Subependymal giant cell astrocytoma: a lesion with activated mTOR pathway and constant expression of glutamine synthetase

2016 ◽  
Vol 35 (09) ◽  
pp. 295-301 ◽  
Author(s):  
Anna Maria Buccoliero ◽  
Chiara Caporalini ◽  
Flavio Giordano ◽  
Federico Mussa ◽  
Mirko Scagnet ◽  
...  
Keyword(s):  
Glutamine Synthetase ◽  
Giant Cell ◽  
Mtor Pathway ◽  
Subependymal Giant Cell Astrocytoma ◽  
Constant Expression ◽  
Giant Cell Astrocytoma

scholarly journals Evidence of ambiguous differentiation and mtor pathway dysregulation in subependymal giant cell astrocytoma

2012 ◽  
Vol 28 (2) ◽  
pp. 95 ◽  
Author(s):  
Brad D Barrows ◽  
Martin J Rutkowski ◽  
Sakir Humayun Gultekin ◽  
Andrew T Parsa ◽  
Tarik Tihan
Keyword(s):  
Giant Cell ◽  
Mtor Pathway ◽  
Subependymal Giant Cell Astrocytoma ◽  
Pathway Dysregulation ◽  
Giant Cell Astrocytoma

A Neonatal Huge Subependymal Giant Cell Astrocytoma

Neurosurgery ◽  
1994 ◽  
Vol 35 (4) ◽  
pp. 748-750 ◽  
Author(s):  
Susumu Oikawa ◽  
Keizo Sakamoto ◽  
Norio Kobayashi
Keyword(s):  
Giant Cell ◽  
Subependymal Giant Cell Astrocytoma ◽  
Giant Cell Astrocytoma

scholarly journals A Case of Solitary Subependymal Giant Cell Astrocytoma

2005 ◽  
Vol 7 (4) ◽  
pp. 544-549 ◽  
Author(s):  
Tomotsugu Ichikawa ◽  
Akiko Wakisaka ◽  
Shigeru Daido ◽  
Soichiro Takao ◽  
Takashi Tamiya ◽  
...  
Keyword(s):  
Giant Cell ◽  
Subependymal Giant Cell Astrocytoma ◽  
Giant Cell Astrocytoma

scholarly journals Laser interstitial thermal therapy for subependymal giant cell astrocytoma: technical case report

2016 ◽  
Vol 41 (4) ◽  
pp. E9 ◽  
Author(s):  
David Y. A. Dadey ◽  
Ashwin A. Kamath ◽  
Eric C. Leuthardt ◽  
Matthew D. Smyth
Keyword(s):  
Giant Cell ◽  
Pediatric Population ◽  
Thermal Therapy ◽  
Subependymal Giant Cell Astrocytoma ◽  
Complication Rates ◽  
Open Resection ◽  
Laser Interstitial Thermal Therapy ◽  
Intracranial Lesions ◽  
Giant Cell Astrocytoma

Subependymal giant cell astrocytoma (SEGA) is a rare tumor occurring almost exclusively in patients with tuberous sclerosis complex. Although open resection remains the standard therapy, complication rates remain high. To minimize morbidity, less invasive approaches, such as endoscope-assisted resection, radiosurgery, and chemotherapy with mTOR pathway inhibitors, are also used to treat these lesions. Laser interstitial thermal therapy (LITT) is a relatively new modality that is increasingly used to treat a variety of intracranial lesions. In this report, the authors describe two pediatric cases of SEGA that were treated with LITT. In both patients the lesion responded well to this treatment modality, with tumor shrinkage observed on follow-up MRI. These cases highlight the potential of LITT to serve as a viable minimally invasive therapeutic approach to the management of SEGAs in the pediatric population.

Subependymal giant cell astrocytoma

Neurosurgery ◽  
1991 ◽  
pp. 864 ◽  
Author(s):  
C W Shepherd ◽  
B W Scheithauer ◽  
M R Gomez ◽  
H J Altermatt ◽  
J A Katzmann
Keyword(s):  
Giant Cell ◽  
Subependymal Giant Cell Astrocytoma ◽  
Giant Cell Astrocytoma

Recurrent subependymal giant-cell astrocytoma in the absence of tuberous sclerosis

1979 ◽  
Vol 50 (1) ◽  
pp. 106-109 ◽  
Author(s):  
G. Michael Halmagyi ◽  
Leon P. Bignold ◽  
John L. Allsop
Keyword(s):  
Tuberous Sclerosis ◽  
Giant Cell ◽  
Parietal Lobe ◽  
Mural Nodule ◽  
Subependymal Giant Cell Astrocytoma ◽  
Content Type ◽  
Fine Print ◽  
Giant Cell Astrocytoma

✓ A case is described of a subependymal giant-cell astrocytoma that occurred as a mural nodule within a cyst in the parietal lobe. The tumor recurred twice over a period of 47 years despite two extensive surgical resections. Neither the patient nor any of his children suffered tuberous sclerosis, a disease with which this type of astrocytoma is associated.

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