Prevalence of and factors associated with the prescription of phytopharmaceuticals in outpatients with urinary tract infections

Author(s):  
Conrad Ehrenberg ◽  
Matthias Kalder ◽  
Karel Kostev
2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S826-S827
Author(s):  
Leigh Ellyn Preston ◽  
Clifford McDonald ◽  
Babatunde Olubajo ◽  
Natalie McCarthy ◽  
Sujan Reddy ◽  
...  

Abstract Background Community-onset urinary tract infections (coUTIs) are one of the most common indications for antibiotic prescribing. It is important to understand patient demographic factors associated with microorganisms causing coUTI and their antibiotic resistance profiles, to tailor antibiotic prescribing practices. We analyzed microbiology data to understand factors associated with coUTI in the United States (US). Methods CoUTIs were identified in the Premier Healthcare Database and Cerner Health Facts among patients treated at participating healthcare facilities in the US between 2012-2017. Cases were defined by urine cultures yielding a bacterial organism and were collected in outpatient settings or within three days of hospitalization. Only the first specimen for each encounter was included in the analysis. Data on the organisms isolated, patient’s age, sex, and US census regions of the submitting facilities were described and compared using chi-square tests for associations. Encounters were classified as inpatient (INPT), observation (OBS), emergency department (ED), and outpatient (OTPT) based on the setting in which the culture was submitted. Results Using data from 637 acute care hospitals, urine samples from 3,291,561 encounters were included, with 776,653 (25.7%) INPT, 1,063,219 (34.8%) ED, 107,760 (3.5%) OBS, and 1,092,658 (35.8%) OTPT. The pathogens most frequently associated with coUTIs were Escherichia coli (57.3%), Klebsiella pneumoniae (9.7%), Enterococcus faecalis (5.1%), Proteus mirabilis (4.9%), and Pseudomonas aeruginosa (2.9%). Female sex, age < 65y and OTPT and ED settings were associated with higher relative frequency of E. coli (all p < 0.0001). Male sex, INPT setting and age >65 y were associated with higher relative frequency of P. aeruginosa, P. mirabilis and E. faecalis (all p < 0.0001, Figure). K. pneumoniae was found at higher relative frequency in those >45y, and in INPT and OBS settings (all p < 0.0001). Figure. Distribution of pathogens most frequently associated with community onset urinary tract infections Conclusion Understanding patient factors associated with the microbiology of coUTIs is an important step in developing treatment recommendations and antibiotic stewardship efforts. Further analyses will include assessing the impact of major antibiotic resistance phenotypes, geographic and healthcare settings. Disclosures All Authors: No reported disclosures


2016 ◽  
Vol 21 (2) ◽  
pp. 62-66
Author(s):  
Eng Kiang Lee ◽  
Alvin Teo ◽  
Gillian Land ◽  
Sue Borrell ◽  
Denis Spelman ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Martin Odoki ◽  
Adamu Almustapha Aliero ◽  
Julius Tibyangye ◽  
Josephat Nyabayo Maniga ◽  
Eddie Wampande ◽  
...  

Urinary tract infections (UTIs) are one of the major causes of morbidity and comorbidities in patients with underlying conditions, and it accounts for the majority of the reasons for hospital visit globally. Sound knowledge of factors associated with UTI may allow timely intervention that can easily bring the disease under control. This study was designed to determine the prevalence of UTI by isolating and characterizing the different bacterial etiological agents and to evaluate the factors associated with UTI. In this cross-sectional study, a total of 267, clean catch midstream urine (MSU) samples were collected aseptically and analyzed using standard microbiology methods. Data for the factors associated with UTI were obtained by use of questionnaires and standard laboratory tests for selected underlying conditions. The study revealed 86/267 (32.2%) UTI prevalence among patients attending hospitals in Bushenyi District, Uganda. Escherichia coli was the most prevalent bacterial uropathogen with 36/86 (41.9%) followed by Staphylococcus aureus 27/86 (31.4%), Klebsiella pneumoniae 10/86 (11.6%), Klebsiella oxytoca 6/86 (7.0%), Proteus mirabilis 3/86 (3.5%), Enterococcus faecalis 3/86 (3.5%), and Proteus vulgaris 1/86 (1.2%). This study has demonstrated that age ≤19 years, female gender, married individuals, genitourinary tract abnormalities, diabetes, hospitalization, indwelling catheter <6 days, and indwelling catheter >6 days had statistically significant relationships (p<0.05) with UTI. Screening for UTI in hospitalized patients, female gender, married individuals, genitourinary tract abnormalities, indwelling catheter, and diabetics should be adopted.


2015 ◽  
Vol 33 (10) ◽  
pp. 1473-1476 ◽  
Author(s):  
Lara Kratochwill ◽  
Margaret Powers ◽  
Molly A. McGraw ◽  
Lauren King ◽  
John M. O'Neill ◽  
...  

2010 ◽  
Vol 50 (2) ◽  
pp. 132-135 ◽  
Author(s):  
Irene Eriksson ◽  
Yngve Gustafson ◽  
Lisbeth Fagerström ◽  
Birgitta Olofsson

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190564 ◽  
Author(s):  
Agata Skrzat-Klapaczyńska ◽  
Bartłomiej Matłosz ◽  
Agnieszka Bednarska ◽  
Marcin Paciorek ◽  
Ewa Firląg-Burkacka ◽  
...  

Author(s):  
Lisiane Martins Volcão ◽  
Juliano Pereira Lacava ◽  
Ivy Bastos Ramis ◽  
Daniela Fernandes Ramos ◽  
Gustavo Souto Damati ◽  
...  

Background and Objectives: Fluoroquinolones are one of the most frequently prescribed antimicrobial classes for the treatment of urinary tract infections (UTIs) of both hospital and community origin. This study aims to determine the frequency and the factors associated with resistance to ciprofloxacin and levofloxacin in gram-negative bacilli isolated from patients with UTIs treated in a hospital in southern Brazil. Methods: We performed a transversal and analytical study based on cases of urinary tract infection caused by gram-negative bacteria (GNB) in patients at the Hospital Universitário Dr. Miguel Riet Correa Jr. in Rio Grande/RS from August 2012 to July 2013. Independent variables such as the age and sex of patients, source of infection of the UTI and the characteristics of the bacterial strains were analyzed. Results: Of the 562 GNB analyzed, the total frequencies of ciprofloxacin and levofloxacin resistance were, respectively, 25.5% and 23.3% in strains of community origin and 62.6% and 59% in strains of hospital origin. The risk factors associated with ciprofloxacin and levofloxacin resistance were sex (male), infections acquired in the hospital, longer hospitalization times, and the presence of extended spectrum β-lactamases (ESBLs) in the bacterial strains. Conclusions: We observed a strong association between GNB resistance, the time spent in the hospital and the presence of ESBLs. To control antibiotic resistance and to reduce the cost of health care, a strong hospital policy of vigilance is required regarding the use of and resistance to antibiotics.


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