A phase I, single-dose study of the disposition of 14C-radiolabeled gabapentin enacarbil in healthy male volunteers

2011 ◽  
Vol 49 (02) ◽  
pp. 109-115 ◽  
Author(s):  
R. Lal ◽  
J. Sukbuntherng ◽  
J. Ho ◽  
K.C. Cundy
Keyword(s):  
Single Dose ◽  
Phase I ◽  
Healthy Male ◽  
Gabapentin Enacarbil ◽  
Single Dose Study ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Dose Study

Pharmacokinetic of Rhein in Healthy Male Volunteers Following Oral and Retention Enema Administration of Rhubarb Extract: A Single Dose Study

2005 ◽  
Vol 33 (06) ◽  
pp. 839-850 ◽  
Author(s):  
Wei Zhu ◽  
Xue-Mei Wang ◽  
Li Zhang ◽  
Xiao-Ye Li ◽  
Bao-Xiu Wang
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Dosage Adjustment ◽  
Pharmacokinetic Parameters ◽  
Healthy Male ◽  
Single Dose Study ◽  
Retention Enema ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Dose Study

Rhubarb is a common herb used in traditional Chinese medicine. However, few publications exist about its pharmacokinetic profiles in animals or healthy volunteers. Whether retention enema administration of rhubarb extract affects its pharmacokinetics as well as its tolerability is unknown. Therefore, we set out to compare the pharmacokinetic parameters of rhein administered by retention enemas with those of conventional oral dosing of rhubarb extract. Eight healthy male volunteers were enrolled in a prospective crossover study. All subjects received a single dose of rhubarb extract (50 mg·kg-1) on two separate occasions, once orally, once by a retention enema. Rhein plasma concentration was measured by HPLC. The C max , AUC 0-∞, AUMC were significantly higher in oral administration than those in retention enema administration ( p < 0.05), while V d of rhein after oral administration of rhubarb extract was significantly lower ( p < 0.05) than that after retention enema administration. However, no statistically significant differences between the two treatments were observed for any of the other pharmacokinetic parameters ( T max , t 1/2, MRT 0-∞, CL ). Dosage adjustment is advisable for retention enema administration of rhubarb extract in patients.

scholarly journals A first‐in‐human oral dose study of mesdopetam (IRL790) to assess its safety, tolerability, and pharmacokinetics in healthy male volunteers

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Folke Sjöberg ◽  
Susanna Waters ◽  
Boel Löfberg ◽  
Clas Sonesson ◽  
Nicholas Waters ◽  
...  
Keyword(s):  
Oral Dose ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Dose Study
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