scholarly journals COMPARISON OF THERAPEUTIC EFFECTIVENESS OF OXYTOCIN VERSUS OXYTOCIN PLUS TRANEXAMIC ACID IN THE PREVENTION OF POST-PARTUM HEMORRHAGE

2021 ◽  
Keyword(s):  
Tranexamic Acid ◽  
Post Partum ◽  
Therapeutic Effectiveness ◽  
Post Partum Hemorrhage

scholarly journals Prophylactic Tranexamic acid usage in Prevention of Post-Partum Hemorrhage a Prospective Cohort Study

2019 ◽  
Author(s):  
Seifeldin Sadek ◽  
Arnold M Mahesan ◽  
Hadi Ramadan ◽  
Nimra Dad ◽  
Vani Movva ◽  
...  
Keyword(s):  
Cohort Study ◽  
High Risk ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Post Partum ◽  
Secondary Outcome ◽  
Post Partum Hemorrhage ◽  
Estimated Blood Loss

Abstract Background Post-partum hemorrhage (PPH) is the leading cause of obstetric morbidity and mortality around the world. Prophylactic administration of tranexamic acid (TXA) in patients at risk for PPH is aimed at reducing estimated blood loss (EBL). Method This was a prospective cohort study. Patients at high risk of PPH were given 1000mg of TXA intravenously at cord clamping after delivery of the baby, and compared with high PPH risk controls who did not receive TXA. Both cesarean section deliveries (CD) and vaginal deliveries (VD) were included. The primary outcome was postpartum hemorrhage, and the secondary outcome was calculated estimated blood loss (cEBL). Results Between January 2017 and May 2017, 101 patients at high risk for PPH were enrolled. Fifty one received TXA and 50 did not. There were 20 cases of PPH in the TXA group compared with 30 cases in the control group (OR 0.43, 95% CI, NNT=5). The average cEBL for VD and CD were significantly lower in the patients who received TXA compared with controls: 561ml ±336ml compared with 841ml ±462ml (p=0.0006) for VD and 658ml ±294mL compared with 1024ml ±276 for CD (p=0.0007). Conclusions Intravenous TXA may be used as prophylaxis for PPH in obstetric patients at high risk.

Post-partum hemorrhage complicated by reverse-Takotsubo cardiogenic shock; a novel therapeutic approach

2017 ◽  
Vol 35 (6) ◽  
pp. 935.e1-935.e3 ◽  
Author(s):  
John Papanikolaou ◽  
Demosthenes Makris ◽  
Vasiliki Tsolaki ◽  
Konstantinos Spathoulas ◽  
Epaminondas Zakynthinos
Keyword(s):  
Cardiogenic Shock ◽  
Therapeutic Approach ◽  
Post Partum ◽  
Post Partum Hemorrhage ◽  
Novel Therapeutic
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