scholarly journals Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Sahar Mazloomi ◽  
Faranak Sharifi ◽  
Reza Hajihosseini ◽  
Sadroddin Kalantari ◽  
Saideh Mazloomzadeh
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Confounding Factor ◽  
Polycystic Ovary ◽  
Hdl Cholesterol ◽  
Dehydroepiandrosterone Sulfate ◽  
Control Group ◽  
Ovary Syndrome ◽  
25 Oh Vitamin D ◽  
Control Study

Objective. To investigate the possible association of calcium and vitamin D deficiency with hypoadiponectinemia in women with PCOS. Subjects and Methods. In this case-control study, 103 PCOS cases and 103 controls included. The concentrations of calcium, 25-OH-vitamin D (25OHD), adiponectin, insulin, glucose, total cholesterol, HDL-cholesterol, triglyceride (TG), and androgens were measured in fasting blood samples. Results. Adiponectin (8.4±2.7 ng/mL versus 13.6±5 ng/mL in control group, P:0.00), calcium (2±0.1 mmol/L versus 2.55±0.17 mmol/L in controls, P:0.00), and 25-OH-Vit D (30±2.99 nmol/L versus 43.7±5.2 nmol/L in control group, P:0.00) levels were decreased in women with PCOS. Subjects with PCOS had higher concentrations of TG (1.4±0.77 mmol/L versus 1.18±0.75 mmol/L in control group, P:  0.019) and dehydroepiandrosterone sulfate (DHEA-S) (10.7±11 mmol/L versus 9.7±10.4, P:0.02 in control group). There were significant correlations between adiponectin concentrations with calcium (r:0.78, P:0.00) and 25OHD levels (r:0.82, P:0.00). The association of hypoadiponectinemia and PCOS was not significant considering 25OHD as a confounding factor. Conclusion. The present findings indicate that the association of hypoadiponectinemia with PCOS is dependent on vitamin D. A possible beneficiary effect of vitamin D on the metabolic parameters in PCOS may be suggested.

scholarly journals A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study

2008 ◽  
Vol 93 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Olivier Valkenburg ◽  
Regine P. M. Steegers-Theunissen ◽  
Huberdina P. M. Smedts ◽  
Geesje M. Dallinga-Thie ◽  
Bart C. J. M. Fauser ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Atherogenic Lipid Profile ◽  
Control Study ◽  
Atherogenic Lipid

Abstract Context: Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory. Objective: Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters. Design: This was a case-control study. Setting: The study was performed at a single referral center. Subjects: PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls. Main Outcome Parameters: Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula. Results: We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU/liter), TGs (95 vs. 81 mg/dl), cholesterol (196 vs. 178 mg/dl), and LDL-cholesterol (125 vs. 106 mg/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg/dl) and apoA-I (118 vs. 146 mg/dl) compared with controls (all P values ≤ 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS. Conclusions: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.

scholarly journals Association of BsmI variant of vitamin D receptor gene with polycystic ovary syndrome: A case-control study

2020 ◽  
Author(s):  
Nasim Ramezani ◽  
Maryam Ostadsharif ◽  
Hashem Nayeri
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Vitamin D Receptor ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Case Control ◽  
Metabolic Parameters ◽  
Genotypic Frequency ◽  
Ovary Syndrome ◽  
Control Study

Background: Polycystic ovarian syndrome (PCOS) is an endocrine disorder that affects women’s fertility and causes alterations such as obesity, insulin resistance, menstrual irregularities, and polycystic ovaries. The results of the studies show that the issue of vitamin D and vitamin D receptor (VDR) is controversial for PCOS susceptibility. Objective: To investigate the association of BsmI polymorphism in the VDR gene with metabolic parameters in obese PCOS women. Materials and Methods: In this case-control study, 38 obese subjects with PCOS and 40 unrelated obese individuals were evaluated to determine the allelic and genotypic frequency of BsmI variant by Polymerase Chain Reaction Restriction Fragment Length Polymorphism method. Body Mass Index, parathyroid hormone, phosphorus, and calcium were evaluated in all participants. Results: BsmI (rs1544410), (A/G) AA, AG, GG, A, and G percentage of genotypic/allelic frequencies were 65.8, 26.3, 7.9, 78.9, and 21.1 in cases and 57.5, 40, 2.5, 77.5, and 22.5 in controls, respectively. Statistical analysis revealed that the differences in genotypic (p = 0.31)/allelic (p = 0.83) frequencies and dominant (p = 0.45)/recessive (p = 0.35) models between the cases and controls were not significant. This study indicates no association between the BsmI genotypes and metabolic parameters. Conclusion: It can be concluded that VDR BsmI (rs1544410) Intron 8 (A > G) was not associated with obesity along with PCOS susceptibility in the studied groups. Key words: Vitamin D receptor, Polycystic ovary syndrome, Genetic association study.

scholarly journals The influence of infertility on sexual and marital satisfaction in Iranian women with polycystic ovary syndrome: a case-control study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Seyed-Abdolvahab Taghavi ◽  
Shahintaj Aramesh ◽  
Maryam Azizi-Kutenaee ◽  
Helen Allan ◽  
Tahereh Safarzadeh ◽  
...  
Keyword(s):  
Marital Satisfaction ◽  
Polycystic Ovary Syndrome ◽  
Sexual Function ◽  
Sexual Satisfaction ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Case Control ◽  
Control Group ◽  
Ovary Syndrome ◽  
Control Study

Abstract Background The purpose of the present study was to evaluate sexual and marital satisfaction in couples with polycystic ovary syndrome (PCOS). A case-control study was conducted on 90 couples with PCOS and 90 healthy couples as a control group. Three measures were used to evaluate sexual function and marital satisfaction: the female sexual function index (FSFI), the Larson sexual satisfaction, and the ENRICH marital satisfaction measures. Results The results of this study show that the mean scores of sexual function, sexual satisfaction, and marital satisfaction were significantly lower in PCOS couples compared with the control group (P < 0.05). Infertility was reported as the strongest predictive factor for sexual function and marital satisfaction in couples with PCOS (P < 0.05). Compared to the control group, sexual and marital satisfaction was lower in patients with PCOS and their partners. Conclusion Since infertility is the strongest predictive factor for the sexual health of couples with PCOS and sexual health is important in family health and marital life, sexual counseling may prove beneficial for these patients.

scholarly journals Association of vitamin D receptor gene variants with polycystic ovary syndrome: A case control study

2015 ◽  
Vol 13 (12) ◽  
pp. 793-800 ◽  
Author(s):  
Touraj Mahmoudi ◽  
Keivan Majidzadeh ◽  
Hamid Farahani ◽  
Mojgan Mirakhorli ◽  
Reza Dabiri ◽  
...  
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Receptor Gene ◽  
Case Control ◽  
Vitamin D Receptor Gene ◽  
Gene Variants ◽  
Ovary Syndrome ◽  
Control Study

Carotid atherosclerosis in women with polycystic ovary syndrome: Initial results from a case-control study

1996 ◽  
Vol 174 (4) ◽  
pp. 1224-1232 ◽  
Author(s):  
David S. Guzick ◽  
Evelyn O. Talbott ◽  
Kim Sutton-Tyrrell ◽  
Holly C. Herzog ◽  
Lewis H. Kuller ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Carotid Atherosclerosis ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Case Control ◽  
Ovary Syndrome ◽  
Initial Results ◽  
Control Study
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