Comparative assessment of trace metals in the blood of ovary cancer patients and controls

2015 ◽  
Vol 32 (04) ◽  
pp. 65-73
Author(s):  
Muhammad Abdul Qayyum ◽  
Munir H. Shah
Keyword(s):  
Trace Metals ◽  
Cancer Patients ◽  
Comparative Assessment ◽  
Ovary Cancer

scholarly journals TRACE METALS IN CANCER PATIENTS AND THEIR CORRELATION WITH RENAL FUNCTION

2003 ◽  
Vol 42 (146) ◽  
pp. 71-73
Author(s):  
Shankhar Majhi ◽  
B D Toora ◽  
S K Sen ◽  
K Anantha ◽  
N Anantha
Keyword(s):  
Trace Elements ◽  
Trace Metals ◽  
Cancer Patients ◽  
Serum Zinc ◽  
Serum Copper ◽  
The Body ◽  
Significant Elevation ◽  
Super Oxide Dismutase ◽  
Carcinoma Stomach ◽  
Cu And Zn

ABSTRACTTwo trace elements, copper (Cu) and zinc (Zn) in serum are elevated in cancer patients since both areconstituents of super oxide dismutase (SOD) as metalloenzyme, the enzyme that scavenge free radicals andactivated oxygen species in the body. The study of 52 cancer patients comprising of 31 carcinoma stomachand 21 breast cancer showed the elevation of both of these trace elements in serum when compared to 32healthy controls and effected the kidney functions as a consequences. Serum Cu and Zn were estimated byAtomic Absorption Spectrometer (AAS), analyzed statistically by student "t" test and marked elevationwas observed in cancer patient compared to healthy controls. Serum Cu and Zn values were 98.13 ± 17.49μg/dl 99..57 ± 13.91 μg /dl respectively in 38 healthy subjects and these trace metals were 156.23 ± 31.02 μg/dl and 171.86 ± 35.15 μg/dl in 52 cancer patients showing significant elevation (P <0.001). These elevatedelements were routed through kidneys and damaged nephrons since both of them are cationic heavy metals.Nephrotoxicity of these trace metals was reflected as elevated level of blood urea and creatinine and werefound to be 27.44 ± 7.72 mg /dl and 0.83 ± 0.30 mg/dl in control groups and 64.49 ± 49 mg /dl and 1.60 ± 0.72mg/dl in cancer patients respectively, a significant elevation (P<0.001) in study group. The elevation ofthese parameters may indicate renal origin.Key Words: Serum copper, serum zinc, super oxide dismutase, carcinoma stomach, carcinoma breastand nephrotoxicity.

Ovary Cancer Detection using Decision Tree Classifiers based on Historical Data of Ovary Cancer Patients

2017 ◽  
pp. 503-510 ◽  
Author(s):  
Ahmed Osmanović ◽  
Layla Abdel-Ilah ◽  
Adnan Hodžić ◽  
Jasmin Kevric ◽  
Adnan Fojnica
Keyword(s):  
Decision Tree ◽  
Cancer Patients ◽  
Cancer Detection ◽  
Historical Data ◽  
Ovary Cancer

Risk evaluation about genetic screening among ovary cancer with regard to Lynch syndrome.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e13000-e13000
Author(s):  
Min Kyu Kim
Keyword(s):  
Lynch Syndrome ◽  
Cancer Patients ◽  
Risk Evaluation ◽  
Large Population ◽  
Clinical Information ◽  
Cost Effective ◽  
Hereditary Cancer Syndrome ◽  
Cancer Syndrome ◽  
Ovary Cancer ◽  
History Of

e13000 Background: Hereditary cancer syndrome about ovary cancer is mostly BRCA related. But mismatch repair genes related Lynch syndrome is also associated with it.There is not much study about risk evaluation about this among Korean population. We investigate this. Methods: A retrospective review of ovary cancer patients who was counseled about Lynch syndrome in Department of Obstetrics and gynecology, Samsung Changwon Hospital by single surgeon was done. Clinical information was extracted from the medical record including age, family and personal history of cancer, immunohistochemistry (IHC) of MLH1/MSH2, microsatellite instability test (MSI). Results: Total test was 26.mean age was 54(16~75) and fifty percent was serous type (13/26).There were 2 patients with Lynch syndrome related cancer family history (stomach and ovary) among their 1st degree relatives. Only one patient has abnormal MLH1 IHC.There were three unstable MSI patients (BAT26, D2S123, D55346, and NR21). Conclusions: We found three abnormal MSI patients among this population. Cost effective algorithm using multiple genetic testing to find Lynch syndrome associated ovary cancer patients should be developed through large population study.

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