Risk of tumor progression in colon carcinoma resection and perioperative prophylaxis with polyvalent immunoglobulins – per aspera ad astra

2018 ◽  
Vol 56 (02) ◽  
pp. 53-55
Author(s):  
Reinhard Lissner ◽  
Martin Gasser ◽  
Anna Waaga-Gasser ◽  
Barry Woodcock
Keyword(s):  
Tumor Progression ◽  
Colon Carcinoma ◽  
Perioperative Prophylaxis ◽  
Polyvalent Immunoglobulins

scholarly journals Tumor Necrosis Factor-α Stimulates the Epithelial-to-Mesenchymal Transition of Human Colonic Organoids

2003 ◽  
Vol 14 (5) ◽  
pp. 1790-1800 ◽  
Author(s):  
Richard C. Bates ◽  
Arthur M. Mercurio
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Progression ◽  
Colon Carcinoma ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Transforming Growth Factor ◽  
Mesenchymal Transition ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

An epithelial-mesenchymal transition (EMT) characterizes the progression of many carcinomas and it is linked to the acquisition of an invasive phenotype. Given that the tumor microenvironment is an active participant in tumor progression, an important issue is whether a reactive stroma can modulate this process. Using a novel EMT model of colon carcinoma spheroids, we demonstrate that their transforming-growth factor-β1 (TGF-β)-induced EMT is accelerated dramatically by the presence of activated macrophages, and we identify tumor necrosis factor-α (TNF-α) as the critical factor produced by macrophages that accelerates the EMT. A synergy of TNF-α and TGF-β signaling promotes a rapid morphological conversion of the highly organized colonic epithelium to dispersed cells with a mesenchymal phenotype, and this process is dependent on enhanced p38 MAPK activity. Moreover, exposure to TNF-α stimulates a rapid burst of ERK activation that results in the autocrine production of this cytokine by the tumor cells themselves. These results establish a novel role for the stroma in influencing EMT in colon carcinoma, and they identify a selective advantage to the stromal presence of infiltrating leukocytes in regulating malignant tumor progression.

scholarly journals p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase

2011 ◽  
Vol 71 (2) ◽  
pp. 360-370 ◽  
Author(s):  
Hong-Gang Yu ◽  
Ju-Ock Nam ◽  
Nichol L. G. Miller ◽  
Isabelle Tanjoni ◽  
Colin Walsh ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Focal Adhesion Kinase ◽  
Colon Carcinoma ◽  
Focal Adhesion ◽  
Carcinoma Tumor

Expressions of cyclooxygenase-2 (COX-2) and prostaglandin E receptors (EPs) in gallbladder carcinoma (GBca)-association with tumor progression

2001 ◽  
Vol 120 (5) ◽  
pp. A573-A573
Author(s):  
J SHODA ◽  
T ASANO ◽  
T KAWAMOTO ◽  
Y MATSUZAKI ◽  
N TANAKA ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Gallbladder Carcinoma ◽  
Cyclooxygenase 2 ◽  
Prostaglandin E ◽  
Cox 2

150: Inhibition of Tumor Progression Using Antisense Oligonucleotide Targeting GLI2 in Androgen Independent Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 51-51
Author(s):  
Shintaro Narita ◽  
Alan I. So ◽  
Shannon Sinnemann ◽  
Ladan Fazli ◽  
Eric G. Marcusson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Progression ◽  
Antisense Oligonucleotide ◽  
Androgen Independent
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