Retrospective single-arm cohort study of steroid-dependent minimal change nephrotic syndrome treated with very low-dose rituximab

2021 ◽  
Vol 95 (1) ◽  
pp. 29-36
Author(s):  
Keiji Fujimoto ◽  
Yu Kagaya ◽  
Syo Kumano ◽  
Ai Fujii ◽  
Yuko Tsuruyama ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cohort Study ◽  
Low Dose ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Steroid Dependent

scholarly journals Efficacy of Semiannual Single Fixed Low-Dose Rituximab Therapy in Steroid-Dependent Minimal Change Nephrotic Syndrome: A Case Series

2018 ◽  
Vol 8 (3) ◽  
pp. 230-237 ◽  
Author(s):  
Ryosuke Usui ◽  
Yohei Tsuchiya ◽  
Kosaku Nitta ◽  
Minako Koike
Keyword(s):  
Nephrotic Syndrome ◽  
Low Dose ◽  
Chemotherapy Regimen ◽  
Case Series ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Cell Hyperplasia ◽  
Conventional Dose ◽  
Steroid Dependent ◽  
Refractory Nephrotic Syndrome

The frequency of using rituximab to treat refractory nephrotic syndrome has recently been increasing, and the conventional dose of rituximab used to treat it, 375 mg/m2 body surface area once weekly for 4 weeks, has been modelled on the chemotherapy regimen for B-cell non-Hodgkin’s lymphoma. The dose and intervals of rituximab in refractory nephrotic syndrome remain controversial. Clear lymphoma cell hyperplasia is seen in lymphoma patients, but not in nephrotic syndrome patients. Since we thought that it might be possible to reduce the dose of rituximab if only used for the purpose of depleting CD20-positive B cells in nephrotic patients’ peripheral blood, we tried semiannually with a single fixed rituximab dose of 100 mg/body, and a complete remission was attained in 3 cases without treatment with prednisolone or cyclosporine. Our report strongly suggests considering appropriate dose and interval of rituximab therapy in the treatment of steroid-dependent nephrotic syndrome.

scholarly journals Effect of single-dose rituximab on steroid-dependent minimal-change nephrotic syndrome in adults

2012 ◽  
Vol 28 (5) ◽  
pp. 1225-1232 ◽  
Author(s):  
T. Takei ◽  
M. Itabashi ◽  
T. Moriyama ◽  
C. Kojima ◽  
S. Shiohira ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Single Dose ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Steroid Dependent

scholarly journals Favorable Outcome of Low-dose Cyclosporine after Pulse Methylprednisolone in Japanese Adult Minimal-change Nephrotic Syndrome

2004 ◽  
Vol 43 (8) ◽  
pp. 668-673 ◽  
Author(s):  
Hiroshi MATSUMOTO ◽  
Toshiyuki NAKAO ◽  
Tomonari OKADA ◽  
Yume NAGAOKA ◽  
Fumihiro TAKEGUCHI ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Low Dose ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Favorable Outcome ◽  
Japanese Adult ◽  
Pulse Methylprednisolone

scholarly journals Controlled trial of methylprednisolone pulses and low dose oral prednisone for the minimal change nephrotic syndrome.

BMJ ◽  
1985 ◽  
Vol 291 (6505) ◽  
pp. 1305-1308 ◽  
Author(s):  
E Imbasciati ◽  
R Gusmano ◽  
A Edefonti ◽  
P Zucchelli ◽  
C Pozzi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Low Dose ◽  
Controlled Trial ◽  
Oral Prednisone ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Dose Oral

scholarly journals Complete remission induced by tacrolimus and low-dose prednisolone in adult minimal change nephrotic syndrome: A pilot study

2012 ◽  
Vol 31 (2) ◽  
pp. 112-117 ◽  
Author(s):  
Yong Chul Kim ◽  
Tae Woo Lee ◽  
Hajeong Lee ◽  
Ho Suk Koo ◽  
Kook-Hwan Oh ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Pilot Study ◽  
Complete Remission ◽  
Low Dose ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change
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