Direct hemoperfusion with a polymyxin B column versus vasopressin for gram negative septic shock: a matched cohort study of the effect on survival

2013 ◽  
Vol 79 (06) ◽  
pp. 463-470 ◽  
Author(s):  
Naoki Sawa ◽  
Yoshibumi Ubara ◽  
Keiichi Sumida ◽  
Rikako Hiramatsu ◽  
Eiko Hasegawa ◽  
...  
Keyword(s):  
Septic Shock ◽  
Cohort Study ◽  
Polymyxin B ◽  
Matched Cohort ◽  
Direct Hemoperfusion ◽  
Gram Negative ◽  
Matched Cohort Study

scholarly journals Potential survival benefit of polymyxin B hemoperfusion in patients with septic shock: a propensity-matched cohort study

Critical Care ◽  
2017 ◽  
Vol 21 (1) ◽  
Author(s):  
Yoshihiko Nakamura ◽  
◽  
Taisuke Kitamura ◽  
Fumiaki Kiyomi ◽  
Mineji Hayakawa ◽  
...  
Keyword(s):  
Septic Shock ◽  
Cohort Study ◽  
Survival Benefit ◽  
Polymyxin B ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Polymyxin B Hemoperfusion

Treatment of Pyonephritis Complicated by Septic Shock Using Extracorporeal Device Polymyxin B-Hemoperfusion

2020 ◽  
Vol 49 (5) ◽  
pp. 627-630
Author(s):  
Gabriele Amoruso ◽  
Nicola Di Venosa ◽  
Luigi Rizzi ◽  
Gianna Lupo ◽  
Armando Gisotti ◽  
...  
Keyword(s):  
Septic Shock ◽  
Treatment Method ◽  
Polymyxin B ◽  
Surviving Sepsis Campaign ◽  
Direct Hemoperfusion ◽  
Gram Negative ◽  
Polymyxin B Hemoperfusion ◽  
Established Treatment

Direct hemoperfusion using polymyxin B-immobilized fiber (PMX-DHP) is an established treatment method for septic shock caused by Gram-negative infections. We report one instance in which PMX-DHP therapy has been used successfully in a 33-year-old woman with septic shock from urosepsis. Although there is lack of recommendations in latest Surviving Sepsis Campaign Guidelines, evidence of PMX-DHP efficacy in this subset of patients is growing.

scholarly journals Intrathecal or intraventricular therapy for post-neurosurgical Gram-negative meningitis: matched cohort study

2016 ◽  
Vol 22 (1) ◽  
pp. 66-70 ◽  
Author(s):  
B. Shofty ◽  
A. Neuberger ◽  
M.E. Naffaa ◽  
T. Binawi ◽  
T. Babitch ◽  
...  
Keyword(s):  
Cohort Study ◽  
Matched Cohort ◽  
Gram Negative ◽  
Matched Cohort Study

scholarly journals Attributable mortality of antibiotic resistance in gram-negative infections in the Netherlands: a parallel matched cohort study

2020 ◽  
Author(s):  
Wouter C. Rottier ◽  
J.W. Timotëus Deelen ◽  
Giorgia Caruana ◽  
Anton G.M. Buiting ◽  
J. Wendelien Dorigo-Zetsma ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Cohort Study ◽  
The Netherlands ◽  
Attributable Mortality ◽  
Matched Cohort ◽  
Gram Negative ◽  
Matched Cohort Study

scholarly journals Albumin Versus Gelatin Solution for the Treatment of Refractory Septic Shock: A Patient Baseline-Matched-Cohort Study

2020 ◽  
Vol 72 (6) ◽  
pp. 451-461
Author(s):  
Surat Tongyoo ◽  
Chawanee Chayakul ◽  
Siwanat Kanoknatsiwattana ◽  
Chairat Permpikul
Keyword(s):  
Septic Shock ◽  
Cohort Study ◽  
Gelatin Solution ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Arterial Blood ◽  
Resuscitation Fluid ◽  
Crystalloid Solutions ◽  
Lower Fluid ◽  
Lactate Levels

Objective: Although albumin solution is the colloid of choice to resuscitate septic shock patients who do not respond to crystalloid solutions, its usage is limited by its cost. Gelatin solution, is less expensive, but its efficacy has not yet been identified. This study aimed to compare the outcomes of gelatin and albumin solutions for septic shock resuscitation.Methods: This baseline-matched-cohort study, enrolled septic shock patients who had a mean arterial blood pressure (MAP) below 65 mmHg after receiving at least 30 mL per kilogram of crystalloid resuscitation fluid, and who required either an albumin or gelatin solution as fluid therapy. The primary outcome was the 28-day mortality.Results: In all, 224 patients who were administered either an albumin or gelatin solution were examined. After adjusting for differences in their baseline characteristics, 206 patients were included (104 receiving albumin, and 102 given gelatin). A comparison of the albumin and gelatin groups revealed no significant baseline differences in their respective mean APACHE II scores (22.8±8.5vs.23.2±8.1), MAPs (55.1±8.0vs.54.6±9.1mmHg), and lactate levels (5.6±4.7vs.6.3±4.9mmol/L). The 28-day mortality rates were 27.9% and 38.2% for the albumin and gelatin groups, respectively, with adjusted p=0.02. Moreover, the accumulation of fluid intake over output at 72 hours was significantly lower for the albumin than the gelatin group (5,964.5±4,959.7 vs. 8,133.2±3,743.2 ml; p=0.01). The RRT rate was higher for the albumin group (30.8% vs. 15.7%; p=0.01).Conclusion: Albumin resuscitation associated with lower 28-day mortality than gelatin resuscitation. The patients in the albumin group had a higher RRT rate and a lower fluid accumulation as at 72 hours.

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