scholarly journals Randomized, double-blind, two-way crossover bioequivalence and adhesion study, in healthy women, of a transdermal contraceptive patch with a newly sourced adhesive component at the end of shelf life vs. the EVRA patch at the beginning of shelf life

2021 ◽  
Author(s):  
Madhu Sanga ◽  
Subusola Vaughan ◽  
Julius Nangosyah ◽  
Veronika Scholz ◽  
Sergio Fonseca
Keyword(s):  
Shelf Life ◽  
Double Blind ◽  
Healthy Women ◽  
Contraceptive Patch

Comparison of a transdermal contraceptive patch with a newly sourced adhesive component versus EVRA patch: A double-blind, randomized, bioequivalence and adhesion study in healthy women

Contraception ◽  
2020 ◽  
Vol 101 (4) ◽  
pp. 276-282 ◽  
Author(s):  
Dolly A. Parasrampuria ◽  
Subusola Vaughan ◽  
Jay Ariyawansa ◽  
Aline Swinnen ◽  
Jaya Natarajan ◽  
...  
Keyword(s):  
Double Blind ◽  
Healthy Women ◽  
Contraceptive Patch

scholarly journals Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1071
Author(s):  
Toshihiko Shoji ◽  
Saeko Masumoto ◽  
Nina Moriichi ◽  
Yasuyuki Ohtake ◽  
Tomomasa Kanda
Keyword(s):  
Clinical Trial ◽  
Uv Irradiation ◽  
Skin Pigmentation ◽  
Controlled Clinical Trial ◽  
Continuous Administration ◽  
Double Blind ◽  
Healthy Women ◽  
Dependent Relationship ◽  
Skin Conditions ◽  
Double Blinded

This clinical study was performed to evaluate the effects of continuous apple polyphenol (AP) administration on facial skin conditions and pigmentation induced by ultraviolet (UV) irradiation in healthy women participants. Participants (n = 65, age 20–39 years) were randomized to receive tablets containing AP (300 or 600 mg/day) or placebo in a double-blinded, placebo-controlled clinical trial. Continuous administration of AP for 12 weeks significantly prevented UV irradiation induced skin pigmentation (erythema value, melanin value, L value), although a dose-dependent relationship was not clearly observed. In contrast, no significant differences were detected between the groups with regard to water content and trans-epidermal water loss. Our study demonstrated that APs and their major active compounds, procyanidins, have several health benefits. Here, we report that continuous administration of AP for 12 weeks alleviated UV irradiation induced skin pigmentation, when compared with placebo, in healthy women.

Insulin-like growth factors I and II in healthy women with and without established osteoporosis

1995 ◽  
Vol 132 (3) ◽  
pp. 313-319 ◽  
Author(s):  
P Ravn ◽  
K Overgaard ◽  
EM Spencer ◽  
C Christiansen
Keyword(s):  
Growth Factors ◽  
Anabolic Steroids ◽  
Hormone Replacement ◽  
Basic Research ◽  
Treated Group ◽  
Double Blind ◽  
Healthy Women ◽  
Established Osteoporosis ◽  
Igf I ◽  
Insulin Like Growth Factors

Ravn P, Overgaard K, Spencer EM, Christiansen C. Insulin-like growth factors I and II in healthy women with and without established osteoporosis. Eur J Endocrinol 1995;132:313–9. ISSN 0804–4643 We measured serum concentrations of insulin-like growth factors I and II (IGF-I and IGF-II) by radioimmunoassay in 107 healthy women aged 28–78 years and in 116 women with established osteoporosis. The women with established osteoporosis were randomized to a 1-year double-blind, placebo-controlled treatment with continuous estrogen/progestogen, anabolic steroids, salmon calcitonin or placebo and the IGFs were measured every 6 months. Women less than 35 years of age had 29% higher levels of IGF-I (p < 0.001) as compared to women above that age. For women more than 35 years of age, we found no correlation between IGF-I and age (r = 0.02). Correspondingly, we found no significant changes in serum IGF-I in 10 women, who were followed with serial measurements of IGFs every 3 months from 2 years before to 1 year after menopause; IGF-II revealed no correlation with age (r = 0.04). In the group of 116 women with established osteoporosis, IGF-I was 30% lower (p < 0.01) as compared to a group of 19 height-, weight- and age-matched nonfractured women (mean age 64 years). The IGF-II levels were equal in the two groups. Over the 1-year therapeutic intervention period, an increase in IGF-I of 13–15% (p < 0.05) was seen in the nandrolone decanoate-treated group. The same tendency was seen for hormone replacement therapy, although it was not significant. In conclusion, the serum level of IGF-I is high in young women, when peak bone mass is attained, and low in postmenopausal women with established osteoporosis. Pernille Ravn, Center for Clinical & Basic Research, Ballerup Byvej 222, DK-2750 Ballerup, Denmark

scholarly journals Effect of a proprietary Magnolia and Phellodendronextract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial

2008 ◽  
Vol 7 (1) ◽  
Author(s):  
Douglas S Kalman ◽  
Samantha Feldman ◽  
Robert Feldman ◽  
Howard I Schwartz ◽  
Diane R Krieger ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Healthy Women ◽  
Stress Levels

Potato protease inhibitor II suppresses postprandial appetite in healthy women: a randomized double-blind placebo-controlled trial

2017 ◽  
Vol 8 (5) ◽  
pp. 1988-1993 ◽  
Author(s):  
Yong Zhu ◽  
Joanne A. Lasrado ◽  
Jiang Hu
Keyword(s):  
Protease Inhibitor ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Healthy Women

The effect of potato protease inhibitor II (PI2) on postprandial appetite was examined in a randomized double-blind placebo-controlled cross-over trial involving 44 healthy women.

Multiple-dose pharmacokinetics of a contraceptive patch in healthy women participants

Contraception ◽  
2001 ◽  
Vol 64 (5) ◽  
pp. 287-294 ◽  
Author(s):  
Larry S. Abrams ◽  
Donna M. Skee ◽  
Jaya Natarajan ◽  
Frankie A. Wong ◽  
Kenneth C. Lasseter
Keyword(s):  
Multiple Dose ◽  
Healthy Women ◽  
Multiple Dose Pharmacokinetics ◽  
Contraceptive Patch
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