Roles of selenoprotein K and selenium status in the etiopathogenesis of preeclampsia: Their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase

2018 ◽  
Vol 35 (07) ◽  
pp. 124-130
Author(s):  
Fatma Behice Serinkan Cinemre ◽  
Birsen Aydemir ◽  
Tevfik Gulyasar ◽  
Hakan Cinemre ◽  
Abdullah Tuten ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Glutathione Peroxidase ◽  
Oxidative Dna Damage ◽  
Selenium Status ◽  
Selenoprotein K

Acrylamide Exposure and Oxidative DNA Damage, Lipid Peroxidation and Fasting Plasma Glucose Alteration: Association and Mediation Analyses in Chinese Urban Adults

2020 ◽  
Author(s):  
Bin Wang ◽  
Weihong Qiu ◽  
Shijie Yang ◽  
Limin Cao ◽  
Chunmei Zhu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Oxidative Dna Damage ◽  
Adult Population ◽  
Prostaglandin F2α ◽  
Mediation Analyses ◽  
Mediating Role ◽  
Fasting Plasma

<a><b>OBJECTIVE: </b></a>Acrylamide exposure from daily-consumed food has raised global concern.<b> </b>We aimed to assess the exposure-response relationships of internal acrylamide exposure with oxidative DNA damage, lipid peroxidation and fasting plasma glucose (FPG) alteration, and investigate the mediating role of oxidative DNA damage and lipid peroxidation in the association of internal acrylamide exposure with FPG. <p><b>RESEARCH DESIGN AND METHODS:</b> FPG and urinary biomarkers of oxidative DNA damage (8-hydroxy-deoxy-guanosine, 8-OHdG), lipid peroxidation (8-iso-prostaglandin-F2α, 8-iso-PGF2α) and acrylamide exposure (N-acetyl-S-(2-carbamoylethyl)-L-cysteine, AAMA; N-acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine, GAMA) were measured for 3,270 general adults from the Wuhan-Zhuhai cohort. The associations of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG were assessed by linear mixed models. The mediating roles of 8-OHdG and 8-iso-PGF2α were evaluated by mediation analysis.</p> <p><b>RESULTS:</b> We found significant linear positive dose-response relationships of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α and FPG (except GAMA with FPG), and 8-iso-PGF2α with FPG. Each 1-unit increase in log-transformed level of AAMA, ΣUAAM (AAMA+GAMA) or 8-iso-PGF2α was associated with a 0.17-, 0.15- or 0.23-mmol/L increase in FPG, respectively (<i>P </i>or/and<i> P trend</i><0.05). Each 1% increase in AAMA, GAMA or ΣUAAM was associated with a 0.19%, 0.27% or 0.22% increase in 8-OHdG, respectively, and a 0.40%, 0.48% or 0.44% increase in 8-iso-PGF2α, respectively (<i>P </i>and<i> P trend</i><0.05). Increased 8-iso-PGF2α rather than 8-OHdG significantly mediated 64.29% and 76.92% of the AAMA and ΣUAAM associated-FPG increases, respectively.</p> <p><b>CONCLUSIONS:</b> Exposure of general adult population to acrylamide was associated with FPG elevation, oxidative DNA damage and lipid peroxidation, which in turn partly mediated acrylamide-associated FPG elevation.<b></b></p>

scholarly journals Associations between glutathione peroxidase-1 Pro198Leu polymorphism, selenium status, and DNA damage levels in obese women after consumption of Brazil nuts

Nutrition ◽  
2011 ◽  
Vol 27 (9) ◽  
pp. 891-896 ◽  
Author(s):  
Cristiane Cominetti ◽  
Maritsa Carla de Bortoli ◽  
Eduardo Purgatto ◽  
Thomas Prates Ong ◽  
Fernando Salvador Moreno ◽  
...  
Keyword(s):  
Dna Damage ◽  
Glutathione Peroxidase ◽  
Selenium Status ◽  
Obese Women ◽  
Glutathione Peroxidase 1 ◽  
Brazil Nuts

In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases

2002 ◽  
Vol 37 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Shuichi Seki ◽  
Takuya Kitada ◽  
Takao Yamada ◽  
Hiroki Sakaguchi ◽  
Kazuki Nakatani ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Fatty Liver ◽  
Liver Diseases ◽  
Oxidative Dna Damage ◽  
Alcoholic Fatty Liver ◽  
In Situ Detection

Almond consumption reduces oxidative DNA damage and lipid peroxidation in young male smokers

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Xudong Jia ◽  
Chung‐Yen Chen ◽  
Jeffrey B. Blumberg ◽  
Ning Li
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Young Male

The steady-state levels of oxidative DNA damage and of lipid peroxidation (F2-isoprostanes) are not correlated in healthy human subjects

2000 ◽  
Vol 32 (4) ◽  
pp. 355-362 ◽  
Author(s):  
Timothy England ◽  
Emily Beatty ◽  
Almas Rehman ◽  
Jaffar Nourooz-Zadeh ◽  
Paulo Pereira ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Steady State ◽  
Oxidative Dna Damage ◽  
Human Subjects ◽  
Healthy Human ◽  
Healthy Human Subjects ◽  
Steady State Levels

scholarly journals Does lipid peroxidation and oxidative DNA damage differ in cryopreserved semen samples from young, adult and aged Nellore bulls?

2018 ◽  
Vol 195 ◽  
pp. 8-15
Author(s):  
Juliane Teramachi Trevizan ◽  
Janaina Torres Carreira ◽  
Isadora Resende Carvalho ◽  
Bruna Helena Kipper ◽  
Walter Bertequine Nagata ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Young Adult ◽  
Oxidative Dna Damage
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