Analysis of circulating lncRNA expression profiles in patients with diabetes mellitus and diabetic nephropathy: Differential expression profile of circulating lncRNA

2019 ◽  
Vol 92 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Ying Yang ◽  
Xiaomeng Lv ◽  
Qiuling Fan ◽  
Xu Wang ◽  
Li Xu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Differential Expression ◽  
Expression Profile ◽  
Expression Profiles ◽  
Lncrna Expression ◽  
Patients With Diabetes ◽  
Differential Expression Profile

Differential expression profile analysis of PSTK‐regulated mRNAs in podocytes

2019 ◽  
Vol 120 (6) ◽  
pp. 8935-8948
Author(s):  
Dong Zheng ◽  
Ying Zhao ◽  
Limin Liu ◽  
Xiaodong Sun ◽  
Yiyuan Xia ◽  
...  
Keyword(s):  
Differential Expression ◽  
Expression Profile ◽  
Profile Analysis ◽  
Expression Profile Analysis ◽  
Differential Expression Profile

scholarly journals ASSESSMENT OF NEPHRIN AND PODOCIN LEVELS IN THE URINE OF PATIENTS WITH DIABETES MELLITUS

2017 ◽  
Vol 21 (2) ◽  
pp. 33-40
Author(s):  
I. N. Bobkova ◽  
A. A. Shchukina ◽  
M. V. Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Arterial Hypertension ◽  
Healthy Subjects ◽  
Early Diagnostics ◽  
Urinary Levels ◽  
Patients With Diabetes ◽  
Early Diabetic Nephropathy

THE AIM:to assess excretion value of podocytes injury biomarkers in urine and to clarify their significance for early diabetic nephropathy (DN) diagnostics in diabetes mellitus (DM) patients with different severity of albuminuria (AU)/proteinuria(PU).PATIENTS AND METHODS.74 DM pts were studied, including 30 with type1 DM (T1DM) and 44 pts with type2 DM (T2DM). They were divided into three groups: 41 pts with AU <30 mg/gCr (A1), 13 pts with AU 30-300 mg/gCr (A2), 20 pts with PU (A3). CKD S1 was revealed in 41pts, CKD S2 – in 25 pts, CKD S3 – in 8 pts. Arterial hypertension was observed in 52 pts of 74(70%), mainly in T2DM. 10 healthy subjects were studied as control. Urinary levels of nephrin and podocin (an important slit diaphragm proteins) were measured by ELISA.RESULTS.Nephrinuria (NU) >5,84ng/ml/g, which not detecting in controls, was revealed in 63% of A1 pts, in 77% – in A2, in 80% – in A3. Podocinuria (PdU)>1,73ng/ml/g was revealed in 78% of A1 pts, in 54% of A2 and in 83% – A3. NU in pts with PU was significantly higher than in AU<30 mg/g. PDU in groups with different AU/PU was equally high and has no differ between DM types. Direct correlation was obtained between NU and AU (R=0,947 p<0,05). NU and PdU in T1DM correlated directly with serum creatinine (R=0,489 p<0,05 and R=0,468 p<0,05) and indirectly with GFR (R=-0,461 p<0,05 and R=-0,36 р<0,05). In DM duration less than 5 years NU directly correlated with НbА1с level, in T2DM – indirectly with systolic blood pressure.CONCLUSON. Nephrin and podocin levels can be useful for early diagnostics and monitoring of DN. 

Differential expression profile of long non-coding RNAs in human thoracic aortic aneurysm

2018 ◽  
Vol 119 (10) ◽  
pp. 7991-7997 ◽  
Author(s):  
Yang Li ◽  
Yang Liu ◽  
Suxuan Liu ◽  
Feng Wu ◽  
Songhua Li ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Differential Expression ◽  
Expression Profile ◽  
Thoracic Aortic Aneurysm ◽  
Differential Expression Profile ◽  
Non Coding Rnas
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