Adiponectin in chronic kidney disease has an opposite impact on protein-energy wasting and cardiovascular risk: two sides of the same coin

2009 ◽  
Vol 72 (08) ◽  
pp. 87-96 ◽  
Author(s):  
S.-H. Park ◽  
J.J. Carrero ◽  
B. Lindholm ◽  
P. Stenvinkel
Keyword(s):  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Protein Energy Wasting ◽  
Protein Energy ◽  
Two Sides

The role of inflammation in chronic kidney disease

2015 ◽  
Author(s):  
Juan Jesús Carrero ◽  
Peter Stenvinkel
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Endocrine Disorders ◽  
Low Grade ◽  
Protein Energy Wasting ◽  
Protein Levels ◽  
Reactive Protein ◽  
Protein Energy ◽  
Persistent Inflammation ◽  
Clinical Consequences

Low-grade persistent inflammation is a common feature of chronic kidney disease. This chapter provides an overview of the pathogenesis and clinical consequences of elevated pro-inflammatory cytokines in the uraemic milieu with an emphasis on dialysis stages. It reviews the multifactorial dialysis- and non-dialysis-related causes of inflammation and its purported role in the development of protein energy wasting, vascular calcification, endocrine disorders, and depression. The chapter also discusses the use and the need of monitoring C-reactive protein levels regularly in the clinical setting and comments on possible therapeutic approaches to reduce inflammation in these patients.

scholarly journals A Practical Approach to Nutrition, Protein-Energy Wasting, Sarcopenia, and Cachexia in Patients with Chronic Kidney Disease

2019 ◽  
Vol 49 (1-2) ◽  
pp. 202-211 ◽  
Author(s):  
Ramy M. Hanna ◽  
Lena Ghobry ◽  
Olivia Wassef ◽  
Connie M. Rhee ◽  
Kamyar Kalantar-Zadeh
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Disease ◽  
Caloric Intake ◽  
Nutritional Risk ◽  
Protein Energy Wasting ◽  
Dietary Counseling ◽  
Holistic View ◽  
Reverse Epidemiology ◽  
Protein Energy

Objectives of Review: Protein-energy wasting (PEW) is a state of disordered catabolism resulting from metabolic and nutritional derangements in chronic disease states. Patients with chronic kidney disease (CKD), and end-stage renal disease (ESRD) in particular, have muscle wasting, sarcopenia, and cachexia that contribute to frailty and morbidity. Moreover, reverse epidemiology findings have strongly linked PEW with mortality in CKD and ESRD. Updated Findings: The malnutrition-inflammation score (KALANTAR Score) provides a useful tool to predict nutritional risk. A stronger focus on renal nutrition in renal patients is needed to attenuate cachexia and muscle loss. Malnutrition is a far greater threat in patients with renal disease than obesity, which means dietary counseling needs to be tailored to reflect this observation. The need to achieve optimal caloric intake is compounded by the need to limit excess protein intake in CKD, resulting in the need for energy supplementation to avoid PEW. Preventing PEW is the most pressing clinical concern in CKD/ESRD. Other nutritional issues to reckon in renal disease include the need to normalize serum bicarbonate to manage acidosis, uric acid control, and phosphorous control in CKD and ESRD. Exercise maybe beneficial, but further work is needed to prove a conclusive benefit via a randomized trial. Summary: PEW prevention is an integral part of renal nutrition and is of paramount importance given the obesity paradox. Integrative approaches by physicians and dieticians are needed to take a holistic view of a patient’s diet beyond just control of particular laboratory parameters.

Features of pathogenetic mechanisms of protein-energy wasting development in patients with chronic kidney disease stage 5D

Nephrology ◽  
2020 ◽  
Vol 4_2020 ◽  
pp. 60-64
Author(s):  
A.S. Kuzyarovа Kuzyarovа ◽  
M.Z. Gasanov Gasanov ◽  
M.M. Batyushin Batyushin ◽  
K.R. Bogomolova Bogomolova ◽  
I.H. Adamokova Adamokova ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Protein Energy Wasting ◽  
Pathogenetic Mechanisms ◽  
Protein Energy
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