Cyclosporin A, but not everolimus, inhibits DNA repair in human fibroblasts and lymphoblasts

2009 ◽  
Vol 47 (01) ◽  
pp. 38-40 ◽  
Author(s):  
C. Kuschal ◽  
K.-M. Thoms ◽  
T. Mori ◽  
N. Kobayashi ◽  
L. Böckmann ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cyclosporin A ◽  
Human Fibroblasts

Complexity of the primary genetic response to mitogenic activation of human T cells

1989 ◽  
Vol 9 (3) ◽  
pp. 1041-1048
Author(s):  
P F Zipfel ◽  
S G Irving ◽  
K Kelly ◽  
U Siebenlist
Keyword(s):  
T Cells ◽  
Cyclosporin A ◽  
Human Peripheral Blood ◽  
Human Fibroblasts ◽  
Primary Response ◽  
Cdna Clones ◽  
Genetic Response ◽  
Activated T Cells ◽  
Isolation And Characterization ◽  
Inducible Genes

We describe the isolation and characterization of more than 60 novel cDNA clones that constitute part of the immediate genetic response to resting human peripheral blood T cells after mitogen activation. This primary response was highly complex, both in the absolute number of inducible genes and in the diversity of regulation. Although most of the genes expressed in activated T cells were shared with the activation response of normal human fibroblasts, a significant number were more restricted in tissue specificity and thus likely encode or effect the differentiated functions of activated T cells. The activatable genes could be further differentiated on the basis of kinetics of induction, response to cycloheximide, and sensitivity to the immunosuppressive drug cyclosporin A. It is of note that cyclosporin A inhibited the expression of more than 10 inducible genes, which suggests that this drug has a broad genetic mechanism of action.

Rate of DNA repair in progeric and normal human fibroblasts

1974 ◽  
Vol 59 (3) ◽  
pp. 850-857 ◽  
Author(s):  
J. Epstein ◽  
Jerry R. Williams ◽  
John B. Little
Keyword(s):  
Dna Repair ◽  
Human Fibroblasts ◽  
Normal Human

The DNA repair capacity of human fibroblasts declines with donor age

1998 ◽  
Vol 16 ◽  
pp. S219 ◽  
Author(s):  
F. Gad ◽  
M. Yaar ◽  
M.S. Eller ◽  
B.A. Gilchrest
Keyword(s):  
Dna Repair ◽  
Human Fibroblasts ◽  
Donor Age ◽  
Repair Capacity ◽  
Dna Repair Capacity

Effect of cyclosporin A on DNA repair and cancer incidence in kidney transplant recipients

2001 ◽  
Vol 137 (1) ◽  
pp. 14-20 ◽  
Author(s):  
Michal Herman ◽  
Talia Weinstein ◽  
Asher Korzets ◽  
Avry Chagnac ◽  
Yaacov Ori ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cyclosporin A ◽  
Kidney Transplant ◽  
Cancer Incidence ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Cyclosporin A inhibits H2O2-induced apoptosis of human fibroblasts

FEBS Letters ◽  
1999 ◽  
Vol 447 (2-3) ◽  
pp. 274-276 ◽  
Author(s):  
Naoyuki Sugano ◽  
Koichi Ito ◽  
Seidai Murai
Keyword(s):  
Cyclosporin A ◽  
Human Fibroblasts ◽  
Induced Apoptosis
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