Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients

2016 ◽  
Vol 86 (11) ◽  
pp. 229-235 ◽  
Author(s):  
Daijo Inaguma ◽  
Hibiki Shinjo ◽  
Akihito Tanaka ◽  
Eri Ito ◽  
Naoki Kamegai ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Left Atrial ◽  
Left Atrial Diameter ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D

scholarly journals Left Atrial Diameter and Albumin with Renal Outcomes in Chronic Kidney Disease

2013 ◽  
Vol 10 (5) ◽  
pp. 575-584 ◽  
Author(s):  
Szu-Chia Chen ◽  
Jer-Ming Chang ◽  
Yi-Chun Tsai ◽  
Jiun-Chi Huang ◽  
Ho-Ming Su ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Left Atrial ◽  
Left Atrial Diameter ◽  
Renal Outcomes

Relationship between serum 1,25-dihydroxyvitamin D and mortality in patients with pre-dialysis chronic kidney disease

2008 ◽  
Vol 12 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Daijo Inaguma ◽  
Hiroshi Nagaya ◽  
Kazuhiro Hara ◽  
Miho Tatematsu ◽  
Hibiki Shinjo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D

scholarly journals The Calcium/Phosphorus Homeostasis in Chronic Kidney Disease: From Clinical Epidemiology to Pathophysiology

2017 ◽  
Vol 30 (6) ◽  
pp. 485 ◽  
Author(s):  
Ana Pires ◽  
Luis Sobrinho ◽  
Hugo Gil Ferreira
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clinical Data ◽  
Serum Concentrations ◽  
Set Point ◽  
Pathophysiological Mechanisms ◽  
Dihydroxyvitamin D ◽  
Metabolism Regulation ◽  
1,25 Dihydroxyvitamin D ◽  
Calcium Phosphorus

Introduction: A simple data filtering process together with some basic concepts of control theory applied to electronically stored clinical data were used to identify some of the pathophysiological mechanisms underlying the perturbations of the calcium/phosphorus homeostasis in chronic kidney disease.Material and Methods: Retrospective data (a set per patient of serum single value concentrations of creatinine, calcium, phosphorus, parathormone, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D) from 2507 patients with stable chronic kidney disease not on renal replacement therapy were studied. The variables were paired and subjected sequentially to a moving average and partioned into frequency classes. The plots were interpreted using the concept of a feedback loop comprising two branches of opposite sign and of set point of the loop. The set point for each pair of variables is displaced in the course of the disease and this displacement indicates which of the two factors involved (the serum concentrations of calcium or parathormone, for example) is primarily affected.Results: This analysis showed that in the course of the development of chronic kidney disease the relationships between the observed variables progressed following a monotonous, a biphasic or a triphasic pattern.Discussion: As chronic kidney disease progresses, calcium/phosphorus metabolism regulation evolves through different phases. Later, there is a progressive loss of the parathyroid gland sensitivity to the control by the serum concentrations of calcium and phosphorus. The sensitivity to the inhibitory action of 1,25-dihydroxyvitamin D decreases monotonously but never releases the gland.Conclusion: The clinical data analysis used permits to illustrate the underlying pathophysiological mechanisms.

scholarly journals Association of Chronic Kidney Disease with Preserved Ejection Fraction Heart Failure Is Independent of Baseline Cardiac Function

2019 ◽  
Vol 44 (5) ◽  
pp. 1247-1258 ◽  
Author(s):  
Thomas A. Mavrakanas ◽  
Aisha Khattak ◽  
Wei Wang ◽  
Karandeep Singh ◽  
David M. Charytan
Keyword(s):  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Ejection Fraction ◽  
Left Atrial ◽  
Left Ventricular Mass Index ◽  
Secondary Analysis ◽  
Left Ventricular ◽  
Preserved Ejection Fraction ◽  
Left Atrial Diameter

Background/Aims: Chronic kidney disease (CKD) is common among patients with heart failure with preserved ejection fraction (HFpEF) and is associated with worse clinical outcomes. This study aims to identify whether the association of CKD with HFpEF is independent of underlying echocardiographic abnormalities. Materials: We conducted a retrospective cohort study including patients without prevalent heart failure referred for echocardiography. Patients with serial echocardiograms, baseline left ventricular ejection fraction (LVEF) ≥50% and estimated glomerular filtration rate (eGFR) ≥90 mL/min/1.73 m2 were matched 1:1 with patients with eGFR <60 mL/min/1.73 m2 for age (±5 years), sex, history of hypertension or diabetes, use of renin-angiotensin inhibitors, and LVEF (±5%). A secondary analysis included patients with preserved LVEF and normal left ventricular mass index matched for the same parameters except use of renin-angiotensin inhibitors. Results: Patients with CKD were at increased risk for HFpEF admission: crude hazard ratio (HR) 1.79 (95% confidence interval [CI] 1.38–2.32, p < 0.001) and adjusted HR (for coronary disease, loop diuretics, left atrial diameter) 1.64 (95% CI 1.22–2.21, p = 0.001). LVEF and left ventricular diameter decreased over time in both groups but no difference was observed in rate of dropping. Results were similar in the secondary analysis (crude HR 1.99, 95% CI 1.07–3.71, p = 0.03 and HR adjusted for left atrial diameter 1.98, 95% CI 1.05–3.75, p = 0.04). Rate of change was similar for LVEF, pulmonary artery pressure, and left ventricular mass index in both groups. Conclusion: CKD is independently associated with incident HFpEF despite a similar change in relevant echocardiographic parameters in patients with or without CKD.

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