Bioequivalence of a prednisolone tablet administered as a single oral dose in healthy male volunteers

2004 ◽  
Vol 42 (09) ◽  
pp. 519-525
Author(s):  
H.J. Lee ◽  
J.Y. Yoo ◽  
Y.G. Kim ◽  
S.B. Han ◽  
K.R. Lee
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers

Effect of Food on the Pharmacokinetics of a Single Oral Dose of Moxifloxacin 400mg in Healthy Male Volunteers

2001 ◽  
Vol 40 (Supplement 1) ◽  
pp. 19-25 ◽  
Author(s):  
John Lettieri ◽  
Ramon Vargas ◽  
Vipin Agarwal ◽  
Patrick Liu
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Effect Of Food

Pharmacokinetics and metabolism of genaconazole, a potent antifungal drug, in men.

1996 ◽  
Vol 40 (1) ◽  
pp. 92-96 ◽  
Author(s):  
C Lin ◽  
H Kim ◽  
E Radwanski ◽  
M Affrime ◽  
M Brannan ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Total Radioactivity ◽  
Healthy Male ◽  
Serum Samples ◽  
Time Curve ◽  
Concentration Time ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
The Mean

The pharmacokinetics of genaconazole, a racemic triazole antifungal agent comprising 50% RR and 50% SS enantiomers, were studied in 12 healthy male volunteers after a single oral dose of 200 mg. The serum samples were analyzed for the two enantiomers by using a chiral high-pressure liquid chromatography assay. The concentrations of the RR and SS enantiomers in serum were virtually identical. The mean values for the maximum concentrations in serum (Cmax) (1.7 micrograms/ml), times to Cmax (4.0 to 4.2 h), half-lives (83 h), and areas under the concentration-time curve from 0 h to infinity (195 to 199 micrograms.h/ml) were similar for the two enantiomers. The results showed that the pharmacokinetic profiles of the two enantiomers were similar after a single oral dosing of the racemate. The pharmacokinetics of the RR enantiomer were also evaluated in 12 healthy male volunteers after a single oral dose of 100 or 200 mg. The ratios of the Cmaxs and of the areas under the concentration-time curves from 0 h to infinity for the two doses were about 2, indicating a dose proportionality. In a separate study, six healthy male volunteers received a single oral dose of 50 mg of 14C-labeled genaconazole. The Cmax values for total radioactivity (14C) and intact genaconazole were virtually identical (0.6 micrograms/ml). The mean half-lives in serum were about 73 h for both total radioactivity and genaconazole. The amounts of total radioactivity excreted in the 0 to 240-h interval (representing approximately three half-lives) in urine and feces were 66.6 and 9.3% of the dose, respectively; 64.4% of the dose was excreted in urine as parent drug. There were no detectable metabolites in either serum or urine. The data demonstrate that genaconazole (racemate) is well absorbed, undergoes negligible biotransformation, and is slowly excreted, primarily in the urine.

Pharmacokinetics, disposition and biotransformation of [14C]-radiolabelled valsartan in healthy male volunteers after a single oral dose

Xenobiotica ◽  
1997 ◽  
Vol 27 (1) ◽  
pp. 59-71 ◽  
Author(s):  
F. Waldmeier ◽  
G. Flesch ◽  
P. Mu Ller ◽  
T. Winkler ◽  
H.- P. Kriemler ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers

scholarly journals A first‐in‐human oral dose study of mesdopetam (IRL790) to assess its safety, tolerability, and pharmacokinetics in healthy male volunteers

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Folke Sjöberg ◽  
Susanna Waters ◽  
Boel Löfberg ◽  
Clas Sonesson ◽  
Nicholas Waters ◽  
...  
Keyword(s):  
Oral Dose ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Dose Study
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