scholarly journals A Treatment Planning System for the Small Animal Radiation Research Platform (SARRP) based on 3D Slicer

2012 ◽  
Author(s):  
Nathan Cho ◽  
Peter Kazanzides
Keyword(s):  
Treatment Planning ◽  
High Performance ◽  
Treatment Plan ◽  
Small Animal ◽  
Planning System ◽  
Treatment Planning System ◽  
3D Slicer ◽  
Research Platform ◽  
Typical Treatment ◽  
Radiation Research

This paper describes the software integration of a treatment planning system (TPS), based on the open-source 3D Slicer package, with the Small Animal Radiation Research Platform (SARRP).The TPS is designed to enable researchers to replicate their clinical techniques, allow for image fusion with other imaging modalities, and provide dose computation and graphical visualization of treatment plans consisting of multiple x-ray beams and conformable arcs. The dose computation is implemented on a GPU to achieve high performance; the dose volume for a typical treatment plan can be computed in less than a minute.

scholarly journals Dose Painting with a Variable Collimator for the Small Animal Radiation Research Platform (SARRP)

2014 ◽  
Author(s):  
Nathan Cho ◽  
John Wong ◽  
Peter Kazanzides
Keyword(s):  
Radiation Treatment ◽  
Small Animal ◽  
Planning System ◽  
Treatment Planning System ◽  
Target Area ◽  
Dose Painting ◽  
Target Region ◽  
Research Platform ◽  
Minimum Number ◽  
Radiation Research

The goal of radiation treatment is to irradiate cancer cells (i.e., a target region) without destroying adjacent healthy tissue. Thus, it is advantageous to form the beam so that it best approximates the target, thereby reducing the amount of dose absorbed in critical regions outside the target area. While multi-leaf collimators are common in human clinical systems, small animal radiotherapy systems are typically limited to a set of fixed-size collimators. For these systems, dose painting can be used for conformal dose delivery, but is significantly slower than a multi-leaf collimator. As a compromise solution, a variable rectangular collimator has been developed for the Small Animal Radiation Research Platform (SARRP). This enables more efficient dose painting via the decomposition of a 2D target region into a minimum number of rectangles of variable size, which is the topic of this paper. The proposed method consists of several distinct steps and was implemented on the SARRP Treatment Planning System (TPS).

Utilising virtual bolus in superficial planning target volume dose optimisation (TomoTherapy): a phantom study

2019 ◽  
Vol 19 (1) ◽  
pp. 65-70
Author(s):  
Gim Chee Ooi ◽  
Iskandar Shahrim Bin Mustafa
Keyword(s):  
Treatment Planning ◽  
Planning Target Volume ◽  
Treatment Plan ◽  
Target Volume ◽  
The Body ◽  
Phantom Study ◽  
Planning System ◽  
Treatment Planning System ◽  
Dose Volume Histograms ◽  
Photon Fluence

AbstractAim:This is a phantom study to evaluate the dosimetry effects of using virtual bolus (VB) in TomoTherapy Treatment Planning System (TPS) optimisation for superficial planning target volume (PTV) that extends to the body surface. Without VB, the inverse-planning TPS will continuously boost the photon fluence at the surface of the superficial PTV due to lack of build-up region. VB is used during TPS optimisation only and will not be present in actual treatment delivery.Materials and methods:In this study, a dummy planning target was contoured on a cylindrical phantom which extends to the phantom surface, and VB of various combinations of thickness and density was used in treatment planning optimisation with TomoTherapy TPS. The plans were then delivered with the treatment modality TomoTherapy. Radiochromic films (Gafchromic EBT3) were calibrated and used for dose profiles measurements. TomoTherapy Planned-Adaptive software was used to analyse the delivered Dose-Volume Histograms (DVHs).Results:The use of 2 mm VB was not providing adequate build-up area and was unable to reduce the hot spots during treatment planning and actual delivery. The use of 4 mm VB was able to negate the photon fluence boosting effect by the TPS, and the actual delivery showed relatively small deviations from the treatment plan. The use of 6 mm VB caused significant dose overestimation by the TPS in the superficial regions resulting in insufficient dose coverage delivered.Findings:VB with the combination of 4 mm thickness and 1·0 g/cc density provides the most robust solution for the TomoTherapy TPS optimisation of superficial PTV.

scholarly journals Evaluation of Delta4DVH Anatomy in 3D Patient-Specific IMRT Quality Assurance

2020 ◽  
Vol 19 ◽  
pp. 153303382094581
Author(s):  
Du Tang ◽  
Zhen Yang ◽  
Xunzhang Dai ◽  
Ying Cao
Keyword(s):  
Quality Assurance ◽  
Treatment Planning ◽  
Treatment Plan ◽  
Planning System ◽  
Treatment Planning System ◽  
Patient Specific ◽  
Pencil Beam ◽  
Ion Chamber ◽  
Passing Rate ◽  
Gamma Passing Rate

Purpose: To evaluate the performance of Delta4DVH Anatomy in patient-specific intensity-modulated radiotherapy quality assurance. Materials and Methods: Dose comparisons were performed between Anatomy doses calculated with treatment plan dose measured modification and pencil beam algorithms, treatment planning system doses, film doses, and ion chamber measured doses in homogeneous and inhomogeneous geometries. The sensitivity of Anatomy doses to machine errors and output calibration errors was also investigated. Results: For a Volumetric Modulated Arc Therapy (VMAT) plan evaluated on the Delta4 geometry, the conventional gamma passing rate was 99.6%. For a water-equivalent slab geometry, good agreements were found between dose profiles in film, treatment planning system, and Anatomy treatment plan dose measured modification and pencil beam calculations. Gamma passing rate for Anatomy treatment plan dose measured modification and pencil beam doses versus treatment planning system doses was 100%. However, gamma passing rate dropped to 97.2% and 96% for treatment plan dose measured modification and pencil beam calculations in inhomogeneous head & neck phantom, respectively. For the 10 patients’ quality assurance plans, good agreements were found between ion chamber measured doses and the planned ones (deviation: 0.09% ± 1.17%). The averaged gamma passing rate for conventional and Anatomy treatment plan dose measured modification and pencil beam gamma analyses in Delta4 geometry was 99.6% ± 0.89%, 98.54% ± 1.60%, and 98.95% ± 1.27%, respectively, higher than averaged gamma passing rate of 97.75% ± 1.23% and 93.04% ± 2.69% for treatment plan dose measured modification and pencil beam in patients’ geometries, respectively. Anatomy treatment plan dose measured modification dose profiles agreed well with those in treatment planning system for both Delta4 and patients’ geometries, while pencil beam doses demonstrated substantial disagreement in patients’ geometries when compared to treatment planning system doses. Both treatment planning system doses are sensitive to multileaf collimator and monitor unit (MU) errors for high and medium dose metrics but not sensitive to the gantry and collimator rotation error smaller than 3°. Conclusions: The new Delta4DVH Anatomy with treatment plan dose measured modification algorithm is a useful tool for the anatomy-based patient-specific quality assurance. Cautions should be taken when using pencil beam algorithm due to its limitations in handling heterogeneity and in high-dose gradient regions.

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