scholarly journals Successful eculizumab treatment of recurrent postpartum atypical hemolytic uremic syndrome after kidney transplantation

2015 ◽  
Author(s):  
Katherine Garlo ◽  
Doug Dressel ◽  
Marizela Savic ◽  
John Vella
Keyword(s):  
Kidney Transplantation ◽  
Hemolytic Uremic Syndrome ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Uremic Syndrome

Atypical hemolytic uremic syndrome diagnosed four years after ABO-incompatible kidney transplantation

Nephrology ◽  
2015 ◽  
Vol 20 ◽  
pp. 61-65 ◽  
Author(s):  
Keiko Kawaguchi ◽  
Kunio Kawanishi ◽  
Masayo Sato ◽  
Mitsuyo Itabashi ◽  
Akiko Fujii ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Hemolytic Uremic Syndrome ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Uremic Syndrome

SP005PREVENTIVE PLASMA THERAPY FOR PREVENTION OF ATYPICAL HEMOLYTIC UREMIC SYNDROME RELAPSE FOLLOWING KIDNEY TRANSPLANTATION

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Christof Aigner ◽  
Georg A Böhmig ◽  
Farsad Eskandary ◽  
Harald Herkner ◽  
Zoltán Prohászka ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Hemolytic Uremic Syndrome ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Plasma Therapy ◽  
Uremic Syndrome

Atypical Hemolytic Uremic Syndrome Recurrence After Kidney Transplantation

2014 ◽  
Vol 98 (11) ◽  
pp. 1205-1212 ◽  
Author(s):  
Dany Matar ◽  
Fizza Naqvi ◽  
Lorraine C. Racusen ◽  
Naima Carter-Monroe ◽  
Robert A. Montgomery ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Hemolytic Uremic Syndrome ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Uremic Syndrome

Long-term successful liver–kidney transplantation in a child with atypical hemolytic uremic syndrome caused by homozygous factor H deficiency

2016 ◽  
Vol 31 (12) ◽  
pp. 2375-2378 ◽  
Author(s):  
Emmanuel Gonzales ◽  
Tim Ulinski ◽  
Dalila Habes ◽  
Georges Deschênes ◽  
Véronique Frémeaux-Bacchi ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Hemolytic Uremic Syndrome ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Factor H ◽  
Factor H Deficiency ◽  
Uremic Syndrome

Interdisciplinary Expert Council Resolution. Kidney transplantation in patients with atypical hemolytic-uremic syndrome: clinical and organizational-methodical aspects of patient management

Nephrology ◽  
2018 ◽  
Vol 3_2018 ◽  
pp. 8-14
Author(s):  
M.M. Kaabak Kaabak ◽  
E.A. Molchanova Molchanova ◽  
I.V. Nesterenko Nesterenko ◽  
A.V. Pinchuk Pinchuk ◽  
E.I. Prokopenko Prokopenko ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Hemolytic Uremic Syndrome ◽  
Patient Management ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Uremic Syndrome

scholarly journals Kidney transplantation using complement inhibitor in a patient suffering from atypical hemolytic-uremic syndrome associated with factor H antibodies: successful prevention of recurrence of the underlying disease

2020 ◽  
Vol 22 (2) ◽  
pp. 132-138
Author(s):  
E. I. Prokopenko ◽  
S. A. Pasov ◽  
A. V. Vatazin ◽  
A. Ya. Tsalman ◽  
T. E. Pankratenko ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Hemolytic Uremic Syndrome ◽  
Complement Activation ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Underlying Disease ◽  
Factor H ◽  
Inhibitor Therapy ◽  
Complement Inhibitor ◽  
Post Transplant ◽  
Uremic Syndrome

Atypical hemolytic-uremic syndrome (aHUS) is an extremely rare complement-mediated disease that belongs to the group of thrombotic microangiopathies (TMA). It often reoccurs after kidney transplantation (KT). Previously, KT was considered contraindicated in both children and adults with aHUS due to high (up to 50% and above) incidence of early graft loss associated with post-transplant recurrent TMA. Introduction of specific complement inhibitor therapy into clinical practice has improved outcomes in patients with aHUS and has significantly reduced the risk of post-transplant recurrence of underlying disease. We describe the clinical observation of a 20-year-old female patient with aHUS associated with antibodies to factor H, a major regulator of complement activation. The patient underwent KT and eculizumab was used for prophylactic purposes. In the postoperative period, the patient developed ureteral necrosis that required reconstructive surgery, followed by graft pyelonephritis. Despite postoperative complications, which were highly likely to trigger uncontrolled complement activation, TMA recurrence was avoided due to early treatment of the complications and prophylactic use of complement inhibitor therapy.

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