The effects of dual blockade of the renin- angiotensin system on urinary protein and transforming growth factor-b excretion in 2 groups of patients with IgA and diabetic nephropathy

2003 ◽  
Vol 60 (11) ◽  
pp. 318-326 ◽  
Author(s):  
J.H. Song ◽  
S.W. Lee ◽  
J.H. Suh ◽  
E.S. Kim ◽  
S.B. Hong ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Renin Angiotensin System ◽  
Urinary Protein ◽  
Factor B ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Dual Blockade

scholarly journals Renal Kallikrein Activation and Renoprotection after Dual Blockade of Renin-Angiotensin System in Diet-Induced Diabetic Nephropathy

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Xia Zou ◽  
Xiao-xi Zhang ◽  
Xin-yu Liu ◽  
Rong Li ◽  
Min Wang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Inflammatory Response ◽  
Transforming Growth Factor ◽  
Combined Treatment ◽  
Renin Angiotensin System ◽  
Functional Impairments ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Renal Kallikrein ◽  
Dual Blockade

Purpose. The objective of this study is to investigate the effect of dual blockage of renin-angiotensin system (RAS) on renal kallikrein expression and inflammatory response in diabetic nephropathy (DN).Methods. Rats were randomly divided into 5 groups with 10 rats in each group: normal control; DN model induced by high fat and high sucrose diets; and DN treated with either benazepril 10 mg/kg/d, irbesartan 30 mg/kg/d, or both. After 8-week treatment, we examined changes in the kidney histopathology, function and immunohistochemical stain of kallikrein, macrophage marker CD68, and profibrotic markers transforming growth factor- (TGF-)βandα-smooth muscle action (SMA).Results. DN rats showed enlarged kidneys with glomerulosclerosis, interstitial chronic inflammation and fibrosis, and proteinuria. All the pathological damage and functional impairments were improved after the RAS blockades (allP<0.05). Compared with monotherapy, combined treatment further alleviated the kidney impairments in parallel to increased tubular immunoreactivity for kallikrein and decreased immunopositive cells for CD68, TGF-β, andα-SMA.Conclusion. The renoprotective effects of the dual RAS blockade in diabetic nephropathy may be attributed to improved tubular kallikrein expression and interstitial inflammatory response.

Disputes in the Treatment of Diabetic Nephropathy: The Dual Blockade of Renin-Angiotensin System

2016 ◽  
Vol 124 (06) ◽  
pp. 361-366
Author(s):  
E. Grolla ◽  
L. Bonanni ◽  
A. Cutolo ◽  
F. Presotto ◽  
M. Dalla Vestra
Keyword(s):  
Diabetic Nephropathy ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Dual Blockade
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