The importance of correct estimation of renal function for drug treatment in hospitalized elderly patients, especially women: A prospective observational study

2019 ◽  
Vol 91 (4) ◽  
pp. 254-264 ◽  
Author(s):  
Anders Helldén ◽  
Ulf Bergman ◽  
Ingegerd Odar-Cederlöf
Keyword(s):  
Renal Function ◽  
Observational Study ◽  
Elderly Patients ◽  
Drug Treatment ◽  
Prospective Observational Study ◽  
Hospitalized Elderly ◽  
Hospitalized Elderly Patients ◽  
Correct Estimation

Seasonal influence on the renal function in hospitalized elderly patients

2015 ◽  
Vol 6 (3) ◽  
pp. 232-236 ◽  
Author(s):  
L. Barski ◽  
C. Bartal ◽  
I. Sagy ◽  
A. Jotkowitz ◽  
R. Nevzorov ◽  
...  
Keyword(s):  
Renal Function ◽  
Elderly Patients ◽  
Seasonal Influence ◽  
Hospitalized Elderly ◽  
Hospitalized Elderly Patients

scholarly journals Should we still monitor QTc duration in frail older patients on low-dose haloperidol? A prospective observational cohort study

2020 ◽  
Vol 49 (5) ◽  
pp. 829-836
Author(s):  
Ellen Castro ◽  
Frank Körver ◽  
Audrey Merry ◽  
Fieke van Moorsel ◽  
Mark Hazebroek ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Prospective Observational Study ◽  
Low Dose ◽  
Frailty Index ◽  
Control Group ◽  
Average Dose ◽  
Hospitalized Elderly ◽  
Observational Cohort ◽  
Hospitalized Elderly Patients ◽  
Haloperidol Group

Abstract Background Haloperidol at high dosage is associated with QTc prolongation and polymorphic ventricular arrhythmia but the effects of low-dose haloperidol remain unknown. Objective To evaluate the effects of low-dose haloperidol on QTc-duration in frail hospitalized elderly patients with delirium. Methods A prospective observational study including hospitalized patients aged ≥70 years with Groningen Frailty Index-score > 3. We included 150 patients who received haloperidol and 150 age- and frailty-matched control patients. Serial ECG recordings were performed at hospital admission and during hospitalization. QT-interval was corrected according to Framingham (QTc). Patients were grouped according to baseline QTc in normal (nQTc), borderline (bQTc) or abnormal (aQTc). Primary outcome was change in QTc-duration between first and second ECG. Potentially dangerous QTc was defined as QTc >500 ms or an increase of >50 ms. Results Patients in the haloperidol group (48% male, mean age 85y, nQT n = 98, bQT n = 31, aQT n = 20) received an average dose of 1.5 mg haloperidol per 24 hours. QTc decreased in patients with borderline (mean − 15 ± 29 ms, P < 0.05) or abnormal (−19 ± 27 ms, P < 0.05) QTc at baseline, no patients developed dangerous QTc-duration. In the control group (41% male, mean age 84y, nQT n = 99 bQT n = 29, aQT n = 22) QTc decreased to a similar extent (bQT −7 ± 16 ms, aQTc −23 ± 20 ms). Conclusion A trend to QTc shortening was seen, especially in patients with borderline or abnormal QTc at baseline, regardless of haloperidol use. These findings suggest that ECG monitoring of frail elderly patients who receive low-dose haloperidol, may not be necessary.

Analysis of prognosis in hospitalized elderly patients with pneumonia according to age groups

2017 ◽  
Vol 21 (3) ◽  
pp. 109-117
Author(s):  
Ayşegül Albay ◽  
Bengü Şaylan ◽  
Hacer Sali Çakır ◽  
Sema Basat
Keyword(s):  
Elderly Patients ◽  
Age Groups ◽  
Hospitalized Elderly ◽  
Hospitalized Elderly Patients

scholarly journals Safety of High-Dose Dabigatran in Elderly and Younger Patients with a Low Bleeding Risk: A Prospective Observational Study

Cardiology ◽  
2021 ◽  
pp. 1-5
Author(s):  
Aharon Erez ◽  
Gregory Golovchiner ◽  
Robert Klempfner ◽  
Ehud Kadmon ◽  
Gustavo Ruben Goldenberg ◽  
...  
Keyword(s):  
Observational Study ◽  
Elderly Patients ◽  
Prospective Observational Study ◽  
Bleeding Risk ◽  
The Elderly ◽  
High Dose ◽  
World Population ◽  
Younger Patients ◽  
End Point

<b><i>Introduction:</i></b> In patients with atrial fibrillation (AF) at risk for stroke, dabigatran 150 mg twice a day (DE150) is superior to warfarin for stroke prevention. However, there is paucity of data with respect to bleeding risk at this dose in elderly patients (≥75 years). We aimed to evaluate the safety of DE150 in comparison to warfarin in a real-world population with AF and low bleeding risk (HAS-BLED score ≤2). <b><i>Methods:</i></b> In this prospective observational study, 754 consecutive patients with AF and HAS-BLED score ≤2 were included. We compared outcome of elderly patients (age ≥75 tears) to younger patients (age &#x3c;75 years). The primary end point was the combined incidence of all-cause mortality, stroke, systemic emboli, and major bleeding event during a mean follow-up of 1 year. <b><i>Results:</i></b> There were 230 (30%) elderly patients, 151 patients were treated with warfarin, and 79 were treated with DE150. Fifty-two patients experienced the primary endpoint during the 1-year follow-up. Among the elderly, at 1-year of follow-up, the cumulative event rate of the combined endpoint in the DE150 and warfarin was 8.9 and 15.9% respectively (<i>p</i> = 0.14). After adjustment for age and gender, patients who were treated with DE150 had a nonsignificant difference in the risk for the combined end point as patients treated with warfarin both among the elderly and among the younger population (HR 0.58, 95% C.I = 0.25–1.39 and HR = 1.12, 95% C.I 0.62–2.00, respectively [<i>p</i> for age-group-by-treatment interaction = 0.83). <b><i>Conclusions:</i></b> Our results suggest that Dabigatran 150 mg twice a day can be safely used among elderly AF patients with low bleeding risk.

scholarly journals The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Takahisa Handa ◽  
Akinobu Nakamura ◽  
Aika Miya ◽  
Hiroshi Nomoto ◽  
Hiraku Kameda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Observational Study ◽  
Elderly Patients ◽  
Prospective Observational Study ◽  
Multivariate Logistic Regression Analysis ◽  
Glycemic Variability ◽  
Multivariate Logistic Regression

Abstract Background This study aimed to explore predictive factors of time below target glucose range (TBR) ≥ 1% among patients’ characteristics and glycemic variability (GV) indices using continuous glucose monitoring data in elderly patients with type 2 diabetes. Methods We conducted a prospective observational study on 179 (71 female) Japanese outpatients with type 2 diabetes aged ≥ 65 years. The characteristics of the participants with TBR ≥ 1% were evaluated by multivariate logistic regression analysis. Receiver-operating characteristic (ROC) curve analyses of GV indices, comprising coefficient of variation (CV), standard deviation, and mean amplitude of glycemic excursions, were performed to identify the optimal index for the identification of patients with TBR ≥ 1%. Results In the multivariate logistic regression analysis, none of the clinical characteristics, including HbA1c and C-peptide index, were independent markers for TBR ≥ 1%, while all three GV indices showed significant associations with TBR ≥ 1%. Among the three GV indices, CV showed the best performance based on the area under the curve in the ROC curve analyses. Conclusions Among elderly patients with type 2 diabetes, CV reflected TBR ≥ 1% most appropriately among the GV indices examined. Trial registration UMIN-CTR: UMIN000029993. Registered 16 November 2017

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