Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO Grade, and patient age

2009 ◽  
Vol 28 (01) ◽  
pp. 21-27 ◽  
Author(s):  
W. Yi ◽  
H. Haapasalo ◽  
C. Holmlund S. Järvelä ◽  
O. Raheem ◽  
A.T. Bergenheim ◽  
...  
Keyword(s):  
Tumor Location ◽  
Patient Age ◽  
Who Grade ◽  
Patient Âgé ◽  
Leucine Rich Repeats

scholarly journals Chart review of diagnostic methods, baseline characteristics and symptoms for European patients with pancreatic cancer

2021 ◽  
Vol 17 (15) ◽  
pp. 1843-1854
Author(s):  
Alfredo Carrato ◽  
Davide Melisi ◽  
Gerald Prager ◽  
Christoph B Westphalen ◽  
Anabel Ferreras ◽  
...  
Keyword(s):  
Chart Review ◽  
Diagnostic Technique ◽  
Tumor Location ◽  
Diagnostic Methods ◽  
Ductal Adenocarcinoma ◽  
Inclusion Criteria ◽  
First Line ◽  
Patient Age ◽  
Patient Âgé ◽  
Baseline Characteristics

Aim: To survey European physicians managing patients with metastatic pancreatic ductal adenocarcinoma (PDAC) and understand differences in baseline characteristics, diagnostic methods, symptoms and co-morbidities. Materials & methods: Patient record inclusion criteria were: ≥18 years old, metastatic PDAC diagnosis and completion of first-line treatment between July 2014 and January 2016. Records were grouped by patient age, gender and primary tumor location. Results: Records (n = 2565) were collected from nine countries. Baseline characteristics varied between subgroups. Computed tomography was the most frequently used diagnostic technique. Symptoms at diagnosis included abdominal and/or mid-back pain (72% of patients) and weight loss (61.5%). Co-morbidities varied with patient age. Conclusion: Greater awareness of symptoms, diagnostic methods and co-morbidities present at PDAC diagnosis may support better patient management decisions.

scholarly journals ACTC1 as an invasion and prognosis marker in glioma

2017 ◽  
Vol 126 (2) ◽  
pp. 467-475 ◽  
Author(s):  
Shunya Ohtaki ◽  
Masahiko Wanibuchi ◽  
Yuko Kataoka-Sasaki ◽  
Masanori Sasaki ◽  
Shinichi Oka ◽  
...  
Keyword(s):  
Hazard Ratio ◽  
Qualitative Assessment ◽  
Surgical Removal ◽  
Negative Group ◽  
Radiological Findings ◽  
Patient Age ◽  
Who Grade ◽  
Positive Group ◽  
Patient Âgé ◽  
Mib 1

OBJECTIVE Glioma is a major class of brain tumors, and glioblastoma (GBM) is the most aggressive and malignant type. The nature of tumor invasion makes surgical removal difficult, which results in remote recurrence. The present study focused on glioma invasion and investigated the expression of actin, alpha cardiac muscle 1 (ACTC1), which is 1 of 6 actin families implicated in cell motility. METHODS mRNA expression of ACTC1 expression was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR) in 47 formalin-fixed, paraffin-embedded glioma tissues that were graded according to WHO criteria: Grade I (n = 4); Grade II (n = 12); Grade III (n = 6); and Grade IV (n = 25). Survival was analyzed using the Kaplan-Meier method. The relationships between ACTC1 expression and clinical features such as radiological findings at the time of diagnosis and recurrence, patient age, Karnofsky Performance Scale status (KPS), and the MIB-1 index were evaluated. RESULTS The incidence of ACTC1 expression as a qualitative assessment gradually increased according to WHO grade. The hazard ratio for the median overall survival (mOS) of the patients with ACTC1-positive high-grade gliomas as compared with the ACTC1-negative group was 2.96 (95% CI, 1.03–8.56). The mOS was 6.28 years in the ACTC1-negative group and 1.26 years in the positive group (p = 0.037). In GBM patients, the hazard ratio for mOS in the ACTC1-positive GBMs as compared with the ACTC1-negative group was 2.86 (95% CI 0.97–8.45). mOS was 3.20 years for patients with ACTC1-negative GBMs and 1.08 years for patients with ACTC1-positive GBMs (p = 0.048). By the radiological findings, 42.9% of ACTC1-positive GBM patients demonstrated invasion toward the contralateral cerebral hemisphere at the time of diagnosis, although no invasion was observed in ACTC1-negative GBM patients (p = 0.013). The recurrence rate of GBM was 87.5% in the ACTC1-positive group; in contrast, none of the ACTC1-negative patients demonstrated distant recurrence (0.007). No remarkable relationship was demonstrated among ACTC1 expression and patient age, KPS, and the MIB-1 index. CONCLUSIONS ACTC1 may serve as a novel independent prognostic and invasion marker in GBM.

scholarly journals The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer

2021 ◽  
Author(s):  
Lei Ruixue ◽  
Zhao Yanteng ◽  
Huang Kai ◽  
Wan Kangkang ◽  
Li Tingting ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cpg Island ◽  
Methylation Status ◽  
Tumor Location ◽  
Functional Enrichment ◽  
Superior Performance ◽  
Regulation Of Transcription ◽  
Patient Age ◽  
Patient Âgé

Methylation-based noninvasive molecular diagnostics are easy and feasible tools for the early detection of colorectal cancer (CRC). However, many of them have the limitation of low sensitivity with some CRCs detection failed in clinical practice. In this study, the clinical and pathological characteristics, as well as molecular features of three methylator-groups, defined by the promoter methylation status of SDC2 and TFPI2, were investigated in order to improve the performance of CRC detection. The Illumina Infinium 450k Human DNA methylation data and clinical information of CRCs were collected from The Cancer Genome Atlas (TCGA) project and Gene Expression Omnibus (GEO) database. CRC samples were divided into three groups, HH (dual-positive), HL (single positive) and LL (dual-negative) according to the methylation status of SDC2 and TFPI2 promoters. Differences in age, tumor location, microsatellite instable status and differentially expressed genes (DEGs) were evaluated among the three groups and these findings were then confirmed in our inner CRC dataset. The combination of methylated SDC2 and TFPI2 showed a superior performance of distinguishing CRCs from normal controls than each alone. Samples of HL group were more often originated from left-side CRCs whereas very few of them were from right-side (P < 0.05). HH grouped CRCs showed a higher level of microsatellite instability and mutation load than other two groups (mean nonsynonymous mutations for HH/HL/LL: 10.55/3.91/7.02, P = 0.0055). All mutations of BRAF, one of the five typical CpG island methylator phenotype (CIMP) related genes, were found in HH group (HH/HL/LL: 51/0/0, P = 0.018). Also there was a significantly older patient age at the diagnosis in HH group. Gene expression analysis identified 37, 84 and 22 group-specific DEGs for HH, HL and LL, respectively. Functional enrichment analysis suggested that HH specific DEGs were mainly related to the regulation of transcription and other processes, while LL specific DEGs were enriched in the biological processes of extracellular matrix interaction and cell migration. The three defined mathylator groups showed great difference in tumor location, patient age, MSI and ECM biological process, which could facilitate the development of more effective biomarkers for CRC detection.

scholarly journals Gene Expression Patterns in Ependymomas Correlate with Tumor Location, Grade, and Patient Age

2003 ◽  
Vol 163 (5) ◽  
pp. 1721-1727 ◽  
Author(s):  
Andrey Korshunov ◽  
Kai Neben ◽  
Gunnar Wrobel ◽  
Bjoern Tews ◽  
Axel Benner ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Patterns ◽  
Tumor Location ◽  
Gene Expression Patterns ◽  
Patient Age ◽  
Patient Âgé

scholarly journals Association of functional magnetic resonance imaging indices with postoperative language outcomes in patients with primary brain tumors

2013 ◽  
Vol 34 (4) ◽  
pp. E6 ◽  
Author(s):  
Bornali Kundu ◽  
Amy Penwarden ◽  
Joel M. Wood ◽  
Thomas A. Gallagher ◽  
Matthew J. Andreoli ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Clinical Setting ◽  
Tumor Location ◽  
Postoperative Outcomes ◽  
Language Mapping ◽  
Patient Age ◽  
Activation Area ◽  
Presurgical Planning ◽  
Patient Âgé

Object Functional MRI (fMRI) has the potential to be a useful presurgical planning tool to treat patients with primary brain tumor. In this study the authors retrospectively explored relationships between language-related postoperative outcomes in such patients and multiple factors, including measures estimated from task fMRI maps (proximity of lesion to functional activation area, or lesion-to-activation distance [LAD], and activation-based language lateralization, or lateralization index [LI]) used in the clinical setting for presurgical planning, as well as other factors such as patient age, patient sex, tumor grade, and tumor volume. Methods Patient information was drawn from a database of patients with brain tumors who had undergone preoperative fMRI-based language mapping of the Broca and Wernicke areas. Patients had performed a battery of tasks, including word-generation tasks and a text-versus-symbols reading task, as part of a clinical fMRI protocol. Individually thresholded task fMRI activation maps had been provided for use in the clinical setting. These clinical imaging maps were used to retrospectively estimate LAD and LI for the Broca and Wernicke areas. Results There was a relationship between postoperative language deficits and the proximity between tumor and Broca area activation (the LAD estimate), where shorter LADs were related to the presence of postoperative aphasia. Stratification by tumor location further showed that for posterior tumors within the temporal and parietal lobes, more bilaterally oriented Broca area activation (LI estimate close to 0) and a shorter Wernicke area LAD were associated with increased postoperative aphasia. Furthermore, decreasing LAD was related to decreasing LI for both Broca and Wernicke areas. Preoperative deficits were related to increasing patient age and a shorter Wernicke area LAD. Conclusions Overall, LAD and LI, as determined using fMRI in the context of these paradigms, may be useful indicators of postsurgical outcomes. Whereas tumor location may influence postoperative deficits, the results indicated that tumor proximity to an activation area might also interact with how the language network is affected as a whole by the lesion. Although the derivation of LI must be further validated in individual patients by using spatially specific statistical methods, the current results indicated that fMRI is a useful tool for predicting postoperative outcomes in patients with a single brain tumor.

Tumor location and patient age predict biological signatures of high-grade gliomas

2017 ◽  
Vol 41 (2) ◽  
pp. 599-604 ◽  
Author(s):  
Roberto Altieri ◽  
Francesco Zenga ◽  
Alessandro Ducati ◽  
Antonio Melcarne ◽  
Fabio Cofano ◽  
...  
Keyword(s):  
Tumor Location ◽  
High Grade ◽  
Patient Age ◽  
Patient Âgé ◽  
High Grade Gliomas

scholarly journals Sex Differences in Predictors of Seizure in Contrast-Enhancing Gliomas at Clinical Presentation: A Network Approach

2019 ◽  
Author(s):  
Sandra K Johnston ◽  
Aditya Khurana ◽  
Paula Whitmire ◽  
Sara Ranjbar ◽  
Akanksha Sharma ◽  
...  
Keyword(s):  
Machine Learning ◽  
Tumor Size ◽  
Clinical Presentation ◽  
Tumor Location ◽  
Data Repository ◽  
Patient Age ◽  
Entire Cohort ◽  
Prescription Practices ◽  
Patient Âgé ◽  
Co Morbidity

ABSTRACTBackgroundBrain tumor related epilepsy (BTE) is a major co-morbidity related to the management of patients with brain cancer. Despite published practice guidelines recommending against anti-epileptic drug (AED) utilization in patients with gliomas, there is heterogeneity in prescription practices of AEDs in these patients. In an attempt to impact BTE management, we statistically analyzed clinically relevant attributes (sex, age, tumor size, tumor growth kinetics, and tumor location) pertaining to seizure at presentation and used them to build a computational machine learning model to predict the probability of a seizure (at presentation).MethodsFrom our clinical data repository, we identified 223 patients (females, n=86; males, n=137) with pathologically-determined glioma and known seizure status at clinical presentation. Non-parametric and Fisher’s Exact tests were used to identify statistical differences in clinical characteristics. We utilized a random forest machine learning method for generating our predictive models by entire cohort and separated by male and female.FindingsPatients were divided into those that presented with seizure (SP, n=96, 43%; F, n= 28; M, n= 68) and those that presented without seizure (nSP, n=127, 57%, F n=58, M n=69). Females presented with seizures significantly less often than males (x2=6·28, p=0·01). SP patients had significantly smaller T1Gd radius compared to nSP (SP 11·30mm, nSP 18.66mm, p<0·0001). Tumor size and patient age were significant negative predictors for SP; patients with larger tumors, older age and less tumor diffusivity (p/D) were at lower risk for SP.InterpretationDespite heterogeneity across our patient cohort, there is strong evidence of a role for patient sex, tumor size, tumor invasion, and patient age in predicting the incidence of seizures at diagnosis. Future studies, with prospectively detailed data collection, may provide clearer insights into the incidence of seizures through a patient’s treatment course.

Number of Lymph Nodes Examined and Associated Clinicopathologic Factors in Colorectal Carcinoma

2009 ◽  
Vol 133 (5) ◽  
pp. 781-786 ◽  
Author(s):  
Steven S. Shen ◽  
Bisong X. Haupt ◽  
Jae Y. Ro ◽  
Jijiang Zhu ◽  
H. Randoph Bailey ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Lymph Nodes ◽  
Medical Center ◽  
Tumor Location ◽  
Patient Age ◽  
Bowel Segment ◽  
Patient Âgé ◽  
Clinicopathologic Factors ◽  
Resected Bowel

Abstract Context.—Nodal metastasis is one of the most important prognostic factors in colorectal carcinoma. The number of lymph nodes recovered and examined in resection specimens has been recently shown to be critical for proper staging and is associated with survival. Objective.—To assess the clinicopathologic factors that may be associated with the number of lymph nodes harvested from surgical resections. Design.—Clinicopathologic factors of 434 consecutive cases of colorectal cancers treated by surgical resection from a single tertiary medical center were retrospectively reviewed and correlated with number of lymph nodes recovered. Results.—Our data show that patient age, tumor location, and length of resected bowel segment were associated with number of lymph nodes harvested in surgical resections of colorectal cancer. The average number of lymph nodes was 18.2 and 17.8 for patients younger than 50 years and aged 50 through 60 years, respectively, whereas it was 14.4, 15.1, and 14.9 for patients aged 61 through 70 years, 71 through 80 years, and 80 years and older, respectively. More lymph nodes were present in resection specimens of cecum/ascending colon and descending colon cancers than in those of transverse colon, sigmoid colon, and rectal cancers. There was a linear increase in number of lymph nodes examined with increasing length of bowel resection specimens. In multivariate regression analysis, the factors that remained independent predictors of removal of 12 or more lymph nodes from resection specimens were tumor location and length of resected bowel segment. Conclusions.—The number of lymph nodes obtained in resection specimens for colorectal cancer was significantly associated with the length of resected segments of bowel, patient age, and location of the tumor.

Interaction Between the Contributions of Tumor Location, Tumor Grade, and Patient Age to the Survival Benefit Associated with Gross Total Resection

2018 ◽  
Vol 111 ◽  
pp. e790-e798 ◽  
Author(s):  
Kate T. Carroll ◽  
Alex K. Bryant ◽  
Brian Hirshman ◽  
Ali A. Alattar ◽  
Rushikesh Joshi ◽  
...  
Keyword(s):  
Survival Benefit ◽  
Tumor Grade ◽  
Tumor Location ◽  
Gross Total Resection ◽  
Total Resection ◽  
Patient Age ◽  
Patient Âgé

scholarly journals Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications

2021 ◽  
Vol 11 ◽  
Author(s):  
Francesco Maiuri ◽  
Giuseppe Mariniello ◽  
Oreste de Divitiis ◽  
Felice Esposito ◽  
Elia Guadagno ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Skull Base ◽  
Postmenopausal Women ◽  
Prognostic Significance ◽  
Receptor Expression ◽  
Patient Age ◽  
Who Grade ◽  
Time To Recurrence ◽  
Initial Surgery ◽  
Patient Âgé

BackgroundThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed.MethodsA surgical series of 300 patients with meningiomas is reviewed. The PR expression was classified as: 0. absent; 1. low (&lt;15%); 2. moderately low (16–50%); 3. moderately high (51–79%); 4. high (≥80%). The PR values were correlated with the patient age and sex, meningioma location, WHO grade, Ki-67 MIB1, recurrence rate, pattern of recurrence (local-peripheral versus multicentric diffuse), and time to recurrence.ResultsThe PR expression has shown lower rate of high expression in the elderly group (p = 0.032) and no sex difference (including premenopausal versus postmenopausal women), higher expression in medial skull base and spinal versus other locations (p = 0.0036), inverse correlation with WHO grade and Ki67-MIB1 (p &lt; 0.0001). Meningiomas which recurred showed at initial surgery higher rates of low or moderately low PR expression than the non-recurrent ones (p = 0.0004), whereas the pattern of regrowth was not significant. Higher rates of PR values ≥80% were found in cases with time to recurrence &gt;5 years (p = 0.036).ConclusionThe higher PR expression in medial skull base meningiomas, the significant correlation with the time to recurrence, the lack of difference of PR expression between premenopausal and postmenopausal women and between local-peripheral versus multicentric-diffuse recurrences are the most relevant unreported findings of this study. The rate of PR expression must be included in the routine pathological diagnosis of meningiomas because of its prognostic significance.

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