scholarly journals Anti-inflammatory topical medication – new developments in the treatment of atopic dermatitis

2021 ◽  
Vol 5 (01) ◽  
pp. 260-264
Author(s):  
Johannes Wohlrab ◽  
Burkhard Kreft ◽  
Luisa Sophie Scholz
Keyword(s):  
Atopic Dermatitis ◽  
New Developments ◽  
Topical Medication ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory effects of Capparis ecuadorica extract in phthalic-anhydride-induced atopic dermatitis of IL-4/Luc/CNS-1 transgenic mice

2020 ◽  
Vol 58 (1) ◽  
pp. 1263-1276
Author(s):  
Bo Ram Song ◽  
Su Jin Lee ◽  
Ji Eun Kim ◽  
Hyeon Jun Choi ◽  
Su Ji Bae ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Transgenic Mice ◽  
Phthalic Anhydride ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory effect of Amomum xanthioides in a mouse atopic dermatitis model

2017 ◽  
Vol 16 (6) ◽  
pp. 8964-8972 ◽  
Author(s):  
Young-Ae Choi ◽  
Jin Kyeong Choi ◽  
Yong Hyun Jang ◽  
Soyoung Lee ◽  
Sang-Rae Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

New possibilities of external therapy for atopic dermatitis based on the use of natural silicon oxide

2020 ◽  
pp. 44-51
Author(s):  
Sh. Z. Мavlyanova ◽  
A. I. Ismogilov ◽  
J. B. Mullakhanov ◽  
A. U. Burkhanov ◽  
Sh. Khonkhodjaev
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Studies ◽  
Silicon Oxide ◽  
Pathological Process ◽  
Symptom Scale ◽  
New Approaches ◽  
Anti Inflammatory

The article presents new approaches to the external therapy of atopic dermatitis using a moisturizing, toning, anti-inflammatory cream «Fatiderm». Clinical studies have shown that Fatiderm cream helps to reduce the severity of the dermatological index of the symptom scale, eliminate subjective sensations, and improve the dynamics of the skin pathological process.

Anti-inflammatory Effects of Achillea millefolium on Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

2020 ◽  
Vol 48 (05) ◽  
pp. 1121-1140
Author(s):  
Hien T.T. Ngo ◽  
Eunson Hwang ◽  
Hyungoo Kang ◽  
Bom Park ◽  
Seul A. Seo ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Elevated Serum ◽  
Mitogen Activated Protein Kinase ◽  
Raw 264.7 Cells ◽  
Achillea Millefolium ◽  
Raw 264.7 ◽  
Hacat Cells ◽  
Necrosis Factor Alpha ◽  
Cox 2 ◽  
Anti Inflammatory

Achillea millefolium L. (AM) is an aromatic herb with a variety of pharmacological properties, such as anti-inflammatory and anti-allergic activities. However, AM’s effects on atopic dermatitis (AD) have not been investigated. This study evaluates the anti-AD activity of 50% ethanol-extracted AM in murine macrophage Raw 264.7 cells, in tumor necrosis factor-alpha/interferon-gamma (TNF-[Formula: see text]/IFN-[Formula: see text])-stimulated human immortal keratinocyte HaCaT cells in vitro, and in Biostir-AD-treated NC/Nga mice in vivo. The results showed that AM significantly downregulated expression of pro-inflammatory cytokines, such as INOS, COX-2, and interleukin (IL)-6 in lipopolysaccharide (LPS)-treated Raw 264.7 cells. The mRNA expressions of INOS, COX-2, and IL-6 decreased by 76.1%, 69.3%, and 31.8%, respectively. Overexpression of chemokines, such as activation-regulated chemokine and macrophage-derived chemokine, regulated on activation of normal T-cell expressed and secreted, and IL-8 was inhibited by 70.01%, 52.91%, 73.53%, and 18.93%, respectively, in TNF-[Formula: see text]/IFN-[Formula: see text]-stimulated HaCaT cells by downregulating the mitogen-activated protein kinase, I[Formula: see text]B[Formula: see text], and the signal transducer and activator of transcription 1 signaling pathways. AD-like symptoms, such as elevated serum immunoglobin E levels, epidermal thickening, high dermatitis severity score, transepidermal water loss, and reduced skin hydration, were relieved by the dietary administration of AM in Biostir-AD-treated NC/Nga mice. In addition, filaggrin expression increased significantly in AM-treated groups. These results suggest that AM could be a useful candidate for AD treatment.

Supplementary therapy in canine atopic dermatitis

2019 ◽  
Vol 24 (8) ◽  
pp. 400-407
Author(s):  
Sue Paterson
Keyword(s):  
Fatty Acids ◽  
Atopic Dermatitis ◽  
Specific Immunotherapy ◽  
Essential Fatty Acids ◽  
Topical Therapy ◽  
Allergen Specific Immunotherapy ◽  
Canine Atopic Dermatitis ◽  
Adequate Control ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Therapy for canine atopic dermatitis can be described as foundation or supplementary. Foundation therapy, which refers to allergen-specific immunotherapy, ciclosporin, glucocorticoids, lokivetmab and oclacitinib, is needed in all but the mildest of cases of canine atopic dermatitis. Supplementary therapies include drugs such as antihistamines, essential fatty acids, topical therapy and other systemic anti-inflammatory drugs. While it is uncommon for any of these supplementary drugs to provide adequate control of many cases of canine atopic dermatitis, they can reduce the frequency of relapse and reduce the amount of foundation therapy that is required when used in combination with them.

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