scholarly journals Unscrambling Egg Allergy: The Diagnostic Value of Specific IgE Concentrations and Skin Prick Tests for Ovomucoid and Egg White in the Management of Children with Hen’s Egg Allergy

ISRN Allergy ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
D. E. Marriage ◽  
M. Erlewyn-Lajeunesse ◽  
D. J. Unsworth ◽  
A. J. Henderson
Keyword(s):  
Specific Ige ◽  
Diagnostic Value ◽  
Egg White ◽  
Optimal Decision ◽  
Egg Allergy ◽  
Characteristic Analysis ◽  
Decision Points ◽  
Specific Ige Antibodies ◽  
Skin Prick Tests ◽  
Antibody Levels

Resolution of egg allergy occurs in the majority of egg allergic children. Positive specific IgE antibodies to ovomucoid (OVM) have been suggested to be of greater predictive value for persistent egg allergy than specific IgE to egg white. The performance of OVM-specific IgE antibody levels in a cohort of children referred for a routine egg challenge was compared with egg white specific IgE levels in predicting a positive egg challenge. 24/47 subjects had persistent egg allergy. Receiver operating characteristic analysis showed that OVM-specific IgE testing was the most useful test for the diagnosis of persistent egg allergy. The optimal decision points for the prediction of persistent egg allergy were >0.35 kUA/L for specific IgE levels to both EW and OVM, and ≥3 mm for SPT. Children with specific IgE levels suggestive of persistent egg allergy need not be subject to an egg provocation challenge, reducing both costs and risks to the child.

scholarly journals Component resolved diagnosis of egg yolk is an indispensable part of egg allergy

2021 ◽  
Vol 49 (2) ◽  
pp. 6-14
Author(s):  
Huang Lunhui ◽  
Shao Yanhong ◽  
Li Shaoshen ◽  
Bao Huijing ◽  
Liu Yunde ◽  
...  
Keyword(s):  
Operating Characteristic ◽  
Egg Yolk ◽  
Specific Ige ◽  
Diagnostic Value ◽  
Egg White ◽  
Enzyme Linked Immunosorbent Assay ◽  
Egg Allergy ◽  
Component Resolved Diagnosis ◽  
Allergen Components

Introduction and objectives: It was urgent to explain the role of egg yolk allergen sensitization to the egg allergic population and we would evaluate the diagnostic value of allergen components in whole eggs, including egg white and egg yolk.Materials and methods: Firstly, we collected 99 positive and 21 negative sera against egg allergy. Then we used modified enzyme linked immunosorbent assay (ELISA) to survey specific IgE (sIgE) to all-proven and single component in eggs, Ovomucoid (Gal d 1), Ovalbumin (Gal d 2), Ovotransferrin (Gal d 3), Lysozyme C (Gal d 4), Serum Albumin (Gal d 5), and YGP42(Gal d 6) in allergic and non-allergic populations. Last but not least, we studied the sIgE reactivities to egg allergen components by receiver operating characteristic (ROC) analysis.Results: Among egg-allergic individuals, nearly 10% were sensitized to five of six egg allergen components, and the cross-reaction frequency between two egg yolk allergens with Gal d 1 was about 30% in the groups diagnosed with egg allergy or non-allergy. The best component-combination diagnosis in egg allergy of Gal d 1+ Gal d 6 demonstrated the largest area under curve (AUC) of 0.994.Conclusions: Our results suggested that there were individual differences in allergenicity of different egg allergen components, especially in the samples negative to egg allergy diagnosed but sensitive to egg yolk components. It was indicated that component resolved diagnosis of egg yolk improved the value for egg allergy management indispensably.

Utility of Gal d 1-Specific IgE Levels in Predicting Reactivity to Boiled Egg in Chinese Children

2021 ◽  
pp. 1-7
Author(s):  
Dan Ming ◽  
Rongxiu Zheng
Keyword(s):  
Specific Ige ◽  
Diagnostic Value ◽  
Egg White ◽  
Chinese Children ◽  
Egg Allergy ◽  
Clinical Sensitivity ◽  
Receiver Operating Characteristic Curves ◽  
Allergen Components ◽  
Quantitative Measurements ◽  
Food Challenges

<b><i>Background:</i></b> Many researchers have reported predicting the outcome of oral food challenges (OFCs) on the basis of specific IgE (sIgE) levels. However, the clinical usefulness of the determination of IgE antibodies to egg allergen components in Chinese children with suspected boiled egg allergy is not well studied. <b><i>Objective:</i></b> Our objective was to assess the diagnostic performance of sIgE to egg white and Gal d 1, 2, 3, and 5 based on the open challenge outcome for boiled egg. <b><i>Methods:</i></b> A total of 48 child patients with a suspect of boiled egg allergy were included. Serum egg white and Gal d 1, 2, 3, and 5 sIgE were measured by ImmunoCAP. Diagnostic value was assessed by area under the receiver operating characteristic curves (AUC). <b><i>Results:</i></b> Using the OFC results as the reference parameter, Gal d 1 sIgE had the highest AUC (0.84) compared with egg white (0.77) and other investigated components (ranging from 0.51 to 0.71). The clinical sensitivity and specificity for the sIgE to Gal d 1 at optimal cutoff (6.15 kU<sub>A</sub>/L) were 73.7% and 96.7%, respectively. Sensitization to Gal d 1 with a cutoff value of &#x3e;7.48 kU<sub>A</sub>/L indicated a 90% probability of positive challenge. <b><i>Conclusion:</i></b> Quantitative measurements of Gal d 1 sIgE antibodies using ImmunoCAP are useful in the management of boiled egg allergy in Chinese children.

Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy

2002 ◽  
Vol 110 (2) ◽  
pp. 304-309 ◽  
Author(s):  
Teresa Boyano-Martínez ◽  
Carmen García-Ara ◽  
José María Díaz-Pena ◽  
Manuel Martín-Esteban
Keyword(s):  
Specific Ige ◽  
Egg White ◽  
Egg Allergy ◽  
Ige Antibodies ◽  
Specific Ige Antibodies

Maternal Avoidance of Eggs, Cow's Milk, and Fish During Lactation: Effect on Allergic Manifestations, Skin-Prick Tests, and Specific IgE Antibodies in Children at Age 4 Years

PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 735-739
Author(s):  
Nele Sigurs ◽  
Gunnar Hattevig ◽  
Bengt Kjellman
Keyword(s):  
Specific Ige ◽  
Normal Diet ◽  
Cow’S Milk ◽  
Positive Skin ◽  
Ige Antibodies ◽  
Cow's Milk ◽  
Number Of Children ◽  
Specific Ige Antibodies ◽  
Skin Prick Tests ◽  
Allergic Manifestations

Two matched groups of children with a family history of atopy/allergy were observed from birth. In one group (n = 65) the mothers had a diet free from eggs, cow's milk, and fish during the first 3 months of lactation, whereas the mothers in the other group (n = 50) had a normal diet. Atopic/allergic manifestations, skin-prick tests, and specific IgE antibodies to egg white and cow's milk during the first 18 months of life have been reported previously. At 4 years of age the children underwent a clinical examination, skin-prick tests, and determination of specific IgE antibodies in serum against certain food and inhalant allergens. Both the cumulative incidence and the current prevalence of atopic dermatitis were significantly lower in the group of children whose mothers had adhered to a hypoallergenic diet during lactation, whereas all other atopic manifestations were similar. The number of children with positive skin-prick tests and specific IgE antibodies did not differ significantly, but the number of positive skin-prick tests and specific IgE antibody reactions in serum was significantly lower in the children of mothers adhering to the diet, indicating a milder degree of sensitization in these children.

Egg white specific IgE levels in serum as clinical reactivity predictors in the course of egg allergy follow-up

2009 ◽  
Vol 21 (4p1) ◽  
pp. 634-639 ◽  
Author(s):  
Elena Montesinos ◽  
Antonio Martorell ◽  
Rubén Félix ◽  
Juan Carlos Cerdá
Keyword(s):  
Specific Ige ◽  
Egg White ◽  
Egg Allergy
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