scholarly journals Impact of motion correction on the quantitative analysis of DCE-MR Images

2005 ◽  
Author(s):  
Kishore Mosaliganti ◽  
Guang Jia ◽  
Johannes Heverhagen ◽  
raghu machiraju ◽  
Joel Saltz ◽  
...  
Keyword(s):  
Contrast Media ◽  
Motion Correction ◽  
Quantitative Estimation ◽  
Region Of Interest ◽  
Compartment Model ◽  
Non Invasive ◽  
Trade Offs ◽  
Two Compartment Model ◽  
Matching Procedure ◽  
Malignant Lesions

Dynamic magnetic resonance imaging (DCE-MRI) carried out with contrast media such as Gd-chelate complex (Gd-DTPA) allows the non-invasive assessment of microcirculatory characteristics of malignant lesions. Quantitative estimation of lesion parameters from the passage of the contrast media requires the use of pharmacokinetic two-compartment model. The input to the model is the time-intensity plot from a region of interest (ROI) covering the lesion extent. The lengthy imaging process, elasticity of the organs and patient movement result in complex deformations in the subject requiring 3D motion correction for ROI alignment. This paper presents results on applying the Thirion Demon’s 3D elastic matching procedure in the ITK framework on the two-compartment lesion parameters. Registration, meanwhile involves interpolation and smoothing operations thereby affecting the time-intensity plots. We explore the trade-offs that arise between registration and lesion parameter estimation. Experiments on synthesized and real deformation are presented.

Clearance and Non-Invasive Determination of the Hepatic Extraction of Indocyanine Green in Baboons and Man

1983 ◽  
Vol 64 (2) ◽  
pp. 207-212 ◽  
Author(s):  
S. L. Grainger ◽  
P. W. N. Keeling ◽  
I. M. H. Brown ◽  
J. H. Marigold ◽  
R. P. H. Thompson
Keyword(s):  
Indocyanine Green ◽  
Accurate Determination ◽  
Liver Blood Flow ◽  
Compartment Model ◽  
Hepatic Extraction ◽  
Non Invasive ◽  
Two Compartment Model ◽  
Hepatic Extraction Ratio ◽  
Plasma Disappearance Curve

1. The disposition of an intravenous bolus of indocyanine green (ICG) has been studied in healthy man and baboons using a novel analysis of a two compartment pharmacokinetic model. 2. This analysis enabled the hepatic extraction ratio (ER) of dye to be determined solely from the plasma disappearance curve, and the ER determined did not differ from that measured by hepatic vein catheterization. 3. When compared with clearance measured at steady state, the two compartment model gave a significantly more accurate determination of plasma clearance than did the conventional one compartment model. 4. It is concluded that, in health, liver blood flow may be calculated accurately and noninvasively after a single intravenous injection of ICG.

Low VA/Q areas: arterial-alveolar N2 difference and multiple inert gas elimination technique

1988 ◽  
Vol 64 (5) ◽  
pp. 2224-2229 ◽  
Author(s):  
P. Radermacher ◽  
R. Herigault ◽  
B. Teisseire ◽  
A. Harf ◽  
F. Lemaire
Keyword(s):  
Quantitative Estimation ◽  
Venous Blood ◽  
Compartment Model ◽  
Inert Gas ◽  
Mixed Venous Blood ◽  
Perfusion Fraction ◽  
Two Compartment Model ◽  
Close Relationship ◽  
The Difference ◽  
Ventilation Perfusion Ratio

In 16 critically ill patients the arterial-alveolar N2 difference and data from the multiple inert gas elimination technique (MIGET) were compared in the evaluation of the contribution of low alveolar ventilation-perfusion ratio (VA/Q) lung regions (0.005 less than VA/Q less than 0.1) to venous admixture (Qva/QT). The arterial-alveolar N2 difference was determined using a manometric technique for the measurement of the arterial N2 partial pressure (PN2). We adopted a two-compartment model of the lung, one compartment having a VA/Q of approximately 1, the other being open, gas filled, unventilated (VA/Q = 0), and in equilibrium with the mixed venous blood. This theoretical single compartment represents all lung regions responsible for the arterial-alveolar N2 difference. The fractional blood flow to this compartment was calculated using an appropriate mixing equation (Q0/QT). There was a weak but significant relationship between Q0/QT and the perfusion fraction to lung regions with low VA/Q (0.005 less than VA/Q less than 0.1) (r = 0.542, P less than 0.05) and a close relationship between Q0/QT and the perfusion fraction to lung regions with VA/Q ratios less than 0.9 (r = 0.862, P less than 0.001) as obtained from MIGET. The difference Qva/QT-Q0/QT yielded a close estimation of the MIGET right-to-left shunt (Qs/QT) (r = 0.962, P less than 0.001). We conclude that the assessment of the arterial-alveolar N2 difference and Q0/QT does not yield a quantitative estimation of the contribution of pathologically low VA/Q areas to QVa/QT because these parameters reflect an unknown combination of pathological and normal (0.1 less than VA/Q less than 0.9) gas exchange units.(ABSTRACT TRUNCATED AT 250 WORDS)

Experimental Validation of Minimax Entropy Principle in Ultrasound Images

2019 ◽  
Vol 12 (6) ◽  
pp. 487-493
Author(s):  
Neha Mehta ◽  
Svav Prasad ◽  
Leena Arya
Keyword(s):  
Region Of Interest ◽  
Ultrasound Images ◽  
Human Gallbladder ◽  
New Approach ◽  
Non Invasive ◽  
Entropy Principle ◽  
Significant Performance ◽  
Considerable Impact ◽  
Ultrasonic Devices ◽  
Measure Of Uncertainty

Ultrasound imaging is one of the non-invasive imaging, that diagnoses the disease inside a human body and there are numerous ultrasonic devices being used frequently. Entropy as a well known statistical measure of uncertainty has a considerable impact on the medical images. A procedure for minimizing the entropy with respect to the region of interest is demonstrated. This new approach has shown the experiments using Extracted Region Of Interest Based Sharpened image, called as (EROIS) image based on Minimax entropy principle and various filters. In this turn, the approach also validates the versatility of the entropy concept. Experiments have been performed practically on the real-time ultrasound images collected from ultrasound centers and have shown a significant performance. The present approach has been validated with showing results over ultrasound images of the Human Gallbladder.

scholarly journals Microwave thermometry with potential application in non-invasive monitoring of hyperthermia

2020 ◽  
Vol 28 (5) ◽  
pp. 739-750
Author(s):  
Morteza Ghaderi Aram ◽  
Larisa Beilina ◽  
Hana Dobsicek Trefna
Keyword(s):  
Least Squares Method ◽  
Regularization Parameter ◽  
Region Of Interest ◽  
Optimal Choice ◽  
Adaptive Finite Element Method ◽  
Adaptive Finite Element ◽  
Non Invasive ◽  
Full Wave ◽  
Reconstruction Quality ◽  
Regularization Techniques

AbstractIntegration of an adaptive finite element method (AFEM) with a conventional least squares method has been presented. As a 3D full-wave forward solver, CST Microwave Studio has been used to model and extract both electric field distribution in the region of interest (ROI) and S-parameters of a circular array consisting of 16 monopole antennas. The data has then been fed into a differential inversion scheme to get a qualitative indicator of how the temperature distribution evolves over a course of the cooling process of a heated object. Different regularization techniques within the Tikhonov framework are also discussed, and a balancing principle for optimal choice of the regularization parameter was used to improve the image reconstruction quality of every 2D slice of the final image. Targets are successfully imaged via proposed numerical methods.

Two-Compartment Model of Cholesterol Kinetics for Establishment of Treatment Strategy of LDL Apheresis in Nephrotic Hypercholesterolemia

1994 ◽  
Vol 12 (6) ◽  
pp. 317-326 ◽  
Author(s):  
Masatomo Yashiro ◽  
Eri Muso ◽  
Munehiro Matsushima ◽  
Ryoichi Nagura ◽  
Kenji Sawanishi ◽  
...  
Keyword(s):  
Treatment Strategy ◽  
Compartment Model ◽  
Ldl Apheresis ◽  
Two Compartment Model

MO226A NEW DIAGNOSTIC TOOL FOR CKD PATIENTS: CONTRAST-ENHANCED ULTRASONOGRAPHY. A SINGLE CENTER EXPERIENCE

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Mirela Liana Gliga ◽  
Cristian Chirila ◽  
Paula Chirila ◽  
Adriana Gomotarceanu ◽  
Imola Torok ◽  
...  
Keyword(s):  
Diagnostic Tool ◽  
Final Diagnosis ◽  
Medical System ◽  
Focal Lesions ◽  
Non Invasive ◽  
Single Center Experience ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography ◽  
Malignant Lesions ◽  
Guidelines And Recommendations

Abstract Background and Aims Contrast-enhanced ultrasonography (CEUS) is a minimally invasive diagnostic tool available for diagnosing microvascular disturbances in tumors and many vascular pathologies. Unlike other radiological contrast agents, it is completely harmless for CKD patients and therefore it is used for the safe diagnosis of many diffuse or focal pathologies. Method We used CEUS examination in 50 CKD patients for the following pathologies: 10 atypical cysts, 15 liver focal lesions, 2 splenic focal lesions, 3 renal infarcts, 12 kidney focal lesions and 8 other organ involvements. Examination was made using a VOLUSON E8 machine (GE Medical System Kreztechnik GmbH Tiefenbach 15, Austria) with a 3.5 MHz convex array abdominal transducer. 2.4 ml of microbubble contrast-agent was administered intravenously and recording of the results were made for 3-5 minutes after injection. Results Depending on the organ vascular characteristics, contrast enhancement and/or wash-out were suggestive for the final diagnosis. In liver lesions there are three phases and in kidneys, spleen, gallbladder, adenopathies there are two vascular phases. We obtained a very good positive predictive value and sensitivity in detecting malignant lesions. Conclusion According to The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound they are used both for hepatic and Non-Hepatic Applications. Being non-invasive and non-irradiating it could be the main diagnostic examination in CKD population in the future.

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