Correlation between the pharmacological efficacy of cyclosporine and tacrolimus as evaluated by the lymphocyte immunosuppressant sensitivity test (LIST) and the MTT assay procedure in patients before and after renal transplantation

2011 ◽  
Vol 49 (02) ◽  
pp. 145-152 ◽  
Author(s):  
K. Sugiyama ◽  
K. Isogai ◽  
A. Toyama ◽  
H. Satoh ◽  
K. Saito ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Mtt Assay ◽  
Test List ◽  
Sensitivity Test ◽  
Assay Procedure ◽  
Before And After

scholarly journals Clinical Significance of the Pharmacological Efficacy of Tacrolimus Estimated by the Lymphocyte Immunosuppressant Sensitivity Test (LIST) before and after Renal Transplantation

Cell Medicine ◽  
2012 ◽  
Vol 3 (1-3) ◽  
pp. 81-88 ◽  
Author(s):  
Kentaro Sugiyama ◽  
Kazuya Isogai ◽  
Akira Toyama ◽  
Hiroshi Satoh ◽  
Kazuhide Saito ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Clinical Significance ◽  
Test List ◽  
Sensitivity Test ◽  
Before And After

scholarly journals P0299EVALUATION OF THE CORRELATION BETWEEN VITAMIN D LEVELS AND THROMBOCYTE MARKERS IN PATIENTS WITH DİALYSİS, CHRONIC RENAL DISEASE AND RENAL TRANSPLANTATION PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
KÖNÜL AHMEDOVA ◽  
Garip SAHIN ◽  
Cengiz Bal ◽  
Rüya Mutluay
Keyword(s):  
Vitamin D ◽  
Renal Transplantation ◽  
Renal Disease ◽  
Negative Correlation ◽  
Chronic Renal Disease ◽  
Significant Negative Correlation ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Before And After ◽  
Grade 3

Abstract Background and Aims 25(OH)D3 levels are known to be lower in patients with chronic renal disease (CRD). Vitamin D supplementation has been shown to have beneficial effects on mortality in these patients. In our study, we have evaluated the pleiotropic effect of vitamin D on thrombocyte markers, which is known very little by most. Method The main thrombocyte function markers (MPV, PDW and PCT) were obtained in patients which underwent dialysis, renal transplantation and patients with grade 3-4 CRD before and after vitamin D supplementation. 40 healthy individuals were chosen as control group and 24 patients underwent renal transplantation, 25 patients underwent dialysis for at least 3 months, 32 patients were diagnosed as Grade 3-4 CRD. All of the patients above had 25(OH)D3 levels <20ng/mL (<50nmol/L). Thrombocyte markers were evaluated before and after vitamin D supplementation (which was given 50.000 IU orally once a week for 8 weeks). Results Statistically no significant difference were found between MPV values in- and across- group comparison before and after vitamin D supplementation. After the correlation analyses were reviewed, statistically significant negative correlation was found (r=-0,422 p<0.05) between ΔMPV and ΔVitamin D in renal transplantation group. Also statistically significant positive correlation was found between ΔPDW and ΔVitamin D. In the control group with healty participants, a statistically significant negative correlation was found (r=-0,493 p<0.05) between ΔVitamin D and ΔThrombocyte count. In the dialysis group a statistically significant negative correlation was found (r=-0,422 p<0.05) between ΔVitamin D and ΔMPV. Conclusion A significant correlation was found particularly between Vitamin D and MPV in dialysis and renal transplantation patients. In order to prevent cardiovascular events due to thrombosis caused by Vitamin D deficiency which increases MPV, it has been thought that Vitamin D supplementation and antiaggregant therapy might be beneficial.

EVALUATION OF PATIENTʼS SEXUAL FUNCTION BEFORE AND AFTER RENAL TRANSPLANTATION

2010 ◽  
Vol 90 ◽  
pp. 932
Author(s):  
Darabi M.R. Mahboub ◽  
R. Taghavi ◽  
M. H. Shakibi
Keyword(s):  
Renal Transplantation ◽  
Sexual Function ◽  
Before And After

scholarly journals Impact of Changing Trend in Cold Ischaemic Time on Operating Times in Renal Transplantation

2006 ◽  
Vol 88 (7) ◽  
pp. 667-671 ◽  
Author(s):  
Ying-Ying Seow ◽  
Hany Riad ◽  
Philip Dyer
Keyword(s):  
Renal Transplantation ◽  
Working Hours ◽  
Out Of Hours ◽  
Time Of Surgery ◽  
European Working ◽  
Before And After ◽  
Changing Trend ◽  
Cadaver Kidney ◽  
Time Periods ◽  
Working Time Directive

INTRODUCTION The European Working Time Directive (EWTD) is calling for reduction in the working hours of doctors. Renal transplantation is well-recognised as an out-of-hours specialty. Our study looks at whether our renal transplant centre's attempt to reduce cold ischaemic time (CIT) has impacted on the pattern of operating times since this may have implications on the surgeons' working hours. PATIENTS AND METHODS We studied 883 adult cadaver kidney transplants performed between 1 January 1992 and 31 December 2002. CIT and time of surgery was obtained from a local audit database (< www.nwkta.org >) and that held by UK Transplant. Time of surgery was divided into 07:30–17:59 (day),18:00–23:59 (evening) and 00:00–07:29 (night). RESULTS CIT has decreased since 1992, with a significant reduction after 1998 (P = 0.0001). There was, however, no difference in the percentage of operations performed during the three time periods before and after 1998. Between 1999–2002, 51.4% of transplants took place out of hours (i.e. 18:00–07:29). CONCLUSIONS Reduction in CIT does not appear to have impacted on our operating times. The large amount of out-of-hours work is, however, not compliant with EWTD requirements.

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