/1, and 9530/3). Medulloblastomas (ICD-O-3 histology codes 9470, 9471, and 9474) were the most common single tumor entity in the pediatric age group (26.62%). Conclusions. This is an institution-based, detailed, and descriptive epidemiological study of patients with primary CNS tumors in Saudi Arabia. In contrast to other regional and international studies, the medulloblastomas in our institution are more frequent than pilocytic astrocytomas. Limitations to our study included the referral bias and histology-based methodology.

Primary stromal sarcoma of breast: A case report and literature review

2021 ◽  
pp. 1-7
Author(s):  
Mohammad Al-Wiswasy ◽  
Mahmoud Al-Balas ◽  
Raith Al-Saffar ◽  
Hamzeh Al-Balas
Keyword(s):  
Malignant Tumors ◽  
Histopathological Examination ◽  
Prognostic Significance ◽  
Total Duration ◽  
Young Patients ◽  
Soft Tissue Sarcomas ◽  
Breast Mass ◽  
Resection Margins ◽  
Stromal Sarcoma ◽  
First Case

INTRODUCTION: Primary breast sarcoma (PBS) was first described in 1887 as a rare heterogeneous neoplasm arising from the mesenchymal tissue of the mammary gland accounting for less than 5% of all body soft-tissue sarcomas and less than 0.1% of all malignant tumors of the breast. CASE PRESENTATION: A 31-year old lady presented with left breast mass which she felt four years before during which the mass increased in size from 1 to 6 cm in the largest diameter, diagnosed clinically as a benign fibroadenoma without any further cytological or histopathological confirmation. Histopathological examination of the excised breast mass reveals undifferentiated, primary stromal sarcoma of the breast (PSSB), which was followed by mastectomy three weeks later with reconstructive breast surgery with a total duration of follow-up of 3 years thereafter. This is the first case of PSSB reported in Jordan. DISCUSSION/CONCLUSION: PSSB is the generic term given to malignant breast tumors thought to arise from the specialized mesenchymal stroma of the breast but lacking an epithelial component with a phylloides pattern. PSSB is difficult to diagnose preoperatively due to its rarity and inadequate imaging methods to establish an exact diagnosis. The histology of the patient mass may be the leading factor for the management of these tumors. Even in very young patients, a progressively growing breast mass should alert the clinician to investigate for malignancy and verify the results by biopsy. Surgery with adequate resection margins represents the only potentially curative modality with prognostic significance. Adjuvant chemotherapy and radiotherapy are not very beneficial. The prognosis is dismal for patients with lymph node involvement and the size of the tumor has a lesser bearing on the outcome.

scholarly journals Neurological manifestation of Vitamin D deficiency

2021 ◽  
pp. 430-432
Author(s):  
Saniya Sroa ◽  
Shweta Nair ◽  
Fehmida N ◽  
Amit Vatkar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pediatric Population ◽  
Pseudotumor Cerebri ◽  
Neurological Manifestation ◽  
Age Group ◽  
Pediatric Age Group ◽  
Pressure Headache ◽  
Common Deficiency ◽  
Visual Disturbances

Idiopathic intracranial hypertension, also known as pseudotumor cerebri, is a disorder with raised intracranial pressure, headache, papilledema, visual disturbances with a normal cerebrospinal fluid examination, and normal neuroimaging. It is rare in the pediatric population and may occur as a manifestation of underlying disorders. Vitamin D deficiency is a common deficiency in the pediatric age group. However, neurological manifestations are rare. Here, we present the case of a 5-year-old male child who presented with headache, vomiting, and hypertension; however, the neurological examination was normal but the neuroimaging was suggestive of pseudotumor cerebri. Appropriate investigations were done. The most likely cause of pseudotumor cerebri in this patient was the deficiency of Vitamin D. We have reported this case as pseudotumor cerebri is a rare neurological manifestation of Vitamin D deficiency.

Qualitative Diagnosis of Solid Breast Mass by Blood Flow in Solid Breast Mass

2021 ◽  
Vol 11 (7) ◽  
pp. 1887-1894
Author(s):  
Chen Cheng ◽  
Chunhong Hu ◽  
Shengli Zhou ◽  
Hongyan Zhao ◽  
Ming Yu
Keyword(s):  
Breast Cancer ◽  
Blood Flow ◽  
High Speed ◽  
Malignant Tumors ◽  
Resistance Index ◽  
The Body ◽  
Breast Mass ◽  
Physical And Mental Health ◽  
Clinical Value ◽  
Hemodynamic Information

Breast cancer is one of the most common malignant tumors that seriously endangers women’s physical and mental health and even life-threatening. With the increasing incidence of breast malignant tumors year by year, people are increasingly concerned about the health of female breasts. However, due to the lack of primary prevention methods for breast cancer, the key to improving the cure rate of breast cancer and reducing mortality is early detection, early diagnosis, and early treatment. Hemodynamics embodies the characteristics and laws of the movement of blood and its components in the body. Clinically, monitoring of hemodynamic indicators is usually used to reveal the physiological or pathological changes of the body and understand the development process of the disease. The blood flow in the tumor tissue is high-speed and high-impedance. CDFI can show the distribution of blood flow in the mass. The highest peak velocity (PSV), resistance index (RI) and pulsatility index (PI) of systolic phase can be measured by sampling. This study use contrast-enhanced ultrasound (CEUS) combined with color energy Doppler flow imaging (CDFI) to explore the hemodynamic information of the main blood supply arteries and masses of the breast, analyze the abnormal hemodynamic information of tumors and surrounding tissues, and explore the blood in the breast, the clinical value of hydrodynamics in the qualitative diagnosis of breast masses.

scholarly journals Intradural Lipoma at the Craniocervical Junction Presenting with Progressing Hemiparesis: A Case Report

2019 ◽  
Vol 11 (2) ◽  
pp. 183-188
Author(s):  
Takuro Inoue ◽  
Hisao Hirai ◽  
Ayako Shima ◽  
Fumio Suzuki ◽  
Masayuki Matsuda ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Pediatric Population ◽  
Adult Population ◽  
Spinal Dysraphism ◽  
Craniocervical Junction ◽  
Suboccipital Craniotomy ◽  
Benign Nature ◽  
Intradural Lipoma ◽  
Radiological Studies ◽  
Dorsal Medulla

Intradural spinal lipomas are rare in an adult population. They are mostly asymptomatic and usually associated with spinal dysraphism in a pediatric population. We report a rare case of spinal lipoma without dysraphism and with progressing hemiparesis. A 60-year-old woman had incidental lipoma at the craniocervical junction observed for more than 5 years. Recently, she developed right-sided hemiparesis and sensory disturbance. Radiological studies revealed a large lipoma compressing the dorsal medulla and C1–C2 spinal cord. Standard midline suboccipital craniotomy and C1 laminectomy were performed, and the lipoma was removed subtotally. The lipoma showed severe adhesion to the dorsal medulla and C1 spinal cord; therefore, the excision was limited as internal debulking. Her neurological deficit subsided within 6 months after the decompressive surgery. Considering the benign nature of lipoma, internal decompression is a reasonable management for this lesion.

Isolated Subglottic Scleroma

1996 ◽  
Vol 75 (5) ◽  
pp. 306-308 ◽  
Author(s):  
Gregory N. Postma ◽  
Steven Wawrose ◽  
Thomas A. Tami
Keyword(s):  
Early Diagnosis ◽  
Respiratory Tract ◽  
Lung Disease ◽  
Chronic Granulomatous Disease ◽  
Chronic Lung Disease ◽  
Unusual Case ◽  
Treatment Modalities ◽  
Granulomatous Disease ◽  
Late Sequelae ◽  
Clinical Presentations

Scleroma, more commonly known as rhinoscleroma, is a progressive, chronic, granulomatous disease of the respiratory tract and adjacent tissues. Early diagnosis and prolonged therapy are critical in avoiding its late sequelae. We describe an unusual case of scleroma presenting as worsening chronic lung disease. The variety of clinical presentations and treatment modalities is reviewed.

Neonatal Campylobacter Fetus Meningitis: A Report of an Unusual Case

1992 ◽  
Vol 31 (4) ◽  
pp. 255-256 ◽  
Author(s):  
William T. Bingham ◽  
Anthony Chan ◽  
Robert Rennie ◽  
Kurt E. Williams ◽  
Koravangattu Sankaran
Keyword(s):  
High Risk ◽  
Unusual Case ◽  
Clinical Presentation ◽  
Neonatal Meningitis ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group ◽  
Campylobacter Fetus

Campylobacter fetus is a rare cause of meningitis in the pediatric age group and, in particular, among neonates. The clinical presentation of campylobacter meningitis in high-risk neonates is not well-described. A review of campylobacter meningitis by Lee et al1 in 1985 reported nine cases occurring in neonates, of which only one case was caused by C. fetus. In the ensuing six years only three more confirmed cases of neonatal meningitis caused by C. fetus have been reported.2,3 We here report another confirmed case of C. fetus meningitis in a neonate.

Plasma Cell Gingivitis Among Herbal Toothpaste Users: A Report of Three Cases

2007 ◽  
Vol 8 (4) ◽  
pp. 60-66 ◽  
Author(s):  
Sukumaran Anil
Keyword(s):  
Plasma Cell ◽  
Plasma Cells ◽  
Hypersensitive Reaction ◽  
Herbal Products ◽  
Benign Condition ◽  
Patients Âgés ◽  
Clinical Presentations ◽  
Attached Gingiva ◽  
History Of ◽  
Collagenous Stroma

Abstract Aim The aim of this article is to present a brief review of plasma cell gingivitis (PCG) along with reports of three cases with varying clinical presentations of the condition associated with the use of herbal toothpaste. Background PCG is a rare benign condition of the gingiva characterized by sharply demarcated erythematous and edematous gingivitis often extending to the mucogingival junction. This is considered a hypersensitive reaction. The histological appearance consists of a dense infiltration of normal plasma cells separated by collagenous stroma, usually confined to the free and attached gingiva. The lesion can be eliminated by identifying and avoiding the source of the allergen. Report Three patients ages 26, 27, and 36, respectively, presented with acutely inflamed gingival and a history of recently switching to herbal toothpaste. The gingiva bled readily on probing. Blood tests and gingival biopsy were not contributory. Patients were advised to refrain from the use of herbal toothpaste, and, along with periodontal treatment, the condition underwent remission within a week to two weeks in all three cases. Summary As more and more herbal products are gaining popularity, clinicians should be aware of some of the untoward effects of these products. Since PCG mimics lesions associated with leukemia and myeloma an early diagnosis of the condition is vital. Citation Anil S. Plasma Cell Gingivitis Among Herbal Toothpaste Users: A Report of Three Cases. J Contemp Dent Pract 2007 May;(8)4:060-066.

Preliminary data of a phase I-II clinical and pharmacokinetic study of plitidepsin in children with malignant tumors. On behalf of the European ITCC (Innovative Therapies for Children with Cancer) Consortium

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 9060-9060
Author(s):  
B. Geoerger ◽  
F. Doz ◽  
E. Estlin ◽  
P. Kearns ◽  
J. Lopez-Martin ◽  
...  
Keyword(s):  
Side Effects ◽  
Phase I ◽  
Solid Tumors ◽  
Half Life ◽  
Malignant Tumors ◽  
Pediatric Population ◽  
Dose Finding ◽  
Hematological Toxicity ◽  
Pharmacokinetic Data ◽  
Open Label

9060 Background: Plitidepsin (Aplidin) is a cyclic depsipeptide isolated from the tunicate Aplidium albicans, nowadays manufactured by synthesis. It is a rapid and potent inductor of apoptosis. Phase I trials in adults explored 5 different schedules. Muscle and liver toxicities were dose-limiting; hematological toxicity was not observed at the recommended dose (RD). Methods: This is a multicentre, open-label, non-randomized phase I-II study with a dose finding stage in children with solid tumors, and two expanded cohorts in leukemia and solid tumors at the RD. Plitidepsin was administered as a 3 h iv infusion every 2 weeks (=1 cycle). The initial dose level was 4 mg/m2 (80% of the RD in adults), with a classical escalation to 5 and 6 mg/m2. Results: 16 patients have been entered to date with median age 7.5 years (range 2–17). 54 cycles in 15 patients were evaluable for toxicity. 8 patients were treated at 4 mg/m2, five at 5 mg/m2 and three at 6 mg/m2. One patient presented dose-limiting G2 myalgia lasting more than 2 weeks at 4mg/m2. The Maximum Tolerated Dose (MTD) has not been reached at 6 mg/m2. Non-hematological toxicities included G1-G2 muscle side effects: (myalgia, CPK elevation, muscle weakness), G1–2 fatigue, G3 vomiting. One G3 hypersensitivity reaction was observed without prophylactic treatment. Pharmacokinetic data are similar to those reported in adult (extensive tissue distribution, a long half-life); if any, clearance was slightly higher and half-life shorter. Partial response was observed in a pancreatoblastoma and disease stabilization in a progressive medulloblastoma. Conclusions: Plitidepsin was well tolerated in children, with muscular side effects being the most relevant toxicity observed. The MTD for the pediatric population has not yet been achieved at a dose 1.2 fold above the RD in adults. [Table: see text]

Staged bilateral far-lateral approach for bilateral cervicomedullary junction neurenteric cysts in a 10-year-old girl

2013 ◽  
Vol 12 (3) ◽  
pp. 274-280 ◽  
Author(s):  
Smruti K. Patel ◽  
James K. Liu
Keyword(s):  
Unusual Case ◽  
Pediatric Population ◽  
Craniocervical Junction ◽  
Lateral Approach ◽  
Rare Occurrence ◽  
Benign Lesions ◽  
Far Lateral Approach ◽  
The Central Nervous System ◽  
Far Lateral ◽  
Pontomedullary Junction

Neurenteric cysts are rare and benign lesions that consist of ectopic alimentary tissue residing in the central nervous system. They tend to occur most frequently in an intraspinal rather than intracranial location. Intracranial neurenteric cysts are a rare occurrence in the pediatric population. These lesions typically present as unilateral cystic structures in the lower cerebellopontine angle and craniocervical junction. To the authors' knowledge, there have been no reported cases of bilateral localization of intracranial neurenteric cysts. In this report, they present an unusual case of a 10-year-old girl who was found to have bilateral intracranial neurenteric cysts at the pontomedullary junction. The patient was successfully treated with staged, bilateral far-lateral transcondylar resection of the cysts. The authors also provide a brief overview of the literature describing intracranial neurenteric cysts in children.

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