Intravenous proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: determining statistical equivalence according to evidence-based methods

2014 ◽  
Vol 52 (10) ◽  
pp. 825-829 ◽  
Author(s):  
Andrea Messori ◽  
Valeria Fadda ◽  
Dario Maratea ◽  
Roberta Gatto ◽  
Sabrina Trippoli ◽  
...  
Keyword(s):  
Critically Ill ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Critically Ill Patients ◽  
Stress Ulcer ◽  
Stress Ulcer Prophylaxis ◽  
Evidence Based ◽  
Statistical Equivalence ◽  
Ulcer Prophylaxis

Proton-Pump Inhibitors for Stress Ulcer Prophylaxis in Critically Ill Patients

2002 ◽  
Vol 36 (12) ◽  
pp. 1929-1937 ◽  
Author(s):  
Rose Jung ◽  
Robert MacLaren
Keyword(s):  
Critical Care ◽  
Critically Ill ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Critically Ill Patients ◽  
Comparative Studies ◽  
Stress Ulcer ◽  
Stress Ulcer Prophylaxis ◽  
Intragastric Ph ◽  
Ulcer Prophylaxis

OBJECTIVE: To evaluate the use of proton-pump inhibitors (PPIs) for stress ulcer prophylaxis in critically ill adults. DATA SOURCES: Computerized biomedical literature search of MEDLINE (1966–June 2002) was conducted using the MeSH headings proton-pump inhibitor, ulcer, critical care, and acid. References of selected articles were reviewed. A manual search of critical care, surgery, trauma, gastrointestinal, and pharmacy journals was conducted to identify relevant abstracts. DATA SYNTHESIS: Traditional medications used for stress ulcer prophylaxis include antacids, histamine2 receptor antagonists (H2RAs), and sucralfate. Few studies have evaluated PPIs for stress ulcer prophylaxis. The majority of studies have demonstrated that enteral or intravenous administration of PPIs to critically ill patients elevates intragastric pH and consistently maintains pH ≥4.0. PPIs are safe and seem to be as efficacious as H2RAs or sucralfate for prevention of bleeding from stress-related mucosal damage (SRMD) and they may provide cost minimization. The small patient populations limit the results of comparative studies. CONCLUSIONS: Available data indicate that PPIs are safe and efficacious for elevating intragastric pH in critically ill patients. PPIs should be used only as an alternative to H2RAs or sucralfate since the superiority of PPIs over these agents for preventing SRMD-associated gastrointestinal bleeding has not been established. Additional comparative studies with adequate patient numbers and pharmacoeconomic analyses are needed before PPIs are considered the agents of choice for stress ulcer prophylaxis.

Proton Pump Inhibitors Versus Histamine-2-Receptor Antagonists for Stress Ulcer Prophylaxis in Critically Ill Patients

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Smit S. Deliwala ◽  
Kewan Hamid ◽  
Hemant Goyal ◽  
Anoosha Ponnapalli ◽  
Yazan Zayed ◽  
...  
Keyword(s):  
Critically Ill ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Critically Ill Patients ◽  
Stress Ulcer ◽  
Stress Ulcer Prophylaxis ◽  
Receptor Antagonists ◽  
Ulcer Prophylaxis

Impact of a Multifaceted Intervention on Prescribing of Proton Pump Inhibitors for Stress Ulcer Prophylaxis in the Critically Ill

2015 ◽  
Vol 1 (2) ◽  
Author(s):  
Matthew Joseph Morrisette ◽  
John Michael Hammer ◽  
William Edward Anderson ◽  
Harry James Norton ◽  
Michael Brian Green ◽  
...  
Keyword(s):  
Critically Ill ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Stress Ulcer ◽  
Multifaceted Intervention ◽  
Stress Ulcer Prophylaxis ◽  
Ulcer Prophylaxis
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