Association between neuroleptic drug-induced extrapyramidal symptoms and dopamine D2-receptor polymorphisms in Japanese schizophrenic patients

2005 ◽  
Vol 43 (04) ◽  
pp. 163-171 ◽  
Author(s):  
Y. Nakazono ◽  
H. Abe ◽  
H. Murakami ◽  
N. Koyabu ◽  
Y. Isaka ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Extrapyramidal Symptoms ◽  
Neuroleptic Drug ◽  
Drug Induced ◽  
Dopamine D2 ◽  
Schizophrenic Patients

Relevance of the dopamine D2 receptor blockade in clinical response to neuroleptic treatment in schizophrenic patients

1989 ◽  
Vol 2 (1-2) ◽  
pp. 207
Author(s):  
Ana Hitri ◽  
Parvathi Mohan ◽  
Dharmber Sinha ◽  
James Harrold ◽  
BruceI. Diamond ◽  
...  
Keyword(s):  
Clinical Response ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Blockade ◽  
Neuroleptic Treatment ◽  
Dopamine D2 ◽  
Schizophrenic Patients

Dopamine D2 receptor gene −141C Insertion/Deletion polymorphism in Turkish schizophrenic patients

2010 ◽  
Vol 38 (2) ◽  
pp. 1407-1411 ◽  
Author(s):  
Hulyam Kurt ◽  
Miris Dikmen ◽  
Ayşe Basaran ◽  
Cinar Yenilmez ◽  
Figen Ozdemir ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
Receptor Gene ◽  
D2 Receptor ◽  
Deletion Polymorphism ◽  
Dopamine D2 ◽  
Schizophrenic Patients

EXTRASTRIATAL DOPAMINE D2 RECEPTOR BINDING POTENTIALS IN ANTIPSYCHOTIC-NAÏVE FIRST-EPISODE SCHIZOPHRENIC PATIENTS

2008 ◽  
Vol 102 (1-3) ◽  
pp. 42
Author(s):  
Birte Glenthøj ◽  
Hans Rasmussen ◽  
Torben Mackeprang ◽  
Claus Svarer ◽  
Lars Pinborg ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
First Episode ◽  
Dopamine D2 ◽  
Schizophrenic Patients

scholarly journals Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia

2020 ◽  
Vol 71 (10) ◽  
pp. 182-192
Author(s):  
Muhammad Ashfaq ◽  
S. Mobasher Ali Abid ◽  
Khalid Rauf ◽  
Yasser Msa Alkahraman ◽  
Muhammad Zeeshan Haroon ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dopamine Receptors ◽  
Proton Pump ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Md Simulations ◽  
Serum Prolactin ◽  
Drug Induced ◽  
Dopamine D2

Dopamine is a catecholamine neurotransmitter that control several important functions via different dopamine receptors(D1-D5). The Dopamine (DRD2) receptor and other D2 family receptors (D3 and D4) are predominantly involved in the inhibitory activities. One vital role of dopamine receptors is its involvement in the endocrine regulations including the hormone synthesis and their secretion. The regulation of prolactin hormone is mainly controlled through DRD2 receptors. Blocking the delivery of dopamine at these DRD2 receptors will cause an increase in serum prolactin levels. PPI�s are among the widely prescribed medications used for multiple gastric hypersecretory disorders and are shown to cause increase in serum prolactin level. This study focuses on computational methods to test PPIs interaction with dopamine D2 receptor through molecular docking & dynamics studies. The 3D structure of protein and the drugs were downloaded from PDB and PubChem databases. Protein and ligands were prepared followed by molecular docking. Complexes with best docking poses were then proceeded towards MD simulations of 60 ns. Results were then analyzed. This study confirmed that there is prospective affinity between proton pump inhibitors and dopamine D2 receptor, and dynamically stable complexes are formed after drug-receptor binding. MD simulations results confirmed the binding affinity between PPIs and Dopamine D2 receptor, concluding that the use of PPIs may be involved in drug induced hyperprolactinemia and other related effects.

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