Current status of adverse event profile of tacrolimus in patients with solid organ transplantation from a pharmacovigilance study

2021 ◽  
Author(s):  
Hiroko Kambara ◽  
Saki Oyama ◽  
Ayaka Inada ◽  
Iku Niinomi ◽  
Tomohito Wakabayashi ◽  
...  
Keyword(s):  
Adverse Event ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Current Status ◽  
Solid Organ ◽  
Adverse Event Profile

scholarly journals Current Status of Research on Osteoporosis after Solid Organ Transplantation: Pathogenesis and Management

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Gong-bin Lan ◽  
Xu-biao Xie ◽  
Long-kai Peng ◽  
Lei Liu ◽  
Lei Song ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Immunosuppressive Agents ◽  
Solid Organ Transplantation ◽  
Treatment Strategies ◽  
Current Status ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Metabolic Bone

Improved survival following organ transplantation has brought to the forefront some long-term complications, among which osteoporosis and associated fractures are the major ones that adversely affect the quality of life in recipients. The pathogenesis of osteoporosis in transplant recipients is complex and multifactorial which may be related to increased bone resorption, decreased bone formation, or both. Studies have shown that the preexisting underlying metabolic bone disorders and the use of immunosuppressive agents are the major risk factors for osteoporosis and fractures after organ transplantation. And rapid bone loss usually occurs in the first 6–12 months with a significant increase in fracture risk. This paper will provide an updated review on the possible pathogenesis of posttransplant osteoporosis and fractures, the natural history, and the current prevention and treatment strategies concerning different types of organ transplantation.

scholarly journals Current Status of Glucocorticoid Usage in Solid Organ Transplantation

2021 ◽  
Author(s):  
Simin Dashti-Khavidaki ◽  
Reza Saidi ◽  
Hong Lu
Keyword(s):  
Side Effects ◽  
Immunosuppressive Therapy ◽  
Organ Transplantation ◽  
Targeted Delivery ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Solid Organ Transplantation ◽  
Current Status ◽  
Solid Organ ◽  
Advantages And Disadvantages

Glucocorticoids (GCs) have been the mainstay of immunosuppressive therapy in solid organ transplantation (SOT) for decades due to their potent effects on the innate immunity and tissue protective effects. But, some SOT centers are reluctant to administer GCs for long-time due to the various side effects. This review summarizes advantages and disadvantages of GCs in SOT. PubMed and Scopus databases were searched from 2011 to April 2021 using search syntaxes cover “transplantation” and “glucocorticoids”.GCs are used in transplant recipients, transplant donors, and organ perfusate solution to improve transplant outcomes. In SOT recipients GCs are administered as induction and maintenance immunosuppressive therapy. GCs are also the cornerstone to treat acute anti-body- and T-cell-mediated rejections. Addition of GCs to organ perfusate solution and pretreatment of transplant donors with GCs are recommended by some guidelines and protocols to reduce ischemia-reperfusion injury peri-transplant. GCs with low bioavailability and high potency for GC receptors such as budesonide, nanoparticle-mediated targeted delivery of GCs to specific organs, and combination use of dexamethasone with inducers of immune-regulatory cells are new methods of GC usage in SOT patients to reduce side effects or induce immune-tolerance instead of immunosuppression. Various side effects on different non-targeted organs/tissues such as bone, cardiovascular, neuromuscular, skin, and gastrointestinal tract have been noted for GCs. There are also potential drug-drug interactions for GCs in SOT patients.

scholarly journals Solid-Organ Transplantation in Older Adults: Current Status and Future Research

2012 ◽  
Vol 12 (10) ◽  
pp. 2608-2622 ◽  
Author(s):  
M. Abecassis ◽  
N. D. Bridges ◽  
C. J. Clancy ◽  
M. A. Dew ◽  
B. Eldadah ◽  
...  
Keyword(s):  
Older Adults ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Current Status ◽  
Future Research ◽  
Solid Organ

scholarly journals Current status of glucocorticoid usage in solid organ transplantation

2021 ◽  
Vol 11 (11) ◽  
pp. 443-465
Author(s):  
Simin Dashti-Khavidaki ◽  
Reza Saidi ◽  
Hong Lu
Keyword(s):  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Current Status ◽  
Solid Organ

scholarly journals Regenerative medicine as applied to solid organ transplantation: current status and future challenges

2010 ◽  
Vol 24 (3) ◽  
pp. 223-232 ◽  
Author(s):  
Giuseppe Orlando ◽  
Pedro Baptista ◽  
Martin Birchall ◽  
Paolo De Coppi ◽  
Alan Farney ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Organ Transplantation ◽  
Solid Organ Transplantation ◽  
Current Status ◽  
Solid Organ ◽  
Future Challenges

The interactive effect of parent personality and medication knowledge on adherence in children awaiting solid organ transplantation.

2017 ◽  
Vol 36 (5) ◽  
pp. 445-448 ◽  
Author(s):  
Jennifer L. Lee ◽  
Cyd K. Eaton ◽  
Kristin Loiselle Rich ◽  
Bonney Reed-Knight ◽  
Rochelle S. Liverman ◽  
...  
Keyword(s):  
Organ Transplantation ◽  
Interactive Effect ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Medication Knowledge ◽  
Parent Personality
Sign in / Sign up

Export Citation Format

Share Document