Evolution and predictive power of serum cystatin C in acute renal failure

2004 ◽  
Vol 62 (11) ◽  
pp. 344-350 ◽  
Author(s):  
A. Åhlström ◽  
M. Tallgren ◽  
S. Peltonen ◽  
V. Pettilä
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Cystatin C ◽  
Predictive Power ◽  
Serum Cystatin C ◽  
Serum Cystatin

Serum Cystatin C-A Useful Endogenous Marker of Renal Function in Intensive Care Unit Patients at Risk for or with Acute Renal Failure?

2007 ◽  
Vol 14 (21) ◽  
pp. 2314-2317 ◽  
Author(s):  
Annick A. Royakkers ◽  
Jeroen van Suijlen ◽  
Lieuwe Hofstra ◽  
Michael Kuiper ◽  
Catherine Bouman ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
At Risk ◽  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Intensive Care ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Patients At Risk

scholarly journals Early detection of acute renal failure by serum cystatin C

2004 ◽  
Vol 66 (3) ◽  
pp. 1115-1122 ◽  
Author(s):  
Stefan Herget-rosenTHAL ◽  
Günter Marggraf ◽  
Johannes Hüsing ◽  
Frauke Göring ◽  
Frank Pietruck ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Early Detection ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals The elevated serum urea : creatinine ratio in canine babesiosis in South Africa is not of renal origin

2006 ◽  
Vol 77 (4) ◽  
Author(s):  
M.P. De Scally ◽  
A.L. Leisewitz ◽  
R.G. Lobetti ◽  
P.N. Thompson
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Elevated Serum ◽  
Serum Urea ◽  
Canine Babesiosis ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Renal Origin

Pigmented serum, usually due to free haemoglobin and/or bilirubin, is a common finding in dogs with babesiosis, resulting in interference with all biochemical tests that rely on photochemistry. This is particularly true of urea and creatinine determinations, complicating the diagnosis of acute renal failure, which is a serious complication of babesiosis. A disproportionately raised serum urea concentration of unknown origin occurs in severely anaemic canine babesiosis patients and gives rise to an increased serum urea:creatinine ratio. The assay for cystatin-C, an excellent measure of glomerular filtration rate, is unaffected by free serum haemoglobin, and due to its different intrinsic origins, is free of influence by the metabolic derangements and organ pathology, other than renal disease, encountered in canine babesiosis. Serum cystatin-C was used to compare the concentrations of serum urea and serum creatinine in dogs with the severely anaemic form of canine babesiosis as well as a canine babesiosis-free reference group. Mean serum urea and mean serum urea:creatinine ratio were significantly elevated in the babesia-infected group relative to the reference population in this study. Mean serum creatinine and mean serum cystatin-C were within the reference ranges. Therefore an elevated urea:creatinine ratio in canine babesiosis in the presence of a normal serum creatinine concentration is considered to be caused by an elevated serum urea concentration and is most likely of non-renal origin. Serum creatinine was therefore as specific a measure of renal function as serum cystatin-C in canine babesiosis in this study. The sensitivity of serum creatinine as a measure of renal function was not established by this study. Serum urea, however, proved to be of little use compared to serum cystatin-C and serum creatinine. Serum urea should therefore not be used to diagnose renal failure in canine babesiosis.

scholarly journals Usefulness of Serum Cystatin C Measurement for Assessing Renal Function in Cats

2012 ◽  
Vol 56 (2) ◽  
pp. 235-239 ◽  
Author(s):  
Iwona Poświatowska-Kaszczyszyn
Keyword(s):  
Renal Failure ◽  
Serum Concentration ◽  
Renal Dysfunction ◽  
Cystatin C ◽  
High Performance ◽  
Characteristic Curve ◽  
Compartment Model ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Group I

Abstract The aim of the work was to determine the concentration of serum cystatin C and usability of its measurement in diagnostics of renal failure in cats. The reference point was the value of glomerular filtration rate (GFR), calculated on the basis of plasma clearance of iohexol (Pcio). Seventy cats were divided into two groups: group I - 24 healthy cats, group II - 46 cats affected with renal dysfunction. The measurement of serum cystatin C was done according to immunonefelometric method. In order to estimate Pcio, the following blood samples were collected: pre-sample - 0, and samples collected 120, 180, 240, and 300 min after intravenous administration of iohexol. Its concentration was determined using high performance liquid chromatography. Pcio was obtained using a one-compartment model, according to the method developed by Krutzen Back and Nilsson-Ehl. Serum concentration of cystatin C in cats with renal dysfunction was significantly statistically higher (1.3 ± 0.6 mg/L) as compared to the group of healthy animals (0.7 ± 0.2 mg/L). Statistical analysis of the data confirmed strong correlation between GFR and serum concentration of cystatin C (r = - 0.51). Data analysis on the basis of the receiver operating characteristic curve proved that cystatin C seems to be more reliable parameter than creatinine in the assessment of kidneys function in cats and the measurement of cystatin C in blood serum can be of a considerable meaning as far as early diagnosis of renal failure in cats is concerned.

Predictive power of serum cystatin C to detect acute kidney injury and pediatric-modified RIFLE class in children undergoing cardiac surgery*

2012 ◽  
Vol 13 (4) ◽  
pp. 435-440 ◽  
Author(s):  
Amanda B. Hassinger ◽  
Carl L. Backer ◽  
Jerome C. Lane ◽  
Shannon Haymond ◽  
Deli Wang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cystatin C ◽  
Predictive Power ◽  
Kidney Injury ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Cystatin C as a marker for detection of early renal failure in diabetes type 2 patients

2005 ◽  
Vol 5 (4) ◽  
pp. 68-71
Author(s):  
Belma Aščić - Buturović ◽  
Semra Čavaljuga
Keyword(s):  
Renal Failure ◽  
Cystatin C ◽  
Screening Test ◽  
Metabolic Diseases ◽  
Diabetes Type 2 ◽  
Epidemiological Studies ◽  
Diabetes Type ◽  
Serum Cystatin C ◽  
Serum Cystatin

The epidemiological studies have show dramatic increase and prevalence of end stage renal disease in patients with type 2 diabetes therefore early markers of diabetic nephropathy need to be identified (1). During the treatment of patients at the Clinic of endocrinology, diabetes mellitus and metabolic diseases in Sarajevo, we observed a necessity of application of new markers in assessment of early renal failure. Serum cystatin C level is another marker of renal function. Cystatin C is freely filtered at the level of the glomerulus and virtually all is re-absorbed and metabolized by the proximal tubular cells. Serum cystatin C is a screening test and an early indicator and predictor of the development of renal failure.AIM OF THE STUDY:To estimate correlation among cystatin C, serum creatinine and albuminuria in diabetes type 2 patients for assessment of early renal failure. Serum cystatin C as a screening test has to be considered in the treatment of diabetes type 2 patients for assessment of early renal failure.

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