A fatal case of propylthiouracil-induced ANCA-associated vasculitis resulting in rapidly progressive glomerulonephritis, acute hepatic failure, and cerebral angiitis

2015 ◽  
Vol 83 (2015) (05) ◽  
pp. 309-314 ◽  
Author(s):  
Talal Ali Khan ◽  
Francis Cheuk Yin Luk ◽  
Hakim Taalib Uqdah ◽  
Azka Arif ◽  
Humira Hussain ◽  
...  
2013 ◽  
Vol 20 (1) ◽  
pp. 75-79
Author(s):  
Atsushi Mizutani ◽  
Toshiya Kato ◽  
Teiji Nakayama ◽  
Yumiko Honjo ◽  
Fujito Kageyama ◽  
...  

2016 ◽  
Vol 0 (3.74) ◽  
pp. 112
Author(s):  
I.A. Kuchinskaya ◽  
M.V. Bondar ◽  
D.B. Areshnikov ◽  
S.S. Shapoval ◽  
R.D. Dobush

Critical Care ◽  
10.1186/cc560 ◽  
1999 ◽  
Vol 3 (Suppl 1) ◽  
pp. P187
Author(s):  
MC DaSilva ◽  
M Gupta ◽  
MJ Holman ◽  
HG Yang ◽  
RL Conter ◽  
...  

2004 ◽  
Vol 17 (3) ◽  
pp. 163-171 ◽  
Author(s):  
Nils R. Frühauf ◽  
Karl J. Oldhafer ◽  
Stephanie Westermann ◽  
Georgios C. Sotiropoulos ◽  
Gernot M. Kaiser

2021 ◽  
pp. 214-220
Author(s):  
Federica Maritati ◽  
Maria Ilaria Moretti ◽  
Valentina Nastasi ◽  
Roberta Mazzucchelli ◽  
Manrico Morroni ◽  
...  

Many reports have described a high incidence of acute kidney injury (AKI) among patients with COVID-19. Acute tubular necrosis has been reported to be the most common damage in these patients, probably due to hemodynamic instability. However, other complex processes may be involved, related to the cytokine storm and the activation of innate and adaptive immunity. Here, we describe a patient who developed an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis with rapidly progressive glomerulonephritis and lung involvement and an antiphospholipid syndrome soon after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. After viral pneumonia was excluded by bronchoalveolar lavage, the patient has been treated with rituximab for amelioration of kidney function and resolution of thrombosis without any adverse event. We conclude that COVID-19 may trigger autoimmune diseases including ANCA-associated vasculitis. Thus, this diagnosis should be taken in consideration in COVID-19 patients, especially when they develop AKI with active urinary sediment. In addition, considering the relationship between these 2 diseases, SARS-CoV-2 infection should be excluded in all patients with a new diagnosis ANCA-associated vasculitis before starting immunosuppressive therapy.


2000 ◽  
Vol 124 (12) ◽  
pp. 1800-1803 ◽  
Author(s):  
Marius J-M. Ilario ◽  
Jose E. Ruiz ◽  
Constantine A. Axiotis

Abstract Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. We report a case of acute liver failure in a 60-year-old woman following ingestion of phenytoin and trimethoprim-sulfamethoxazole concomitantly over a 9-day period. Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.


2018 ◽  
Vol 33 (1) ◽  
pp. 96
Author(s):  
Joo-Yun Kim ◽  
Hyun-Su Ri ◽  
Ji-Uk Yoon ◽  
Eun-Ji Choi ◽  
Hye-Jin Kim ◽  
...  

1998 ◽  
Vol 33 (7) ◽  
pp. 998-1003 ◽  
Author(s):  
L Nicolette ◽  
D Billmire ◽  
K Faulkenstein ◽  
A Pierson ◽  
C Vinocur ◽  
...  

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