The effect of experimentally induced sleep disturbance on the pharmacokinetics of lorazepam in healthy volunteers

2014 ◽  
Vol 52 (06) ◽  
pp. 519-524
Author(s):  
Tsutomu Kotegawa ◽  
Kimiko Tsutsumi ◽  
Hiromitsu Imai ◽  
Kyoichi Ohashi ◽  
Shigeyuki Nakano
Keyword(s):  
Sleep Disturbance ◽  
Healthy Volunteers ◽  
Experimentally Induced

scholarly journals 0275 Exposure to Experimentally Induced Sleep Disturbance Affects the Inflammatory Resolution Pathways in Healthy Humans

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A104-A105
Author(s):  
L C Engert ◽  
M Dubourdeau ◽  
J M Mullington ◽  
M Haack
Keyword(s):  
Sleep Disturbance ◽  
Sleep Disturbances ◽  
Sleep Onset ◽  
Experimental Studies ◽  
Low Grade ◽  
Omega 3 ◽  
Science Center ◽  
Healthy Humans ◽  
Recovery Sleep ◽  
Experimentally Induced

Abstract Introduction Sleep disturbances are assumed to impair health through induction of low-grade systemic inflammation. Experimental studies have shown that such inflammatory upregulation does not normalize even after a couple of nights of recovery sleep. We hypothesized that sleep disturbances do not only affect inflammatory pathways, but also the recently detected inflammatory resolution pathways, which actively terminate inflammation. Mediators of inflammatory resolution mainly derive from omega-3 fatty acids converted to specialized pro-resolving mediators (SPMs), such as resolvins. We investigated SPMs in healthy humans exposed to a novel model of experimental insomnia. Methods Twenty-four individuals (age 18–42 years, 12 women) participated in a study consisting of two 19-day in-hospital protocols (insomnia/control). After three nights of baseline sleep (8h/night, 23:00-07:00), participants in the experimental insomnia condition were exposed to three cycles of three nights of disturbed sleep (delayed sleep-onset, hourly sleep disruption, advanced sleep-offset) followed by one night of 8h-recovery sleep. The protocol ended with three additional nights of recovery sleep. In the control condition, participants had an uninterrupted sleep opportunity (8h/night) across the 19-day protocol. Blood samples were taken at 11:00 at baseline, during experimental insomnia exposure, and after recovery sleep. Several SPMs were measured in plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Data were analyzed using linear mixed models. Results Exposure to experimental insomnia affected several SPMs compared to control sleep, including a decrease of resolvin D4 and E2 concentrations, which was still evident after the third recovery night (p<.05). Conclusion This is the first investigation on the effects of experimentally induced sleep disturbance on inflammatory resolution pathways. The results support that SPMs, particularly resolvin D4 and E2, are decreased by sleep disturbances, and do not normalize after a couple of nights of recovery sleep. Targeting these pathways by pharmacologically increasing SPMs may help to limit inflammatory consequences of sleep disturbances. Support NIH/NINDS R01-NS091177; NIH/National Center for Research Resources UL1-RR02758 and M01-RR01032 to the Harvard Clinical and Translational Science Center.

scholarly journals Convergent neural representations of experimentally-induced acute pain in healthy volunteers: A large-scale fMRI meta-analysis

2020 ◽  
Vol 112 ◽  
pp. 300-323 ◽  
Author(s):  
Anna Xu ◽  
Bart Larsen ◽  
Erica B. Baller ◽  
J. Cobb Scott ◽  
Vaishnavi Sharma ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Acute Pain ◽  
Large Scale ◽  
Meta Analysis ◽  
Neural Representations ◽  
Experimentally Induced

scholarly journals Sceletium tortuosum (Zembrin ® ) ameliorates experimentally induced anxiety in healthy volunteers

2020 ◽  
Vol 35 (6) ◽  
pp. 1-7
Author(s):  
Jonathon Reay ◽  
Mark A. Wetherell ◽  
Emma Morton ◽  
James Lillis ◽  
Vladimir Badmaev
Keyword(s):  
Healthy Volunteers ◽  
Experimentally Induced

Dose-dependent effects of morphine on experimentally induced cutaneous pain in healthy volunteers

Pain ◽  
2005 ◽  
Vol 116 (3) ◽  
pp. 366-374 ◽  
Author(s):  
Helène Schulte ◽  
Alf Sollevi ◽  
Märta Segerdahl
Keyword(s):  
Healthy Volunteers ◽  
Cutaneous Pain ◽  
Dose Dependent ◽  
Experimentally Induced
Sign in / Sign up

Export Citation Format

Share Document