11β-hydroxysteroid dehydrogenase type 1 is associated with antiretroviral therapy-induced increase in low-density lipoprotein cholesterol

2019 ◽  
Vol 57 (06) ◽  
pp. 298-305
Author(s):  
Kazuyuki Niki ◽  
Kazuo Harada ◽  
Shinich Hikasa ◽  
Mamiko Tsugane ◽  
Mikiko Ueda ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hydroxysteroid Dehydrogenase ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Vitamin D levels are associated with low-density lipoprotein cholesterol in Chinese children with type 1 diabetes

2021 ◽  
Author(s):  
Jianbo Shu ◽  
Xinhui Wang ◽  
Mingying Zhang ◽  
Xiufang Zhi ◽  
Jun Guan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Nonlinear Relationship ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Vitamin D Levels

Abstract Objective There is an increased level of low-density lipoprotein cholesterol (LDL-C)in children with type 1 diabetes mellitus(T1DM). In addition, the Vitamin D level in T1DM patients is usually below the normal reference range. The aim of this study was to explore the relationship between Vitamin D levels and LDL-C in Chinese children with T1DM. Methods A retrospective cross-sectional study was conducted in the Endocrine inpatient wards of Tianjin Children’s Hospital, 143 children with T1DM were included. The related clinical and laboratory examinations, including anthropometric parameters, lipid profiles, and Vitamin D levels, were collected in all subjects. Results The univariate analysis results did not show a significant correlation between Vitamin D levels and LDL-C (P=0.634). Furthermore, a nonlinear relationship was observed between Vitamin D levels and LDL-C by smooth curve fitting after adjusting for potential confounders. A multivariate piecewise linear regression model revealed a significant negative association between LDL-C and Vitamin D levels when LDL-C was greater than 3.1 mmol/L(β -2.9, 95% CI -5.4,-0.5; P=0.022). However, we did not observe a significant relationship between LDL-C and Vitamin D levels when LDL-C was lower than 3.1 mmol/L(β 2.4, 95% CI -0.2,5.1; P=0.076).Conclusions This study identified a nonlinear relationship between Vitamin D levels and LDL-C independent of other potential confounding factors, suggesting that the deficiency or insufficiency of Vitamin D in T1DM children with high LDL-C levels should be considered, especially LDL-C is higher than 3.1 mmol/L, which provides evidence of the timing about Vitamin D supplementation in T1DM children.

scholarly journals Effect of nutritional counseling on low-density lipoprotein cholesterol among Thai HIV-infected adults receiving antiretroviral therapy

AIDS Care ◽  
2015 ◽  
Vol 28 (2) ◽  
pp. 257-265 ◽  
Author(s):  
Saipin Chotivichien ◽  
Lenore Arab ◽  
Wisit Prasithsirikul ◽  
Weerawat Manosuthi ◽  
Sangsom Sinawat ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Nutritional Counseling

Which of low-density lipoprotein cholesterol estimates can be used in children with type 1 diabetes?

Diagnosis ◽  
2017 ◽  
Vol 4 (1) ◽  
pp. 43-50
Author(s):  
Jolanta Bugajska ◽  
Joanna Berska ◽  
Katarzyna Mamica ◽  
Karolina Wachacka ◽  
Krystyna Sztefko
Keyword(s):  
Type 1 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Medical Decision ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Serum Samples ◽  
Diabetic Children

AbstractBackground:One of the strongest risk factors of cardiovascular disease is a high concentration of low-density lipoprotein cholesterol (LDL-C); thus, the accurate measurement of LDL-C concentration in children is important. The aim of this study was to compare the concentration of LDL-C measured by direct method and the LDL-C concentration estimated by different formulas with the modified β-quantification method in children with type 1 diabetes.Methods:Thirty-one serum samples received from diabetic children (15/18; M/F) and 26 serum samples taken from nondiabetic children (18/14; M/F) were used in the study. LDL-C concentrations were determined by direct enzymatic method (LDL-CResults:The results of LDL-CConclusions:The limitations of methods measurement and of each of the formulas should be taken into account when a medical decision to lower LDL-C is made in the treatment of diabetic children.

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