The unresolved epidemic of chronic kidney disease of uncertain origin (CKDu) around the world: A review and new insights

2020 ◽  
Author(s):  
Vito M. Campese
PRILOZI ◽  
2016 ◽  
Vol 37 (1) ◽  
pp. 9-13
Author(s):  
Velibor Tasic ◽  
Aleksandra Janchevska ◽  
Nora Emini ◽  
Emilija Sahpazova ◽  
Zoran Gucev ◽  
...  

Abstract The knowledge about the progression of chronic kidney disease is an important issue for every pediatric nephrologist and pediatrician in order to implement appropriate measures to prevent wasting of renal function and the final consequence – end stage renal disease with the need for the dialysis and transplantation. Therefore it is important to know, treat or ameliorate the standard risk factors such as hypertension, proteinuria, anemia, hyperparathyroidism etc. In this review devoted to the World Kidney Day 2016 we will pay attention to the low birth parameters, obesity, hyperuricemia and smoking which emerged as particularly important risk factors for children and adolescent with chronic kidney disease.


RSC Advances ◽  
2018 ◽  
Vol 8 (39) ◽  
pp. 21816-21822 ◽  
Author(s):  
Hongling Yang ◽  
Shukun Wu

Diabetic nephropathy (DN) is a major cause of chronic kidney disease around the world.


The number of patients with advanced kidney disease requiring dialysis is increasing in all parts of the world. Managing patients as they transition onto dialysis and providing support and guidance as they make important treatment choices are essential components of a nephrologist’s job. Ensuring timely preparation for dialysis, allowing patients the opportunity to explore all options, including conservative care, and managing individual expectations of dialysis are increasingly important. All nephrologists will manage patients treated with dialysis and therefore it is imperative that they have a sound understanding of different dialysis modalities, how to assess the adequacy of dialysis, and the commonly encountered medical problems dialysis patients experience.


2016 ◽  
Vol 4 (5) ◽  
pp. e307-e319 ◽  
Author(s):  
Bogdan Ene-Iordache ◽  
Norberto Perico ◽  
Boris Bikbov ◽  
Sergio Carminati ◽  
Andrea Remuzzi ◽  
...  

2017 ◽  
Vol 104 (1) ◽  
pp. 1-14 ◽  
Author(s):  
CP Kovesdy ◽  
S Furth ◽  
C Zoccali ◽  

Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term. The incidence of obesity-related glomerulopathy has increased tenfold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle, and health policy measures that makes preventive behaviors an affordable option.


2020 ◽  
pp. 14-15
Author(s):  
Bhanu Pratap Singh ◽  
Chhaju Ram Yadav

Chronic kidney disease is progressive forms of renal disorders associated with reduced renal function having no well known etio-pathogenesis. The conventional approach of management includes dialysis and renal transplantation, which are involving the high costs and complexity so very few patients are able to obtain adequate treatment for kidney disorders because of financial limitation. Therefore, exploration of a safe and alternative therapy is needed, which proves to be helpful in reducing the requirement of dialysis and in postponing the renal transplantation. The use of herbal drugs for the prevention and treatment of various diseases is constantly developing throughout the world. The present case is totally treated through Ayurvedic approach and it seems to be effective and safe.


2020 ◽  
Vol 23 (1) ◽  
Author(s):  
Anthony Were

COVID-19, a disease caused by the novel virus SARS-CoV-2, was declared a pandemic by the World Health Organization on 11 March 2020. It originated from Wuhan, the capital city of the Hubei province in central China. It has now spread to almost every country in the world and all the continents except Antarctica and has been associated with significant fatalities.COVID-19 infection has been documented in 47 countries in Africa, with almost 85,000 cases and 2,760 deaths as at 16 May 2020. The mortality is significantly lower in Africa than elsewhere for reasons that are still unclear. In the typical case, a patient presents with fever or respiratory symptoms such as cough or difficulty in breathing, usually within 14 days of coming into contact with an infected person. Acute kidney injury may occur as part of multisystem involvement in the very ill patient and is often managed in the intensive care unit. Our patients with chronic kidney disease, including those on chronic dialysis, will easily get infected with SARS-CoV-2 if exposed, due to their immunosuppressed state. Similarly, the immunosuppressed patient who has received a kidney transplant requires special precautions to prevent and manage infection with SARS-CoV-2. The transplantation operation itself also requires clear guidelines to prevent coronavirus infection.The executive committee of the African Association of Nephrology (AFRAN) convened a special project committee of senior nephrologists from across the continent to develop guidelines relevant to the African continent on the management of the renal complications of COVID-19 and on the management of COVID-19 in patients with chronic kidney disease. The guidelines include recommendations on the prevention and management of COVID-19 in patients receiving kidney replacement therapy with haemodialysis, peritoneal dialysis or a kidney transplant. The article, titled ‘Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa’, is published on page 109 of this issue and represents an impressive collaboration by African nephrologists. These guidelines will be of practical value across the length and breadth of the African continent, from the well resourced to the most disadvantaged settings. The guidelines will also be of value to other parts of the world with respect to COVID-19 and the kidney. On behalf of AFRAN, I wish to congratulate the colleagues who contributed to the development of these guidelines. We are sure that the information they contain will greatly benefit the management of COVID-19 in Africa. Anthony WerePresident, African Association of Nephrology.


The form of Chronic Kidney Disease (CKD) with a lacking known cause of origin unlike most other forms is said to be CKD of Unknown aetiology (CKDu). This condition has been often reported from tropical and subtropical countries around the world, specially, including Asian countries like Japan from where CKDu was first reported; and shows a growing risk of spreading around the world. Due to the absence of early signs and symptoms, CKDu is not diagnosed up until it reaches an irreversible state. Researches are being carried out to find the aetiology of the disease to help patients with better prognosis. Those have been able to put forward several hypotheses including hot climate, agricultural economy, hard water, heavy metals, microbial toxins, infectious diseases and genetic predisposition as the CKDu causatives. Also these researches have paved to identify more similarities and few differences between the CKDu cases reported from different countries. With the main aim to identify the epidemiology of CKDu in Asia, this article has been written with the intension of looking the similarities and differences of CKDu found in Asian countries. Already published primary and review articles have been studied and summarized in this article to present a review on epidemiology of CKDu in Asia.


2017 ◽  
Vol 21 (2) ◽  
pp. 10-19
Author(s):  
Csaba P. Kovesdy ◽  
Susan Furth ◽  
Carmine Zoccali

on behalf of the World Kidney Day Steering Committee. Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for Chronic Kidney Disease. A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing Chronic Kidney Disease in the long-term. The incidence of obesity-related glomerulopathy has increased ten-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that makes preventive behaviors an affordable option.


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