scholarly journals Primary Sclerosing Cholangitis Associated with Elevated Immunoglobulin-G4: A Preliminary Study

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Baran Parhizkar ◽  
Amir Houshang Mohammad Alizadeh ◽  
Hamid Asadzadeh Aghdaee ◽  
Habib Malekpour ◽  
Amir Hossein Entezari

Background. Immunoglobulin IgG4-associated cholangitis (IAC) disease is a systemic disease histologically characterized by extensive T lymphocytes and IgG4 positive plasma cell infiltration in various organs. Prevalence of IAC in PSC patients was reported to be between 7% and 11.6% in a few previous studies. This study was carried out to evaluate frequency of serum IgG4 level in PSC patient referred to the gastroenterology ward of Taleghani educational hospital in Tehran, Iran. Material and Methods. This study was a prospective analytical cross-sectional study. Clinical presentation, laboratory values, imaging changes, inflammatory bowel disease (IBD), esophageal varices, ascites, and child score in newly PSC patients with elevated IgG4 were determined and compared with PSC patients with normal levels of IgG4. Data was analyzed by using SPSS software. The frequency and standard deviations were calculated. Differences among groups were evaluated by using the chi-square, fisher exact, and Mann-Whitney U tests. Results. 34 patients with PSC were examined in the study period, of which 9 cases (26.5%) had high IgG4 levels. Most of the patients were male, 23 cases (67.6%) and nonsmoker, 26 cases (76.5%). Patient average age was 47 years old (range 21–67 years). There was not any significant relationship among patients with IAC and PSC patients in terms of variables such as age, smoking, presence of IBD, ascites, esophageal varices, child score, and imaging findings (). Conclusion. IAC should be suspected in cases of unexplained biliary strictures with increased serum IgG4. Testing PSC patients for IgG4 and treating those who have high levels with corticosteroids in clinical trials should be considered in future studies.

2021 ◽  
Author(s):  
Madiha M Abas ◽  
Shukir Saleem Hasan

Abstract Background and objectives: Colostrum is the first breastfeed which is a product by the mother. it has containing high amounts and concentrations of nutrients and antibodies. Methods: A comparative, cross-sectional study was conducted in different areas in Erbil Governorate. During the period started on 2nd Jan. to the end of May. 2019. Non- probability of 400 mothers who delivered their baby by normal vaginal delivery in the hospitals were recruited. A special tool was constructed by researchers, a direct face-to-face interview was adapted. Data were collected and interpreted to the computer. A special SPSS software version 23 was used for analyzing the data, frequency, chi-square, and two tailed t-test statistical analysis was applied for the study.Results: Incorrect knowledge among Erbil city and Koy-Sanjaq city was observed, with better information among Shaqlawa mothers. Poor practices of colostrum feeding among all mothers, and found a statistically significant association between mother’s knowledge, and relay to an association between mothers’ practices. Statistically significant differences were found between Erbil city and Koy-Sanjaq city; between Shaqlawa city and Koy-Sanjaq city concerning mothers’ practices respectively, with non-statistically differences between Erbil and Shaqlawa mothers, also non-statistically significant differences between mothers’ practices in Erbil and Shaqlawa city. There are statistically differences between mothers in Erbil, Koy-Sanjaq, and between Erbil and Shaqlawa with no statistical difference between Koy-Sanjaq and Shaqlawa mothers regarding knowledge. Conclusions: The mothers in Shaqlawa city had better knowledge and all three districts were having poor practices regarding colostrum feeding.


2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Shereen M. Shokry ◽  
Eman E. El Wakeel ◽  
Nassr Al-Maflehi ◽  
Zaheera RasRas ◽  
Nida Fataftah ◽  
...  

Objectives.The aim of this cross-sectional study was to identify sleeping patterns among dental students and their association with self-reported bruxism in Riyadh Colleges of Dentistry and Pharmacy (RCsDP).Methods.A cross-sectional study was performed including 549 students (67 men and 482 women). A structured questionnaire was adopted from The PSQI (The Pittsburgh Sleep Questionnaire Index) used for data collection. It included questions which are categorized into sleeping habits, sleep-related symptoms, and additional questions concerning bruxism. This questionnaire was randomly distributed among all college preclinical and postclinical students. Sleep bruxism diagnosis was based on self-reported data. The data were analyzed using Chi-square tests through SPSS software for Windows.Results.Statistical analyses revealed significant correlations between self-reported bruxism and sleeping habits including sleep initiation (χ2=22.6,p=0.000), continuous sleep until morning (χ2=19.2,p=0.001), nighttime sleep duration (χ2=20.2,p=0.000), and length of daytime naps (χ2=28.35,p=0.000). There was an association between self-reported bruxism and sleeping-related symptoms including awakening early in the morning before the usual time without a cause (χ2=16.52,p=0.000) and increased nightmares (χ2=13.7,p=0.001).Conclusions.Poor sleeping pattern was an important factor among dental students, who reported sleep bruxism.


Author(s):  
Anna Joseph Lyimo ◽  
Makoye Mang'oma Ndalahwa ◽  
Irene Kida Minja

Aim: This study aimed at determining the prevalence of self-reported and clinically determined dry mouth among elderly patients attending a referral hospital in Dar es Salaam; and to assess factors associated with the condition. Methodology: This cross-sectional study included elderly patients aged 60 years and above who were attending Mwananyamala referral hospital in Dar es Salaam between January and February 2017. Data was collected using structured interview questionnaire, followed by clinical oral examination. Chi-square test was used to check for bivariate associations between variables; and multiple logistic regressions to determine relative contribution of demographic, behavioral and clinical variables on dry mouth. Results: Information was obtained from a total number of 334 elderly patients aged 60-90 years, response rate 86%. The prevalence of self-reported dry mouth (xerostomia) was 65.3% and clinically determined dry mouth 64.1%. Multiple logistic regression analyses revealed that elderly participants who were 70+ years old (OR=2.0, CI=1.1-3.6 and OR=2.5, CI=1.5-4.4); those who used tobacco (OR=2.1; C.I=1.2-3.5 and OR=2.9; CI=1.5-5.6,); those having at least one tooth with cervical caries (OR=1.7, CI=1.0-2.9 and OR=2.9; C.I=1.7-5.1) and poor oral hygiene (OR=2.7; C.I=1.6-4.5 and OR=4.3; C.I=2.5-7.3) were significantly at higher odds for xerostomia and clinically determined dry mouth, respectively. Level of education, systemic disease, and use of systemic medication showed no statistically significantly association with dry mouth i.e xerostomia and clinically determined dry mouth. Conclusions: The results of this study revealed that, the prevalence of complaints of xerostomia and clinically determined dry mouth were high among elderly patients attending Mwananyamala referral hospital. The condition was significantly associated with socio demographic, clinical and behavioral factors showing the need for multi-disciplinary oral health care for this group of population.


2016 ◽  
Vol 5 (2) ◽  
pp. 63-69
Author(s):  
Masoumeh Saeedi ◽  
Mohammad Hossein Khosravi

Background: After otorrhea and hearing loss, Tinnitus is the most common symptom in pa­tients with chronic otitis media (COM). The aim of this study was to evaluate the improvement of tinnitus in COM patients after tympanoplasty and tympanomastoidectomy surgeries. Mate­rials and Methods: This cross-sectional study was conducted on COM patients suffering from Tinnitus referred to Baqiyatallah hospital, Tehran, Iran undergoing tympanoplasty or tympano­mastoidectomy surgeries between March 2013 and August 2014. Tinnitus Handicap Inventory (THI) and Visual Analogue Scale (VAS) questionnaires were filled before and two months after surgery by each patient, and considered subjects were compared with each other. Audiometry test was taken from each patient before and two months after surgery. Audiometry results as well as Air-Bone gap were measured and evaluated prior and after surgery. Data were analyzed using SPSS software by ANOVA, sample t-test and Chi-square tests. Results: Eventually, 26 male and 24 female patients with a mean age of 38.62±11.88 years were enrolled. Air conduc­tion at all frequencies was 49.99±17.37 before and 36.98±22.06 after surgery (P<0.001). Sever­ity of tinnitus was 62.92±30.54 before and 30.54±20.08 after surgery based on THI (P<0.001). Also, it was 7.46±1.66 before and 3.5±2.06 after surgery based on VAS evaluations (P<0.001). Tinnitus severity reduction was significantly associated with the improvement of hearing loss and decrement of air-Bone gap (P<0.001). Tinnitus symptoms such as loudness, annoyance, impact on life and perception of Tinnitus significantly reduced after surgery. Moreover, Tym­panomastoidectomy was more effective on the improvement of Tinnitus in comparison with Tympanoplasty (P=0.019).Conclusion: It seems that, both tympanomastoidectomy and tympa­noplasty surgeries are effective on the improvement of tinnitus in patients with COM; however, Tympanomastoidectom surgery was shown to be more effective.[GMJ.2016;5(2):63-69]


Author(s):  
Ajay Kumar Agarwal ◽  
Ghanshyam Das Katiyar ◽  
Syed Esam Mahmood ◽  
Swati Khan ◽  
Mahendra Sharma

Background: Anaemia is a global health problem. Anaemia is one of most commonly recognized disorders. In view of ever increasing burden of anaemia in India and its detrimental effects on academic performance of students, it is necessary to find out the association of anaemia with BMI of medical and para medical students. This study was undertaken to find out association of anaemia with BMI among medical and para medical students of Rohilkhand Medical College, Bareilly.Methods: This cross sectional study was conducted in 344 medical and para medical students of Rohilkhand Medical College and Hospital, Bareilly. A structured schedule was used to collect the information regarding anaemia and BMI. Data was analyzed using SPSS software. Chi square test was applied.Results: Over all prevalence of anaemia was 29.07% prevalence was higher among female students (41.92%), among those aged between 25-26 years (75.00%) and among Muslims (40.54%), prevalence of anaemia among normal weight (31.92%) followed by underweight (27.02%) than in preobese (25.86%) while least among obese (20.83%).Conclusions: Anaemia is prevalent even in medical and para medical students who are well educated and well oriented about nutrition and its ill effect on health. BMI exhibits higher prevalence of anaemia among normal weight, followed by underweight, preobese and obese. 


2020 ◽  
Vol 11 (SPL4) ◽  
pp. 691-697
Author(s):  
Karthik V ◽  
Sridevi G ◽  
Leslie Rani S

This survey was taken up to analyze the association between food habits and sleep with obesity. The survey involved 200 healthy participants of both genders.  A cross sectional study was planned among the saveetha university students. Generalised questionnaires which assess the food habits of the participants was designed to find how it relates with obesity and PITTSBURGH sleep quality index (PSQI) was used to assess sleep habits of the subject during the past one month. The responses of the questions were tabulated and the correlation of food habits and sleep with the tendency of obesity and gender-related analysis was done using SPSS software version 22 and the statistical test used was chi-square test and the significance value was fixed at p < 0.05. The results revealed that about 49% of people have trouble sleeping. 51% of people less than once a week face trouble. 53 % of people use the bathroom in the middle of sleep. 56% of people drink soft drinks two times per day. There were also significant changes among genders in the intake of junk food intake, appetite and sleep rating. Thus the study concluded that food habits with the intake of junk food and sleep deprivation with gender correlation predispose to obesity.


2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Raidan Ba-Hattab ◽  
Ishrat Rahman ◽  
Lubna K. Elsayed ◽  
Wejdan F. Alasmari ◽  
Randa Abidia ◽  
...  

Aim. During endodontic treatment, dentists may face various unwanted procedural accidents, at any stage of the treatment that might compromise endodontic treatment outcome and bring obstacles to dentists as well. This study aimed to address and analyze several ethical concerns relating to the behavioural conduct of dentists towards endodontic instrument separation as well as perforation of the crown and/or root during root canal treatment in Riyadh, Saudi Arabia. Method. Hundred and eleven questionnaires were distributed among dentists working in Riyadh in university clinics and government and private sectors. Data were collected, reviewed, and statistically analyzed by Fisher’s exact and chi-square tests at a 5% significance level, using SPSS software. Results. 54.5% of the respondents have encountered instrument separation. 53.2% stated that they would inform the patient about the instrument separation. 43.6% of the respondents had experienced perforation during root canal treatment, and 54.9% reported that they would inform the patient of the accident. Conclusion. Within the limitation of this survey, we concluded that most of the dental professionals did not hesitate to adhere to the correct ethical conduct, and they would inform the patient if an incident occurred.


Author(s):  
Maria Sueli Marques SOARES ◽  
Raquel Lopes CAVALCANTI ◽  
Luiz Felipe Fernandes GONÇALVES ◽  
Ionária Oliveira de ASSIS

ABSTRACT Objective: The aim of this study was to evaluate the relationship among the following features: hyposalivation, systemic diseases and drug use, oral symptoms, dental condition, salivary flow and salivary pH, as well. Methods: A cross-sectional study was performed with 50 participants diagnosed with xerostomia, randomly selected and distributed in two groups: 25 with hyposalivation and 25 without hyposalivation, paired in age and sex. Unstimulated Salivary Flow Rate (USFR), Decayed, Missing, Filled, Teeth (DMFT) index and salivary pH were determined. The Mann-Whitney test and chi-square test were applied, considering significant for p-values <0.05. Results: Among the participants with hyposalivation, 88% used drugs and 96% presented systemic disease. And among those without hyposalivation, 48% used drugs and 64% presented systemic disease. The ones with hyposalivation showed the highest levels of dysgeusia (60%) and burn mouth (36%). There were statistically significant differences for the medians of USFR (0.08ml/minute / 0.2ml/minute) (p = 0.000), pH (6/7) (p = 0.000) and DMFT (22/17) (p = 0.004) obtained from participants with hyposalivation and without hyposalivation, respectively. Only in the group with hyposalivation there was a statistically significant association of unstimulated salivary flow rate with age (p = 0.035), type of systemic disease (p = 0.049) and pH (p=0.032) and DMFT demonstrated an association with systemic diseases (p = 0.015). Conclusion: The research results have suggested that hyposalivation worsens dental status triggering oral symptoms, and that salivary flow is influenced by the type of systemic disease and age group.


2021 ◽  
Vol 62 (2) ◽  
Author(s):  
Nguyễn Phương Nam ◽  
Lê Thị Thanh Hương

Objective: The study described the routine hand hygiene of nurses and midwives at Tra Vinh Hospital of Obstetrics, Gynecology and Pediatrics in the year 2020 and some associated factors. Method: This was a cross sectional study. Totally, there were 360 chances of hand hygiene to be observed using a checklist. Data was analyzied by SPSS software version 20.0. Chi square test and odd ratios were applied with significant level at 0.05. Results: The prevalence of routine hand hygiene compliance was 33.3% by chances of hand hygiene, and was 30.3% by nurses and midwives. The highest prevalence of compliance was “After contact with patients” (55.5%) and the lowest prevalence was “After contact with blood and fluids”. Some factors associated with the compliance of routine hand hygiene among nurses and midwives were the availability of hand rubs, facilities supporting hand hygiene compliance, workload, rewards and punishments for the compliance of routine hand hygiene. Conclusion: There is a need to retrain routine hand hygiene for nurses and midwives. Supervision of the compliance of routine hand hygiene needs to be conducted, especially for Departments of Obstetrics, Department of Pediatrics, and Department of Surgical Obstetrics.


2019 ◽  
Vol 92 (1103) ◽  
pp. 20190448 ◽  
Author(s):  
Darya Kurowecki ◽  
Michael N. Patlas ◽  
Ehsan A. Haider ◽  
Abdullah Alabousi

Immunoglobulin G4-related disease (IgG4-RD) is an autoimmune disorder characterized by the infiltration of one or more organs with IgG4-positive plasma cells resulting in inflammatory lesions and fibrosis. Although the pancreas is the most commonly affected organ, involvement of extrapancreatic organs is an increasingly recognized manifestation of the disease. Patients may be asymptomatic and serum IgG4 concentrations may be elevated or normal. Treatment consists of glucocorticosteroid treatment, with excellent response. A definitive diagnosis requires histopathology with imaging playing a key role in avoiding treatment delays. This pictorial review will focus on the most current knowledge regarding IgG4-RD including its common and less common manifestations and the roles of multidetector CT, MRI and ultrasound in the diagnosis and management of suspected IgG4-RD. Knowledge of the varied imaging findings of this multi systemic disease is essential for radiologists to avoid misdiagnosis and assist with timely and effective treatment.


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