scholarly journals Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks

ISRN AIDS ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Louis-Jacques van Bogaert
Keyword(s):  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Final Diagnosis ◽  
Hiv Positive ◽  
Low Grade ◽  
Vascular Neoplasm ◽  
Human Herpes Virus 8 ◽  
Sexually Transmitted ◽  
Immunodeficiency Virus ◽  
Hiv Serostatus

Kaposi's sarcoma (KS) is a low-grade vascular neoplasm associated with human herpes virus-8 (HHV-8) infection, and, in the epidemic form, with the human immunodeficiency virus (HIV). Although HHV-8 is present in all body fluids and is sexually transmitted, there are surprisingly few reports of anogenital KS. Clinically, especially in HIV/KS endemic areas, dark stained skin patches or nodules are prone to misdiagnosis, especially in dark-skinned individuals. Therefore, a biopsy is recommended. The histologic appearance spans a broad spectrum of KS and non-KS lesions; therefore, the final diagnosis should be confirmed by HHV-8 immunohistochemistry. We report a series of 36 anogenital biopsies from a group of 16 documented HIV-positive patients; in 20 the HIV serostatus was unknown. There were ten KS (five in HIV-positive patients), and 26 non-KS (11 in HIV-positive subjects) lesions. In the era of HIV/AIDS, anogenital lesions may be the first manifestation of KS in immunocompromised individuals and should be biopsied. The histological diagnosis should be confirmed by HHV-8 immunohistochemistry.

scholarly journals Management of an oncological wound: Diagnosis, conflicting therapies and decision-making

2020 ◽  
Vol 21 (Issue 1 Volume 21, 2020) ◽  
pp. 13-16
Author(s):  
Tommaso Bianchi ◽  
Ambra Di Altobrando ◽  
Yuri Merli ◽  
Federico Tartari ◽  
Barbara Manfredi ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Hiv Positive ◽  
Low Grade ◽  
Vascular Tumour ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Blistering Disease

This article presents the case of a non-HIV-positive patient who contemporaneously suffered from Kaposi’s sarcoma and bullous pemphigoid. Kaposi’s sarcoma is a rare low-grade vascular tumour associated with human herpes virus 8 infection, while bullous pemphigoid is the most common autoimmune subepidermal blistering disease in western countries.

scholarly journals Trends in Kaposi’s Sarcoma in Miami Beach from 1987 to 2007

ISRN Oncology ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-10
Author(s):  
Simon B. Zeichner ◽  
Ana L. Ruiz ◽  
Gabriel P. Suciu ◽  
Rachel Lerner Zeichner ◽  
Estelamari Rodriguez
Keyword(s):  
Kaposi's Sarcoma ◽  
Medical Center ◽  
Kaposi’S Sarcoma ◽  
Vascular Tumor ◽  
Low Grade ◽  
Term Survival ◽  
Distant Disease ◽  
Human Herpes Virus 8

Purpose. Kaposi’s sarcoma (KS) is a rare low-grade vascular tumor associated with the human herpes virus 8. By analyzing the epidemiology, staging, and treatment of KS, we hoped to improve the quality of care at our institution. Methods. Review of the Mount Sinai Medical Center tumor registry database in Miami Beach, FL, USA, identified 143 cases of KS between January 1, 1987 and December 31, 2007. Results. The majority of patients were non-Hispanic whites, non smoking males diagnosed between 1987 and 1996. Most of the patients were HIV positive, with an equal percentage diagnosed with local or distant disease. Most patients received no chemotherapy or radiation. There were no significant differences in patient survival based on sex, HIV status, or radiation received. There was a trend toward improved survival among older patients who smoked, received no chemotherapy, and had localized stage at diagnosis. Multivariate analysis revealed that non-Hispanic whites had a significant worse survival than Hispanic whites (HR = 0.55, 95% CI (0.33, 0.90), ). Patients diagnosed between 1987 and 1996 had a worse survival than those between 1997 and 2007 (HR = 0.33 (95% CI 0.19, 0.55), ). Conclusion. This large retrospective study provides further insight into KS. Ethnicity and date of diagnosis are important predictors of long-term survival.

Acroangiodermatitis mimicking Kaposi’s sarcoma in an HIV-positive man

2018 ◽  
Vol 29 (7) ◽  
pp. 729-731 ◽  
Author(s):  
BP Goorney ◽  
J Newsham ◽  
D Fitzgerald ◽  
L Motta
Keyword(s):  
Human Immunodeficiency Virus ◽  
Causative Agent ◽  
Kaposi's Sarcoma ◽  
Opportunistic Infections ◽  
Human Herpesvirus ◽  
Kaposi’S Sarcoma ◽  
Human Herpesvirus 8 ◽  
Hiv Positive ◽  
Herpesvirus 8 ◽  
Immunodeficiency Virus

Kaposi’s sarcoma (KS) is the commonest human immunodeficiency virus (HIV)-related malignancy with its characteristic cutaneous morphological appearance and histopathological features. However, it can be simulated by other co-morbid opportunistic infections and unrelated dermatological conditions. We describe such a case of acroangiodermatitis in an HIV co-infected man, based on exclusion of KS histologically and the absence of human herpesvirus 8, the causative agent of KS.

scholarly journals Outcomes of patients with Kaposi's sarcoma who start antiretroviral therapy under routine programme conditions in Malawi

2008 ◽  
Vol 38 (1) ◽  
pp. 5-7 ◽  
Author(s):  
Simon D Makombe ◽  
Anthony D Harries ◽  
Joseph Kwong-Leung Yu ◽  
Mindy Hochgesang ◽  
Eustice Mhango ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Treatment Outcomes ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Sub Saharan Africa ◽  
Hiv Positive ◽  
Immunodeficiency Virus ◽  
Unfavourable Prognosis ◽  
Sub Saharan

AIDS-associated Kaposi's sarcoma (KS) is the most common AIDS-related malignancy in sub-Saharan Africa, with a generally unfavourable prognosis. We report on six-month and 12-month cohort treatment outcomes of human immunodeficiency virus (HIV)-positive KS patients and HIV-positive non-KS patients treated with antiretroviral therapy (ART) in public sector facilities in Malawi. Data were collected from standardized antiretroviral (ARV) patient master cards and ARV patient registers. Between July and September 2005, 7905 patients started ART-488 (6%) with a diagnosis of KS and 7417 with a non-KS diagnosis. Between January and March 2005, 4580 patients started ART-326 (7%) with a diagnosis of KS and 4254 with a non-KS diagnosis. At six-months and 12-months, significantly fewer KS patients were alive and significantly more had died or defaulted compared to non-KS patients. HIV-positive KS patients on ART in Malawi have worse outcomes than other patients on ART. Methods designed to improve these outcomes must be found.

scholarly journals Isolated Bulbar Conjunctival Kaposi’s Sarcoma as a Primary Presentation of AIDS: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Sofia Maia ◽  
Miguel Gomes ◽  
Luís Oliveira ◽  
Paulo Torres
Keyword(s):  
Kaposi's Sarcoma ◽  
Human Herpesvirus ◽  
Kaposi’S Sarcoma ◽  
Vascular Tumor ◽  
Hiv Positive ◽  
Unusual Site ◽  
Herpesvirus 8 ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Kaposi’s sarcoma (KS) is a malignant vascular tumor, caused by the human herpesvirus 8. It is one of the commonest tumors in human immunodeficiency virus (HIV) patients and not uncommonly the first manifestation of acquired immunodeficiency syndrome (AIDS).Case. We present a case of an isolated bulbar conjunctival KS on a 43-year-old HIV positive male, with no other lesions. Excision and cryotherapy were performed, and the patient remains free of lesions to date.Conclusion. Isolated bulbar conjunctival KP is an unusual site for its initial presentation and must be kept in mind in HIV positive patients.

MOLECULAR DETECTION OF KAPOSI’S SARCOMA ASSOCIATED VIRUS (HUMAN HERPES VIRUS 8) IN SINO-NASAL CARCINOMA TISSUES

2020 ◽  
Vol 23 (04) ◽  
pp. 286-297
Author(s):  
Hind Hamed Shaker ◽  
Luma Amer Yasir ◽  
Ausama Abed-Alkadum Alajeely ◽  
Saad Hasan Mohammed Ali ◽  
Shakir H. Mohammed Al-Alwany
Keyword(s):  
Kaposi's Sarcoma ◽  
Herpes Virus ◽  
Molecular Detection ◽  
Kaposi’S Sarcoma ◽  
Human Herpes ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Nasal Carcinoma

scholarly journals 687. Iatrogenic Kaposi’s Sarcoma Following Treatment with Vedolizumab

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S397-S397
Author(s):  
Susanne O Ajao ◽  
Hamid Shaaban ◽  
Rajasingam Jayasingam
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Kaposi's Sarcoma ◽  
Symptomatic Relief ◽  
Kaposi’S Sarcoma ◽  
Immunosuppressive Drugs ◽  
Lymph Node Biopsy ◽  
Human Herpes Virus 8 ◽  
Spindle Cells ◽  
Spindle Cell Proliferation

Abstract Background Kaposi’s sarcoma (KS) is a vascular tumor caused by human herpes virus-8 infection (HHV-8) commonly involving the skin. We report a case of a patient with controlled HIV who developed Kaposi’s sarcoma on vedolizumab. Darkened hyperkeratotic plaque on his left medial foot Methods A 39-year-old homosexual male with a history of Ulcerative Colitis (UC), Hodgkin’s lymphoma in remission and HIV presented with complaints of abdominal pain and bloody diarrhea. He had new tender lesions on his left foot which was absent at his previous admission a month ago. The lesions started as macules and later progressed to tender lesions. Mesalamine and oral corticosteroids were previously prescribed without symptomatic relief and he was started on vedolizumab 2 months ago. On physical exam he had abdominal tenderness, tender cervical and inguinal lymph nodes, and dark macules on his feet. Digital rectal exam revealed bloody mucoid stool. Laboratory showed white blood cell count of 12,600/mm3, ESR of 132 mm/hr and CRP of 4.6 mg/dL. His CD4 T-cell count was 873 cells/mm3 and viral load was 50 copies per milliliter. Cervical lymph node biopsy showed polymorphous population of lymphocytes but was negative for malignant cells. Biopsy of the foot plaques showed atypical intradermal vascular and spindle cell proliferation positive for HHV-8 and for vascular marker CD34. The results were consistent with the diagnosis of KS. Serology was also positive for HHV-8 with high viral titers of 74 copies/mL. Colonoscopy showed severe proctitis with deep ulcerations in a continuous pattern in the rectum with a normal sigmoid colon. Follow up colonoscopy showed improved proctitis and he was started on doxorubicin to treat KS with improvement of the foot lesion a month later following treatment. Dark macules on the sole of both feet Figure 3a: Spindle cells with irregular small vessel proliferation and red blood cell extravasation between tumor cells Figure 3b: Immunohistochemical stain showing HHV-8 expression of spindle cells Improvement of the foot lesion Results Vedolizumab is a monoclonal antibody that prevents the recruitment of lymphocytes to the inflamed tissue. It is approved for the treatment of IBD and has shown efficacy and safety. The iatrogenic form of Kaposi’s sarcoma occurs in patients on immunosuppressive therapy, as this patient. Conclusion Patients with IBD on immunosuppressive drugs should be followed up closely and screened for latent viral infections prior to initiating therapy. As in the patient, HHV-8 should be recognized as a likely underlying opportunistic infection in immunocompromised patients with IBD. Disclosures All Authors: No reported disclosures

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